In the application of new energy-saving evaporation equipment in the pharmaceutical industry, cylindrical filter machines are usually combined with energy-saving evaporation technologies such as thin film evaporators or falling film evaporators to form efficient and continuous concentration and purification systems.
1、 Application scenarios of cylindrical filter machine:
1. Concentration of drug extract
Suitable for preliminary concentration of traditional Chinese medicine extracts and chemical drug synthesis solutions, removing solvents and retaining active ingredients.
2. Refinement of raw materials
Perform solid-liquid separation on the solution before crystallization or drying to remove impurities such as proteins, polysaccharides, and insoluble particles.
3. Sterilization and filtration of injections or oral liquids
Cooperate with microfiltration or ultrafiltration membranes to remove microorganisms, particles, and impurities, meeting the sterile requirements of drugs.
4. Solvent recovery
Recovering high-value solvents after synthesis reactions reduces production costs and environmental pressures.
2、 Technical features and advantages:
1. Core technology of cylindrical filter machine
Structural design:
Adopting a vertical or horizontal cylindrical filter layout to increase the filtration area, it is suitable for high viscosity or liquid containing solid particles.
The filter material is mostly stainless steel or polymer material, which meets GMP requirements.
Efficient solid-liquid separation:
Rapid filtration is achieved through centrifugal force or pressure difference, reducing clogging of the filter cake layer and extending the lifespan of the filter element.
Can be backwashed online (CIP/SIP) to reduce maintenance costs.
2. Integration of energy-saving evaporation equipment
Thin film evaporation technology:
The liquid medicine forms a thin liquid film on the heating wall, which has a short heating time and avoids the degradation of thermosensitive components.
Vacuum operation reduces boiling point and energy consumption.
Falling film evaporation technology:
The material liquid is evenly distributed from the top and flows down along the pipe wall in a film shape, suitable for high concentration or easily scaling material liquids.
Secondary steam can be recovered for preheating the feed and improving thermal efficiency.
3. Advantages of Joint Systems
Process continuity:
The cylindrical filter is connected in series with the evaporator to achieve integrated operation of "filtration concentration purification", reducing intermediate links.
Energy conservation and environmental protection:
Vacuum evaporation reduces heating temperature and energy consumption; The solvent recovery rate can reach over 95%.
Reduce wastewater discharge and comply with green pharmaceutical requirements.
Product quality improvement:
Low temperature operation preserves the active ingredients of the drug;
High precision filtration ensures sterility and particle control.
