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Nanjing Kebai Biotechnology Co., Ltd
Mouse FCGR4 CHO
NegotiableUpdate on 05/06
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Overview
Mouse FCGR4 CHO
Product Details
Mouse FCGR4 CHO
| I. Background | |
| FCGR4 基因（CD16-2/FcγRIV）位于小鼠染色体 11q13.3，编码低亲和力 IgG Fc 受 体，对 IgG2a/IgG2b 具有中等亲和力，参与抗体依赖性细胞毒性（ADCC），在脾树突状细胞中促进抗原呈递，增强 CD4+/CD8+ T 细胞免疫应答，并介导中性粒细胞激活及破骨细 胞分化，影响骨吸收。该基因还与 IgE 结合，促进巨噬细胞吞噬、T 细胞抗原呈递及过敏反应。此外，FCGR4 与动脉粥样硬化相关，CVI 抗体可诱导 Ly6a+Fcgr4+单核细胞增加，促进斑块消退。其功能机制涉及与 ITAM 信号亚基（如 FCER1G）形成复合物，激活 Src/Syk 激酶通路，调控免疫反应及炎症过程，在自身免疫性疾病（如 IgG4 相关疾病）及 治疗中具有重要研究价值。 | |
| II. Description | |
| Mouse FCGR4 CHO 细胞，在 CHO-K1 细胞的基础上，稳定表达鼠 FCGR4。 | |
| III. Introduction | |
| Expressed gene: | Mouse FCGR4 |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+ 10% FBS + 5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
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