2004 micro osmotic pump (200 microliters, slow-release for 4 weeks)

🔍 [Product Basic Information]

Item number: 0000298

Product Name2004 micro osmotic pump (200 microliters, slow-release for 4 weeks)

Core parameters:

-Storage capacity: 200 μ l (with precise scale markings)

-Continuous infusion duration: 4 weeks (± 2 days, stored at room temperature)

-Size: Approximately 1.5cm in diameter and 3.2cm in length (suitable for subcutaneous/intraperitoneal implantation in experimental animals such as rats and mice)

-Material: Medical grade silicone (high biocompatibility, no cytotoxicity)

-Working principle: driven by osmotic pressure (semi permeable membrane controls drug release rate)

Applicable scenarios: pharmacokinetic research, chronic disease model construction (such as diabetes, neurodegenerative diseases), drug release effect verification, etc.

📝 【 Detailed Introduction 】

ALZET 2004 Micro Permeable Pump (item number 0000298) is an implantable continuous drug delivery device designed specifically for experimental animals, with the core advantage of "long-term stability and precise controlled release". Its working principle is similar to that of a "micro osmotic pressure pump": the semi permeable membrane inside the pump body allows water to slowly infiltrate, forming internal pressure, and pushing the drugs in the storage bag to be released uniformly through the release hole, without being affected by animal activities or external environment.

Operation process (taking rats as an example):

1. Filling medication: Inject medication solution through the top opening of the pump body using a syringe (pre experiment is required to confirm the compatibility between the medication and silicone gel);

2. Implantation into animals: Make a small incision along the subcutaneous or abdominal cavity of the animal's back to embed the pump body (operation time<5 minutes);

3. Postoperative observation: The animal can move normally without additional care (the pump weighs only about 2g and has no weight-bearing effect on rats);

4. Removal and recycling: After 4 weeks, remove the pump body through the original incision (reusable or treated as medical waste).

Compatible drugs: Water soluble small molecule drugs (such as peptides, proteins, antibiotics, hormones, etc.) are not suitable for high viscosity or granular drugs (which may block the release hole).

🎯

1. 4-week long-term controlled release, say goodbye to frequent tonics: Traditional gastric lavage or injection requires daily/alternate day operation, ALZET 2004 can be maintained for 4 weeks with one implantation, greatly reducing animal stress and laboratory workload.

2. Accurate rate and reliable data: The release rate is determined by the physical parameters of the pump body (semi permeable membrane area, drug concentration), with an error of less than ± 5%, avoiding human error in manual administration.

3. Minimally invasive implantation, animal welfare friendly: the incision is only 1-2mm, the postoperative recovery is fast, it does not affect the animal's eating and activity, and meets the ethical requirements of experimental animals.

4. High biocompatibility: Medical grade silicone material has no immune rejection reaction, and long-term implantation will not cause inflammation or fibrosis (certified by ISO 10993 biosafety).

5. Transparent and visible, with visible status: The pump body is designed to be semi transparent, allowing the remaining amount of medication in the storage bag to be observed with the naked eye, avoiding undetected drug depletion.

❓ 【 Purchase Questions&Answers 】

Q1: What should be noted when filling medication?

A: Need to use a syringe and a drug solution with a pH of 5-8 (strong acid/alkaline may corrode silica gel); The recommended filling amount is ≤ 180 μ l (leaving 20 μ l of space to prevent excessive pressure).

Q2: Can it be used for mice? Is there a requirement for weight adaptation?

A: Okay! Both mice (≥ 20g) and rats (≥ 150g) are suitable. If used for smaller animals (such as young mice), it is recommended to choose the ALZET mini model (such as the 1002 model).

Q3: How to locate the pump body after implantation? Will it affect animal imaging?

A: The pump body is made of X-ray opaque material, which can be clearly located during CT/MRI scanning; It is recommended to avoid the main organs (such as subcutaneous tissue on the back of rats) for implantation, as it does not affect routine testing such as ultrasound.

Q4: Will the drug release rate change over time?

A: In theory, the release rate should remain stable within 4 weeks (± 2% affected by temperature). If the ambient temperature is greater than 37 ℃ (such as in the heating model), the release rate will slightly accelerate (requiring pre experimental calibration).

Q5: Do we need sterile packaging? How to handle it after removal?

A: The factory packaging is for independent sterilization (EO sterilization), and it needs to be filled and used within 24 hours after opening; After removing the pump body, it should be treated as medical waste and cannot be sterilized again for reuse.

Can multiple pump bodies be implanted simultaneously?

A: Okay! Each rat can implant up to 2 pieces (total weight ≤ 4g), with a spacing of at least 1cm to avoid mutual compression.

Q7: How to confirm drug compatibility?

A: Suggest conducting a small-scale test first (such as contacting the drug with silicone gel for 24 hours) to observe whether there is swelling or precipitation; ALZET provides a Drug Compatibility List for reference.

Q8: How long is the validity period? Can it still be used after expiration?

A: Shelf life of 2 years in unopened state (see packaging code); Silicone may age after expiration and is not recommended for use.

Q9: Does it support customized capacity or duration?

A: ALZET offers multiple specifications (such as 100ul/2 weeks, 500ul/6 weeks, etc.). If customization is required, please contact our agent Shanghai Qifa.

For more product information, please contact our regional agent in China: Shanghai Qifa Experimental Reagent Co., Ltd

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(Note: The content of this article is based on brand public information and industry standard information, and the specific information is subject to the brand information document.)

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