BiomemX uBeat organoid chip

Beijing Kilby Biotechnology Co., Ltd. (hereinafter referred to as "Kilby")Beijing Kilby）ObtainItalian BiomemX SrlapproveTo become its strategic partner in the Chinese region, responsible for the sales promotion and technical services of its full range of products in the Chinese market.

1.BiomemX uBeat organoid chipCore Technology Highlights:Dynamic mechanical force microenvironment BiomimX Srlof uBeat ® The characteristic of the system is that it can simulate the real mechanical environment inside the human body. Traditional organ chips often focus on fluid shear forces or chemical gradients,But BiomemX focuses on stretch and compression stimulation,This is crucial for the functional maturation of many organs.

Simulate physiological movements: It can simulate the rhythmic beating of the heart, the respiratory expansion of the lungs, the peristalsis of the intestines, and the stress load on the knee joints. Promote cell maturation: By applying precise mechanical force, induce stem cells or primary cells to differentiate into tissues that are more functionally mature and closer to their in vivo state (such as synchronizing the beating of cardiac muscle cells).

• UHeart (heart chip): This is one of its flagship products. It can construct a miniature model of the human heart, mature myocardial tissue through mechanical training, and be used to test the effects of drugs on cardiac toxicity (such as arrhythmia) or study cardiac pathological mechanisms.

• Cartilage and Joint Chip: Simulate mechanical loads on knee joints and other parts, used for osteoarthritis research or cartilage material testing.

• Other models include lung (respiratory movement), intestinal (peristalsis), skin, liver, and tumor models.

3. System integration degree： uBeat ® Not just a cultivation device, it is a highly integrated system that includes the following functions:
3D cell culture:Support the construction of three-dimensional microstructures.

Microfluidic technology:Provide nutritional supply and eliminate metabolic waste.
Electrophysiological recordings (uBCG/uECG):Especially for cardiac chips, it integrates electrophysiological recording function, which can monitor the electrical activity of tissues in real time (such as heartbeat rhythm) and achieve synchronous analysis of "structure function",HeartIt can measure key functions of the heart to understand changes in heart rate, electrical activity, contractility, calcium processing, and structural toxicity.HeartBeing able to respond to drugs in a dose-dependent manner, much like the human heart, makes it an ideal platform for screening drug cardiac toxicity.

Micro patterned cultivation:Control the arrangement and growth direction of cells.


4. Industry status and market evaluation:In the field of organ chips, BiomemX is considered to have differentiated competitiveness due to its expertise in "mechanical force stimulation". Most organ chip companies mainly focus on microfluidics, while BiomemX solves the key pain point of "mechanical signal loss". Application scenarios: Mainly used for new drug development (improving the accuracy of drug screening and reducing animal experiments), disease modeling (studying mechanical force related diseases such as heart failure and osteoarthritis), and precision medicine.

Note: BiomemX Srl, a member of the European IAMPS Alliance:Innovation pioneer in the field of microphysiological systems

On February 10, 2026, European companies in the field of microphysiological systems jointly announced the establishment of the Microphysiological Systems Industry Alliance IAMPS（Industry Alliance for Microphysiological Systems）
， BiomemX Srl is from EuropeOrgan Chip Research Alliance IAMPSThe member units. The company is headquartered in Italy and relies on its deep accumulation in the fields of biotechnology, microfluidics, and cell biology to develop in vitro models that can simulate the human physiological environment.

BiomemX's core product uBeat ® It is a dynamic organ chip system based on microfluidic technology. This system can provide a "dynamic" cultivation environment for cellular organs that is close to the real state in the human body by accurately controlling key microenvironmental factors such as fluid shear force and mechanical stress. Especially in drug efficacy evaluation, toxicity prediction, and mechanism research, it can provide more clinically valuable data support for researchers and drug developers.BiomimX uBeat ® Already published in Nature Biomedical Engineering（The influencing factor is 26.6）， Multiple research results have been published in international journals such as Lab on a Chip.

(1) The rhythmic beating of the heart
(2) Respiratory movement of the lungs
(3) Intestinal peristalsis
(4) Mechanical load on knee joint
(5) Various tissue models such as skin, liver, nerves, tumors, etc