XposeALI 3D In Vitro Cell Exposure Module

XposeALI 3D In Vitro Cell Exposure ModelblockMake PreciseInhale gasSol generatorCombined with 3D cell models cultured in gas-liquid interface (ALI), the cellular effects caused by particles in the air can be studied.

This module needs to be used in conjunction with the PreciseInhale aerosol generator, as shown in the figure below. Each module and host are produced by Inhalation Sciences Sweden AB (ISAB), an innovative instrument listed company headquartered in Sweden that provides analytical instruments and research services. Its products are mainly used for aerosol and inhalation formulation research.

By PreciseInhaleqiSol generatorGenerate inhalable particle size aerosols and expose them to cells through XposeALI. XposeALI ensures that aerosols do not come into contact with cell culture media or contaminate the walls of the transwell chamber. Cells come into contact with the culture medium from below throughout the entire exposure process. After the aerosol exposure is completed, the cells are placed back in the incubator and incubated for an appropriate period of time, and the cell effects induced by aerosol exposure are studied by analyzing the cells or their culture medium.

XposeALI 3D in vitro（In Vitro）Cell exposure moduleThere are the following advantages and features:

• Under simulated lung like conditions, expose the aerosols generated by dry powder, inhaled formulations, or nebulized solutions to cultured cells.

• Ensure uniform deposition of particles in exposed cells, aerosols only deposit on cells and do not deposit on the walls of the insert chamber or culture medium.

• No solvents or excipients need to be added during exposure; Pure API or other materials can be directly delivered to cell cultures.