Photoresist is a complex mixture composed mainly of organic solvents, polymer resins, photoacid agents (PAG), and additives. Among them, photoacid is a key component of photoresist, which plays a decisive role in the sensitivity and resolution of photoresist. The purity and impurity control of photoacid agents have a significant impact on the yield of photoresist and the entire semiconductor product. The common composition of photoacid agents is the cationic part of triphenylsulfide and the anionic part of polyfluorosulfonate. The anionic part has almost no UV absorption, and the electrospray detector (CAD) does not rely on compounds to have optical activity, making it an ideal detector for controlling the quality of photoacid agents.

The photoacid generator (PAG) in photoresist is a key component that releases acid after UV exposure, driving the chemical reaction of the photoresist. The electric mist detector (CAD) of Yingmai Instrument is capable of detecting photoacid agents, especially in monitoring PAG concentration and stability, which is crucial for ensuring semiconductor processes.

2 '- fucosyllactose (2' - FL) is an abundant oligosaccharide in breast milk, belonging to the human milk oligosaccharides (HMOs). It has multiple physiological functions, including promoting the growth of probiotics, inhibiting harmful bacteria, and regulating immunity. It has been approved as "safe" (GRAS) by the US FDA and added as a food ingredient to infant formula.

20- (tert Butoxy) -20-oxoicosanoic acid is a long-chain alkyl diacid derivative with acidity that can be synthesized through esterification reactions. It is mainly used as an intermediate in organic synthesis. This compound is of great significance in the field of drug synthesis, especially in the synthesis of bioactive molecules, such as insulin derivatives, which are used to prepare bioactive molecules for the treatment of diabetes, obesity and other diseases.

According to the 2020 edition of the Chinese Pharmacopoeia, substances related to ursodeoxycholic acid were detected using thin-layer chromatography, and the content was determined using titration. This article developed an electrospray detection method to improve the applicability and repeatability of the original method, as well as to increase the detection limit of impurities and enhance the quality control level of the drug.

Tobramycin, also known as tobramycin, is an aminoglycoside antibiotic. Aminoglycoside antibiotics do not contain conjugated structures and have weak UV absorption, making them unsuitable for direct analysis using conventional UV detectors. The detection of related substances in tobramycin raw materials in the 2020 edition of the Chinese Pharmacopoeia uses an evaporative light scattering detector (ELSD), which has lower sensitivity and poor repeatability compared to CAD; The microbiological assay method is used for content detection, but the method specificity is poor. Use HPLC-CAD method to detect the related substances and content of tobramycin.

Non derivatization and direct detection of 17 amino acids by electrospray detector (CAD) combined with high performance liquid chromatography (HPLC) showed significant technical advantages. Compared to traditional methods, this technology eliminates the tedious derivatization steps, avoiding sensitivity fluctuations and quantitative deviations caused by unstable derivatization reagents, side reactions, or product diversity.

This article uses a electrospray detector (CAD) to investigate the detection method of D-ribose, which has high sensitivity, good repeatability, and good linearity. It provides a new high-sensitivity detection method for D-ribose detection and a new idea for better quality control of D-ribose.