Microfluidic high-throughput microbioreactor

NegotiableUpdate on 02/21

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Nature of the Manufacturer: Producers

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Overview

BioLector Pro is an advanced micro bioreactor system developed by combining existing BioLector technology with innovative microfluidic chips. The system operates using standard microplates in conjunction with non-invasive optical sensors. BioLector Pro uses a disposable 48 well microplate with the ability to measure biomass, fluorescence, pH, and dissolved oxygen (DO) data online. It can also control pH and feed rate through microvalves and microfluidic channels.

Product Details

BioLector Pro microfluidic high-throughput microreactor
BioLector ProBy integrating the existingBioLectorAn advanced micro bioreactor system has been developed by combining technology with innovative microfluidic chips. The system operates using standard microplates in conjunction with non-invasive optical sensors.BioLector ProAdopting one-time use48Microporous plate with online measurement of biomass, fluorescence, and acidity/alkalinity(pH)And dissolved oxygen value(DO)The function of data can also be controlled through microvalves and microfluidic channelspHAnd the feeding rate. This microfluidic board is very unique and can achieve continuous feeding andpHcontrol,No need to install pipelines and liquid handling equipment,And it has been pre sterilized with gamma rays.

application
•fed-batch
•pHanalysis
•Optimization of feeding rate
•Screening and optimization of culture medium
•Fermentation parameter optimization
•Screening of bacterial strains and cell lines
•Anaerobic and microaerophilic fermentation
•Synthetic Biology and Systems Biology
•Experimental Design(DoE)
•Growth characteristic analysis
•High throughput protein expression
•Enzyme and cell activity testing
•functional genomics
•Proteomic research
•Growth inhibition and toxicity testing
•quality control

on-line measurement
•Biomass concentration
•pHprice
•dissolved oxygen value(DO)
•riboflavin
•Fluorescent molecules (green fluorescent protein, yellow fluorescent protein, red fluorescent protein, etc.)
•temperature
•humidity
•The top spaceO2
•The top spaceCO2

performance
•The working volume is800–2400μL
•32A parallel microreactor
•16A storage hole
•independentpHcontrol
•Independent continuous feeding
•kLaWide range of values(25–600 1/h)
•Continuous gas exchange and oxygen supply
•The input power of each reactor is equal
•Established process parameters and scalability
•Gas environment control（CO2、O2andN2）
•Feeding mode: constant, linear, exponential or signal triggered

on-line control
•pHprice
•Supplement materials
•Vibration frequency
•temperature
•humidity
•The top spaceO2
•The top spaceCO2

advantage
•yes32Real time dynamic monitoring of parallel fermentation
•Standard microporous plate(MTP)Micro fermentation of formula
•Batch and feeding batch fermentation
•on linepHcontrol
•Online continuous feeding
•DOSignal triggered replenishment
•lowpHValue measurement range3.6-6.5
•High throughput and automation
•Wide range of biomass detection (up to equivalent to250 OD600，
50g/L CDWUsing Escherichia coli as the measurement object
•Biomass detection can be performed online without dilution
•Small size(800–2400 _L)
•No edge effect
•Continuous vibration operation (without manual intervention)
•Established mass transfer conditions
•Can be scaled up to the scale of a desktop fermentation tank
•data analysis software
•be beneficial forPATandQBD

Measurement Example

technical specifications