3F Powder (fasting/full state simulated gastrointestinal fluid powder)

🔍 Product basic information

Product Name3F Powder (fasting/full state simulated gastrointestinal fluid powder)

Item number: FFF02

Brand: Biorelevant

Specification: 70g powder

Applicable scenarios: In vitro dissolution testing of oral solid preparations (tablets, capsules, granules, etc.), drug absorption mechanism research, bioequivalence pre experiments, etc.

🧪 Detailed introduction: What is FaSSIF/FeSSIF/FeSSGF?

FaSSIF, FeSSIF, and FaSSGF are classic "physiological state simulation fluids" in biopharmaceuticals, corresponding to the physiological environment of different stages of human digestion:

-FaSSGF (Fasting State Simulated Gastric Juice): simulates the acidic environment (pH 1.5-3.0) in the stomach on an empty stomach, contains proteases, and is used to evaluate the initial stage of drug disintegration and dissolution in the stomach.

-FaSSIF (fasting simulated intestinal fluid): simulates the weak alkaline environment (pH 6.5) of the small intestine on an empty stomach, containing bile salts and other components, reflecting the process of drug dissolution and absorption in the small intestine.

-FeSSIF (Eating State Simulated Intestinal Fluid): simulates the postprandial small intestine environment (pH 5.0-7.5), with higher bile salt concentration, closer to the physiological state of "accelerated drug absorption after eating".

The 3F powder kit from Biorelevance integrates the three into independently packaged powders. When used, only water needs to be added in proportion to quickly obtain a simulated liquid that meets international standards (such as USP, EP), avoiding the problems of traditional liquid reagents being prone to spoilage and inconvenient transportation.

✨ Core advantage: Why choose Biorelevant 3F Powder (fasting/full state simulated gastrointestinal fluid powder)?

one ️⃣ Formula science, highly reducing physiological state: The ion concentration, surfactant ratio (such as bile salts), and pH value of the three simulated solutions are optimized based on real human physiological data, and have been validated by multiple SCI literature (such as the International Journal of Pharmaceuticals). The experimental results are more reliable in terms of in vivo correlation (IVIVC).

two ️⃣ Easy to operate and save time and cost: The powder form is stable and can be stored for 2 years at room temperature (only 1-3 months for liquid simulation solution). It only takes 5 minutes to dissolve (add water and stir according to the instructions), greatly reducing the preparation time before the experiment.

three ️⃣ Strong compatibility and adaptability to various experimental needs: Whether it is a regular dissolution apparatus, bioreactor, or cell model, the simulated solution of 3F powder after reconstitution can be directly used, supporting diverse scenarios from basic dissolution testing to complex absorption mechanism research.

four ️⃣ 70g large capacity, high cost-effectiveness: a single box can meet about 50 routine experiments (with a dosage of about 1.4g per time), which is more cost-effective than small packaging and suitable for long-term laboratory use.

❓ Purchase FAQ Q&A

Q1: What is the difference between this powder simulation liquid and commercially available liquid simulation liquid?

A: Liquid simulation liquid needs to be stored in refrigeration (2-8 ℃), which is prone to contamination or component degradation (especially bile salt precipitation) after opening. On the other hand, 3F powder has high stability and can be stored at room temperature. After reconstitution, its performance is consistent with the original liquid, making it more suitable for long-term experimental needs.

Q2: What should be noted when dissolving again?

A: It is recommended to use deionized water or ultrapure water, with a water temperature of ≤ 37 ℃ (simulating body temperature), and operate according to the instructions (such as FaSSGF: 1 bag of powder+250ml water) to avoid severe shaking that may cause bubbles (which may affect the accuracy of dissolution testing).

Q3: Can it be used in the development of other types of drugs? For example, biologics or poorly soluble drugs?

A: Okay! 3F simulation solution is particularly suitable for the development of poorly soluble oral drugs (such as BCS class II/IV). By simulating the solubility of drugs in different physiological environments, it helps evaluate the dissolution bottleneck of drugs in vivo and optimize formulation prescriptions (such as adding surfactants).

Q4: Do I need to avoid light when saving?

A: The powder should be sealed and stored in a dry and cool place (recommended below 25 ℃), avoiding direct sunlight or high temperatures (>40 ℃ may cause component decomposition). It is recommended to use it within 6 months after opening.

Q5: Do you provide technical support?

A: Biorelevance provides detailed product manuals (including reconstitution videos and application cases). After purchase, customers can contact customer service for experimental design guidance. Some university/pharmaceutical clients can apply for free sample testing.

For more product information, please contact our regional agent in China: Shanghai Qifa Experimental Reagent Co., Ltd

If you are interested in any product or other brand, you can do so throughOnline messageLeave your requirements for the functionality

(Note: The content of this article is based on brand public information and industry standard information, and the specific information is subject to the brand information document.)

⚡ Biorelevant hot selling products