PreciseInhale ex vivo lung perfusion module

PreciseInhale ex vivo lung perfusion moduleIt is a specially customized IPL version used to expose inhalable aerosols from PreciseInhale, providing low standard deviation dose rates (typically<10%) and high-resolution data.

IPL has great value in describing the non respiratory functions of lung tissue, such as lung metabolic activity and the response of different components of the lungs to suspended particles or drug components in the air. It is a mature experimental model in toxicology and pharmacology research.IPLCan be researchedStudy the specific effects of toxins and drugs on the lungs, as they do not involve blood circulation in the distal compartment.

This module needs to be compatible withPreciseInhale gasSol generatorCombined with usage, as shown in the figure below, each module and host are produced by Inhalation Sciences Sweden AB (ISAB), an innovative instrument listed company headquartered in Sweden that provides analytical instruments and research services. Its products are mainly used for aerosol and inhalation formulation research.

PreciseInhale ex vivo lung perfusion moduleThe advantages and main performance are as follows:

• withSingle way mode perfusion is particularly beneficial for pharmacokinetic (PK) studies of inhaled drugs and toxins
  

• Collect the infusion fluid using a fraction collector throughout the entire infusion period, making it possible to monitor the flow rate of the infusion fluid

• Can be converted to recirculation mode to facilitate the detection of accumulated substances or their metabolites in smaller perfusion volumes
  

• Sample collection time of more than 2 hours, detailed description of lung absorption and retention

• Ex vivo lung perfusion module (IPL) administration deviation<10%

• Detecting potential acute organ toxicity at the earliest possible time point

• Equipped with high-precision balance to control the total mass balance without loss