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NanoDeBEE homogenizer: a precision equipment designed specifically for nanoscale dispersion systems
Date: 2025-11-21Read: 0
Obtaining nano dispersion systems with uniform particle size and excellent stability is the key to technological success in the fields of nanomedicine, cosmetics, food, and advanced materials.NanoDeBEE homogenizerDeveloped by American BEE International, it is specially designed for handling complex systems such as nano lotion, liposome, nano crystal and polymer micelle, and is known as the "gold standard of nano dispersion".
The core advantage of NanoDeBEE lies in its unique Interaction Chamber ™) Technology. This technology achieves efficient and gentle energy transfer by precisely controlling the high-speed collision, shear, and cavitation of fluids within microchannels. Compared to traditional valve homogenizers, it has higher energy utilization efficiency and lower thermal effects, making it particularly suitable for the treatment of thermosensitive biomolecules such as proteins and mRNA.
The device provides a wide range of pressure regulation (up to 45000 psi) and supports single or multiple cycle modes. Its modular design allows for quick replacement of different specifications of chambers, adapting to different needs from research and development (mL level) to pilot testing (L level). Meanwhile, the integrated temperature sensor and cooling jacket can maintain the sample between 4-25 ° C, ensuring the stability of the active ingredient.
In practical applications, NanoDeBEE has been widely used to prepare siRNA lipid nanoparticles (LNP), paclitaxel nanocrystals, vitamin E nanoemulsions, and other products. For example, a mRNA vaccine project using NanoDeBEE can obtain LNP with an average particle size of 80 nm and PDI<0.1 in one pass at 25000 psi, with an encapsulation efficiency of over 95%.
In addition, the equipment complies with cGMP and 21 CFR Part 11 requirements, supports automatic data collection and remote monitoring, and facilitates process amplification and technology transfer. Its compact body and low-noise design also make it suitable for GLP laboratory environments.
In summary, the NanoDeBEE homogenizer has become a key tool for the research and industrialization of nanodispersion technology due to its precision engineering, good performance, and compliance.
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