Swedish Biotech Fluidics Liquid Chromatography Detector

SwedenBiotech FluidicsLiquid chromatography detector

Herna SupplySwedenBiotech FluidicsLiquid chromatography detectorDirectly purchased by the German headquarters, near30Years of experience in importing industrial products, original products, supporting selection, providing you with one-on-one solutions: stable delivery time, excellent quotation, affordable price, with a presence in China8The large office provides relevant after-sales services.

1、 Company Profile

Biotech Fluidics ABestablished in2007Year, headquartered in Onsala, Sweden（Onsala）, is a technology enterprise specializing in fluid system solutions, liquid chromatography detectors, degassing equipment, and fluid system components. The company provides chromatography instruments, detectors, and consumables to instrument developers, manufacturers, and distributors around the world, as well as solutions for gas and bubble problems in fluid systems.Biotech FluidicsWe have subsidiaries in the United States and Japan, covering multiple fields such as liquid chromatography, flow path chemistry, fluid distribution, dissolution testing, automated immunoassay, in vitro diagnostics, and semiconductor manufacturing.

2、 Product type

Biotech FluidicsThe main products in liquid chromatography detectors and related fields include:

Differential refraction（RI）HPLCdetector

Miniature fluorescence detector

miniaturepHdetector

Miniature photometer

Online Degasser

Liquid phase flowmeter

Micro flowmeter

Online pressure sensor

Conductivity meter (micro modular)

Solvent recovery device（SPR-200）

3、 Main models

AB-20101——REFRACTiMASTER®Differential refraction（RI）HPLCdetector

RefractoMax™ —— Differential refraction（RI）HPLCDetector series (includingRefractoMax521Waiting for multiple versions)

Runge Mikron 71——Micro modular fluorescence detector

Runge Mikron 91——Micro modularizationpHDetector (including analytical and preparation flow cell specifications)

DEGASi® PLUS——Multi channel online deaerator series

DEGASi® PLUS Nano——Nanofluidic online deaerator (static liquid volume)25 µL）

DEGASi® PLUS ultraNano——Ultra low flow nanofluidic online deaerator (static liquid volume)6 µL）

Biotech Micro Flow Meter——High resolution micro flow sensor (flow range)10 nL/min~80 µL/min）

Biotech Liquid Flow Meter——Liquid phase flowmeter (providing continuous flow monitoring over a wide range of flow rates)

DEGASi® Integration series——Integrated Degassing Machine Series (capable of monitoring vacuum degree and supporting system integration)

4、 Product Introduction

1. REFRACTiMASTER®Differential refraction（RI）HPLCDetector (model:AB-20101）

The detector isBiotech FluidicsFacing the modern eraHPLCThe differential refractive index detector developed by the system adopts the principle of deflection differential refractive index for detection. When the sample flows through the flow cell, the change in refractive index of the liquid causes a change in the deflection angle of the optical path. The photoelectric element measures this deflection angle and converts it into an electrical signal output. It does not rely on the chromophore or ionization properties of sample molecules and can respond to various compounds.

Product Equipment4.3Inch touch screen and user interface, supporting from room temperature to80°CTemperature setting (step size)1°C）. The detector is equipped with an automatic detection function for sample flow path blockage and an overvoltage protection device to prevent damage to the flow cell due to blockage.

Technical Specifications:

Measurement type: deflection type differential refractive index

Refractive index range:±1.75 n

Full range:512 µRIU

Measuring range:500 µRIUThe250 µRIUThe125 µRIUThe62.5 µRIU(switchable)

Noise level:<1.0×10⁻⁹RIU

Drift:<0.001 µRIU/h

Flow pool volume:7.8 µL

Maximum pressure resistance of circulation pool:0.7 MPa

Temperature range: room temperature~80°C(Step size)1°C）

Temperature accuracy:±0.5°C

Temperature stability:>0.01°C

Flow rate range:0.1~10.0 mL/min

Wetting material:316Lstainless steelPTFEThePEEKQuartzPPS

display:4.3Inch colorTFTtouch screen

Power requirements:AC 90–270V，50-60 Hz

power waste:80 VA

Size:420×260×160 mm

Weight:8 kg

Communication interface: Analog output（±1V）Analog input (±)2.5V）TheTTLdigital input/OutputUSBTheLAN

2. Runge Mikron 71Miniature fluorescence detector

Runge Mikron 71It is a miniature modular fluorescence detector with a diameter of32 mm, Length128 mmIt can be equipped with multiple interchangeable fixed wavelength filters, light sources, and flow cells to achieve simulation and emission fluorescence measurement. The detector adopts a long lifespan and low power consumptionLEDLight source, can be as low as4°CUsed in low-temperature environments. The device is equipped with a reference channel, which does not require external calibration and can be accessed through a single channelUSB-CThe port completes power supply and data communication, with driver programs suitable for multiple chromatographic software packages, and can also be customized and integrated using open protocols.

3. Runge Mikron 91miniaturepHdetector

Runge Mikron 91It is an online tool for liquid chromatographypHFlow type miniature for detectionpHDetector, diameter32 mm, Length115 mmIncluding full temperature compensationpHDetection system with long lifespanISFETMeasuring electrodes andKClorAg/AgClReference electrode. The circulation pool adoptsPEEKMaterials provided1.0 mmand2.2 mmTwo inner diameter specifications, pressure resistant20 barCan withstand up to1,000 mL/minThe flow rate and back pressure are lower than1 barThe detector can store calibration data and electrodes in various locationspHThe exposure time within the range is convenient for maintaining predictions. Equipment passes throughUSB-CThe port completes power supply and communication, with driver programs suitable for multiple chromatographic software packages, and can also be customized and integrated using open protocols.

4. Biotech Micro Flow MeterMicro flowmeter

Biotech Micro Flow MeterIt is a high-resolution thermal flow sensor suitable for nanofluidic systems. flow range10 nL/min~80 µL/minThe resolution is1 nL/minThe device is designed non invasively, compatible with most solvents, and equipped with easy-to-use software applications to achieve continuous recording, monitoring, and storage of flow data.

5. DEGASi® PLUSSeries online deaerator

DEGASi® PLUSThe series is a multi-channel online vacuum degassing machine designed to remove dissolved gases from flowing liquids and prevent analysis interruptions caused by bubbles. This series provides1~6Channel configuration, with smaller structural dimensions, equipped with a new generation vacuum pump, and lower noise. among whichDEGASi® PLUS Nano(Static liquid volume)25 µL）AndDEGASi® PLUS ultraNano(Static liquid volume)6 µL）It is a degassing machine developed specifically for nanofluidic systems, using a metal free liquid channel with biocompatibility, based onAF SystemMembrane, suitable for aqueous media and most organic solvents.

5、 Advantages and Characteristics

Biotech FluidicsThe characteristics of liquid chromatography detectors and related fluid products are reflected in the following aspects:

1. Differential refractive index detector has a wide temperature range

REFRACTiMASTER®The working temperature of the detector ranges from room temperature to80°CStep size1°CA higher working temperature helps reduce the back pressure of the chromatography system and can be used in conjunction with a column temperature chamber.

2. Differential refractive index detector with built-in overvoltage protection

The detector is equipped with an overvoltage protection device. When the flow path overvoltage occurs, the protection device is activated to prevent the measuring element from breaking. In this case, the analysis runs interrupted, but the detector itself can continue to be used.

3. Small size and flexible configuration of micro detectors

Runge MikronThe diameter of the series of miniature detectors is only32 mmThe length is115to128 mmSuitable for installation in instruments with limited space. Modular design supports adjusting detection configurations by replacing filters, light sources, and flow cells.

4. Micro detectorUSB-CIntegrated power supply and communication

Runge MikronSeries detectors use a singleUSB-CThe port completes power supply and data communication, with driver programs suitable for multiple chromatographic software packages, and open protocols that also support customized integration.

5. Specialized deaerator for nanofluidic applications

DEGASi® PLUS NanoandDEGASi® PLUS ultraNanoProvide separately25 µLand6 µLThe internal static liquid volume is designed specifically for ultra-low flow liquid systems, which can eliminate the impact of microbubbles on the accuracy of nanofluidic systems.

6、 Main applications

1. Sugar and carbohydrate detection

Differential refractive index detection does not rely on chromophores, and most carbohydrates and carbohydrate compounds lack UV absorption, thereforeRIDetectors for these substancesHPLCIt is widely used in analysis.REFRACTiMASTER®Can be used for the detection of monosaccharides and complex carbohydrates samples.

2. Analysis of alcohols, fatty acids, and polymers

Compounds such as alcohols, fatty acids, and synthetic polymers also lack UV absorption,RITesting is one of the commonly used methods for detecting the above-mentioned samples.REFRACTiMASTER®Can be found in the above substancesHPLCProvide detection signals during analysis.

3. Nanofluidic system

Biotech Micro Flow MeterApplicable to Nasheng/Minute level micro flow range, coordinated withDEGASi® PLUSThe series of online degassing machines can be used for nanofluidic applications such as chromatographic separation, sample distribution, drug screening, nucleic acid sequencing, and tissue culture.

4. Expansion of detection function for preparing liquid chromatography system

Runge Mikron 71Fluorescence detectors can provide detection extensions for preparative liquid chromatography systems that do not have fluorescence detection capabilities themselves. The compact size of the detector allows it to be installed in systems with limited space, detecting proteins as low as nanomolar levels.

5. Online chromatography processpHmonitoring

Runge Mikron 91 pHThe detector is suitable for analytical and preparation grade liquid chromatographypHOnline monitoring and simulation of moving beds（SMB）Application and continuous biological treatment processespHControl. The detector has biocompatibility and can be used inUSP Class VIUsed in a clean room environment.

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