- Phone
-
Address
Building A, 27th Floor, Huadu Building, 838 Zhangyang Road, Pudong New Area, Shanghai
Product Categories
Avito (Shanghai) Pharmaceutical Technology Co., Ltd
Potassium sucrose octasulfate
NegotiableUpdate on 05/06
- Model
- Nature of the Manufacturer
- Producers
- Product Category
- Place of Origin
Overview
Product Name: Potassium Sucrose Octasulfate 011001 $r $n English Name: Potassium Sucrose Octasulfate $r $nCAS No. 73264-44-5 $r $n Molecular Formula: C12H14K8O35S8 $r $n Molecular Weight: 1287.52 $r $n Appearance: White Solid Powder $r $n Purity: 99.8% r $n Content: 100.7% r $n Solubility: ≥ 100mg/mL (H2O) $r $n Melting Point gt;230℃
Product Details
Product namePotassium sucrose octasulfateO11001
English name: Potassium Sucrose Octasulfate
CAS number 73264-44-5
Molecular formula C12H14K8O35S8
Molecular weight 1287.52
Appearance: White solid powder
Purity 99.8%
Content 100.7%
溶解性≥100 mg/mL (H2O)
Melting point>230 ℃
During the drug development process, many different formulations of anionic drug encapsulating solutions were screened. Research has found that sucrose octasulfate is a good anionic drug embedding solution. Sucrose octasulfate is added to the finished product production process and reacts to produce triethylammonium sucrose octasulfate (TEA-SOS). Compared with other formulations, this formulation maintains encapsulation efficiency and has a higher retention rate of irinotecan in liposomes.
Potassium sucrose octasulfate(K-SOS) [CDE registration number: F20210000349; AVT item number: 011001, pharmaceutical injection grade, GMP production, bulk stock supply] is a new type of excipient used as raw material to prepare triethylammonium sucrose octasulfate (TEA-SOS) for liposome drug delivery. Sucrose octasulfate is converted to TEA-SOS through ion exchange. TEA-SOS and lipids are passively encapsulated by polycarbonate membrane compression to form liposomes. Subsequently, TEA-SOS outside the liposomes was removed by filtration, forming an electrochemical gradient across the lipid membrane of the liposomes.
