371 Incubator - Thermo Fisher Scientific 371/371GPCN Price

371 Incubator - Thermo Fisher Scientific 371/371GPCN Price

In stem cell research, tumor drug screening, and biopharmaceutical processes, the stability and cleanliness of the culture environment are fundamental factors that determine the reproducibility of cell states and experimental results. 371 incubator as Thermo Scientific ™ Steri-Cycle ™ The core products of the series adopt a dual pollution prevention and control system of 140 ℃ high-temperature dry heat sterilization and HEPA high-efficiency filtration, providing protection from air purification to surface sterility for stem cells, primary cells, and various sensitive cell lines. Its 184.1 liter direct heating chamber design maintains temperature uniformity with a temperature control accuracy of ± 0.1 ℃, while supporting 0-20% CO ₂ concentration adjustment, flexibly adapting to diverse application needs from conventional cell passaging to mesenchymal stem cell expansion.

Choosing the 371 incubator means equipping your cell culture work with a standardized hardware system that integrates precise temperature control, efficient sterilization, and continuous cleanliness.

1、 Upgraded pollution prevention and control system: dual insurance of HEPA filtration and high-temperature sterilization

Microbial contamination is the most common and challenging issue in conventional cell culture. The 371 incubator is equipped with independently third-party validated purification capabilities, which establish a complete pollution prevention and control loop from daily operation to regular active sterilization.

One of them is the HEPA continuous filtration system. Under normal operating conditions, the filtration system can continuously purify the air inside the chamber and perform a complete circulation filtration of the air inside the chamber every minute. After closing the door, it only takes 5 minutes for the air quality inside the chamber to return to Class 100 cleanliness standard (international standard ISO5 level), providing sensitive cells with a controlled and clean gas environment at all times.

The second option is an optional 140 ℃ high-temperature dry heat sterilization program. This sterilization mode supports users to sterilize the entire cavity according to experimental needs. The high-temperature disinfection stage should not exceed 3 hours, and the complete sterilization cycle can be controlled within 12 hours, and it can automatically run at night. This sterilization program can effectively kill fungi, molds, yeasts, bacteria, and even spores with strong tolerance, fundamentally eliminating hygiene blind spots that are difficult to reach with conventional chemical disinfection. During the sterilization process, all microbial contaminants, whether airborne or surface attached, can be standardized and removed.

2、 Six sided direct heating: creating temperature uniformity

The heating elements of the 371 incubator are distributed in six directions on the outer wall of the incubator, forming a surrounding heating pattern, which can provide more temperature uniformity compared to the single point heating method. Under the critical 37 ℃ cultivation conditions, the temperature uniformity can be controlled within ± 0.3 ℃, and the temperature control accuracy can reach ± 0.1 ℃.

This temperature control performance is particularly critical for cell types that are highly sensitive to temperature fluctuations. Taking the long-term expansion of mesenchymal stem cells (MSCs) as an example, even during 6-8 weeks of continuous culture, the 371 incubator can still maintain a stable temperature of 37 ℃, effectively avoiding cell stress or differentiation tendency caused by local temperature differences.

The 371 incubator also has fast parameter recovery characteristics. After the user opens the door for sampling or adding liquid, the system can quickly stabilize the temperature and CO ₂ concentration. In terms of the recovery speed of carbon dioxide concentration, the CO ₂ concentration can be restored to the set value of 5 ± 0.2% within 3 minutes after opening the door, which is particularly important for handling cell lines such as HEK293 that are sensitive to the environment and require high adhesion.

3、 Accurate control of CO ₂ concentration and sensor options

The 371 incubator offers two CO ₂ sensor configurations: TC (thermal conductivity) and IR (infrared). TC sensors have a long service life, can withstand high temperature sterilization procedures at 140 ℃, and do not require disassembly; IR sensors have the characteristic of resisting humidity interference and can maintain stable measurement accuracy even in long-term cultivation with frequent humidity fluctuations. Users can choose the appropriate sensor version based on their laboratory usage habits and the sensitivity of cell types.

The carbon dioxide control range of 371 incubator is 0-20%, and the control accuracy is better than ± 0.1%. The equipment is also equipped with CO ₂ tracking alarm function, which provides timely sound and light reminders when the concentration deviates from the set range, helping operators to detect and troubleshoot problems such as gas supply or sensor abnormalities in the first time.

4、 Intelligent control, convenient cleaning, and core parameters

The 371 incubator is equipped with a classic control and monitoring system, which can accurately control all key parameters such as temperature and CO ₂ concentration without the need for complex programming processes. The system also has self diagnostic function, which helps with daily maintenance and troubleshooting, and improves the efficiency of instrument operation.

In terms of cleaning and maintenance, the 371 incubator uses 304 polished stainless steel inner layer material, combined with a 100% concave rounded structure design, eliminating the cleaning dead corners that may exist in traditional incubators. The inner door gasket is made of detachable thin blade silicone material, which can be disassembled, cleaned, and sterilized at high temperatures to effectively prevent dirt residue. Both the air inlet and outlet are equipped with microbial filters, which reduce the microbial content in the air from the inlet end.

summary

The 371 incubator has demonstrated high applicability in stem cell research and conventional cell culture work due to its six sided direct heating design temperature control performance, dual pollution prevention and control mechanism of HEPA continuous filtration and 140 ℃ high-temperature sterilization, and moderate capacity configuration of 184.1 liters. Whether it is iPS cells that require dry maintenance for several weeks or HEK293 cells that require high adhesion and are sensitive to the environment, this incubator can provide stable and clean in vitro growth conditions, providing continuous hardware support for reliable replication of cell experiments.

371 Incubator - Thermo Fisher Scientific 371/371GPCN PriceHangzhou Qiannuo Biological Warehouse offers nationwide direct delivery of spot goods.