Osteopontin (derived from cow's milk)

Osteopontin (derived from cow's milk)106441-73-0>95(PAGE)10mg 100mg 1g

Osteopontin (OPN) is a negatively charged, highly phosphorylated, and glycosylated protein with an isoelectric point of 3.6, containing an RGD (Arg Gly Asp) sequence.

The content of osteopontin in cow's milk is 18mg/L, and much higher in human milk, reaching 138mg/L, with significant individual differences. The glycosylation modification of osteopontin is mainly based on O-glycans, with a high proportion of sialylation, so it can also be called sialic acid glycoprotein. The content of osteopontin varies greatly in breast milk of women from different countries and individuals (18-322mg/L), with the highest content in colostrum, playing an important role in the early development of infants and young children

Osteopontin (OPN) is a multifunctional glycosylated phosphoprotein belonging to the extracellular matrix protein family.

Osteopontin was originally named after its expression in bones, but later it was found to be expressed in various tissues and cells, including skin, kidneys, blood vessels, immune cells, and more. Its main functions involve cell adhesion, migration, signal transduction, immune regulation, and other aspects. Osteopontin participates in various biological processes of cells by binding to integrin receptors on the cell surface. In addition, osteopontin is also associated with the occurrence and development of some diseases

Osteopontin (derived from cow's milk)106441-73-0>95(PAGE)10mg 100mg 1g