IEX chromatography column production with 25 years of expertise in monoclonal antibody protein characterization $r $nADC characterization $r $n amino acid characterization $r $n nucleic acid and peptide characterization
Provide ultra-high resolution for the separation of proteins and their variants using Thermo Scientific ProPac WCX-10 LC series chromatography columns. Based on a stationary phase composed of 10 μ m non porous polymer microspheres, the ProPac chromatographic column can separate isomers with only one charged residue difference. The hydrophilic layer of bonding avoids unnecessary secondary interactions. Cation exchange surfaces provide pH based selective control and rapid mass transfer for efficient separation and moderate capacity
Thermo Fisher products are widely coveredSample Preparation Products, SureSTART All Star Sample Bottles, Gas Chromatography Columns and Consumables, Small Molecule Liquid Chromatography Columns, Large Molecule Liquid Chromatography ColumnsandLow flow chromatography column6 major product seriesFully support the workflow of industries such as pharmaceuticals, biopharmaceuticals, food, environment, chemical engineering, and forensic medicine.
✦Batch with better reproducibilityProPac 3R monodisperse, small particle size bioIon exchange column✦Better performanceHypersil GOLD Peptide Peptide Analysis Column✦EquivalentHypersil Chiral chiral column based on polysaccharides✦GLP-1 peptideDrug analysis solutionsIncluding siRNA, gRNA, mRNA, etcNucleic acid analysis solution✦If more is neededAntibody co preparations, multifunctional antibodiesPlease contact Shanghai Jingrui Science for new applications✦increasedLiquid chromatograph selection cardThe application demonstration of newly developed consumables in IgG1, IgG2, IgG4, ADC, and bispecific antibody separation and characterization in recent years, especially the ProPac Elite WCX chromatographic column, MAbPac SEC-1 chromatographic column, CX-1 Buffer linear pH gradient buffer system, and the new Smart Digest enzymatic hydrolysis kit, highlights the application advantages of these four characteristic products; At the same time, some ion exchange, reverse phase, and hydrophobic analysis methods used in fusion protein analysis were demonstrated. With more and more excipients being included in pharmacopoeias, the demand for quality control, process residue, and content determination of excipients has also increased year by year. This article also shares new methods for quality control and content determination of common excipients in protein preparations.The application of reverse phase chromatography columns such as AcclaimC18, AcclaimPA2, Hypersil Gold C18 with fully porous silica gel matrix, Accucore Biphenyl with high-throughput core-shell matrix, Accucore C18, and MAbPac RP with polymer matrix in the analysis of peptides of different sizes and structures highlights the orthogonal selectivity of different matrices and functional groups in separating peptides. At the same time, the retention time differences of peptides with different molecular weights were analyzed using BIOBASIC SEC size exclusion chromatography columns with different exclusion ranges. This article also shares the differences in retention time and separation efficiency of peptide samples on BIOBASIC SCX strong cation exchange columns at different pH values. In the process residue and excipient analysis of peptide preparations, Acclaim OA organic acid specific columns, Hypercarb chromatography columns and other characteristic products are also used to solve the problem of simultaneous analysis of polar and non-polar components.The nucleic acid specific reverse phase column DNAPac RP and ion exchange column DNAPac PA not only excel in the application of n-1 impurities, phosphate ester isomers with different thio modifications, and alternating methylated thio isomers in oligonucleotide drugs, but also have advantages in the tail addition, mRNA sequence determination, mRNA purity determination, and plasmid purity determination of large nucleic acid drugs such as mRNA. The success of nucleic acid drugs cannot be achieved without breakthroughs in delivery technology. This article also uses different analytical methods to detect the composition of nanoliposomes, adenovirus composition, and polyimide content.For the determination of albumin oligomers using the rapid MAbPac SEC-1 chromatographic column in traditional vaccines, the determination of immunoglobulin saves half of the analysis time; The use of MAbPac RP chromatography column for the determination of total protein content in the new vaccine is particularly suitable for the analysis of complex matrix samples due to its alkaline resistance. The use of BIOBASIC SEC chromatography column for total protein determination of animal vaccines has solved the problem of significant deviation in ELISA results. At the same time, the residual organic solvents that need attention in vaccine formulations are also measured using advantageous gas chromatography columns.All products, consumables, and accessories are sourced from Thermo Fisher Scientific's original factory. The company has a professional technical team with a wide coverage, high efficiency, and fast response speed! In addition to selling instruments, accessories, and consumables, we can also provide one-stop product and service solutions such as maintenance, upkeep, and training!
【Shanghai Jingrui Scientific Instrument Co., Ltd thermofisher merk supelcofirst-level agent Legitimate authorization Worry-free after-sales service】A professional providerHPLCChromatographic columnGCChromatographic columnSPEA company that specializes in pre-processing small columns and other commonly used laboratory consumables and accessories,Simultaneously providing various imported standard products and analytical instruments
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