Biotin-FA， Biotin Folic Acid

Biotin-FA， Biotin Folic AcidUsually refers toBiotin Folic AcidIt is a compound that covalently links Biotin with Folic Acid (FA). It combines the high affinity properties of biotin with the biological activity of folate, and has wide applications in biomedical research and drug delivery.

Chemical Structure and Composition

• BiotinA water-soluble vitamin (B7) that can form high affinity non covalent complexes with Streptavidin or Avidin, commonly used for molecular labeling, separation, and signal amplification.

• Folic Acid (FA)Vitamin B9 is involved in processes such as DNA synthesis, repair, and methylation. Its targeting originates from the ability to specifically recognize folate receptors (FRs) on the cell surface, especially those highly expressed in tumor cells.

• connection methodBy chemical coupling (such as amidation reaction), biotin is linked to the carboxyl or amino groups of folate to form stable covalent bonds.

characteristic

1. Dual targeting：

• Folic acid end: Through folate receptor mediated endocytosis, tumor cell targeted delivery is achieved.

• Biotin end: binds with streptavidin to further enhance targeting specificity and stability.

2. High affinity and stability：

• The biotin streptavidin complex binds stably and irreversibly, making it suitable for long-term labeling and detection.

• Folic acid is stable in neutral or weakly alkaline environments and maintains binding activity with folate receptors.

3. versatility：

• Conjugated proteins, antibodies, nanoparticles, etc. can be used for multifunctional applications such as fluorescence imaging and drug delivery.

4. biocompatibility：

• Polyethylene glycol (PEG) modification (such as Biotin PEG FA) can improve water solubility and biological inertness, reduce non-specific adsorption, and prolong in vivo circulation time.

Main application areas

1. Targeted drug delivery：

• As a targeted ligand for drug carriers, drugs are encapsulated on the surface of nanoparticles and internalized through folate receptors, increasing drug concentration in tumor tissues, reducing normal tissue distribution, and minimizing side effects.

2. Biomolecular markers and detection：

• Label proteins, DNA, or RNA and achieve high-sensitivity detection and quantification through the streptavidin biotin system.

• Applied to immunofluorescence ELISA、Western Blot、 Immunohistochemistry and other techniques.

3. Molecular imaging technology：

• Combining fluorescent dyes or radioactive isotopes to achieve cell specific labeling and imaging for studying processes such as cell metabolism, migration, and differentiation.

4. Construction of biosensors：

• Modify the surface of the sensor and achieve tumor cell detection by binding folate to folate receptors on the surface of tumor cells.

• The biotin end binds to streptavidin, enhancing the signal intensity and specificity of the sensor.

5. Cell labeling and isolation：

• Cells expressing folate receptors with specific markers are used for cell sorting and purification to improve separation efficiency and purity.

Biotin-FA， Biotin Folic Acid

About Us:

The product categories operated by Shaanxi Xingbei Aike Biotechnology include synthetic phospholipids, polymer polyethylene glycol derivatives, block copolymers, magnetic nanoparticles, nano gold and nano gold rods, near-infrared fluorescent dyes, reactive fluorescent dyes, fluorescent markers, protein crosslinking agents, small molecule PEG derivatives, click chemistry products, dendritic polymers, cyclodextrin derivatives, macrocyclic ligands, fluorescent quantum dots, hyaluronic acid derivatives, graphene or oxidized graphene, carbon nanotubes, fullerenes, silica and mesoporous silica, polymer microspheres, near-infrared fluorescent dyes, polystyrene microspheres, upconversion nano luminescent particles, MRI magnetic resonance imaging products, fluorescent proteins and fluorescent probes, etc.

Kind reminder: The supplied product is only for scientific research and cannot be used for human body!

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