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Meide Sheng Rezafungin MIC drug sensitivity paper strip

NegotiableUpdate on 01/06

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Nature of the Manufacturer: Producers

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Overview

Meide Voice launches the MIC drug sensitivity paper strip of Rezafungin, a cutting-edge member of antifungal drugs

Product Details

Rezafen Jing（Rezafungin）He is a rising star in the field of antifungal drugs, briefly described as follows

feature	description
Drug category	Echinococcin antifungal drugs
mechanism of action	Non competitive inhibition1,3-beta-β - glucan synthase, which destroys fungal cell walls
Core strengths	Long lasting effect: with a half-life of approximately133Hours, allowing weekly administration, DIAN replaces the traditional mode of daily administration of echinocandin
Main indications	Adult candidemia and invasive candidiasis
Efficacy verification	IIIPhase clinical trials（ReSTORE）Confirmed that its efficacy is non inferior to the standard treatment drug caspofungin (once daily) in the primary endpoint
Drug susceptibility testing	Provide clear medication guidance for clinical doctors, especially for strains such as Candida albicans and Candida auricula that are prone to drug resistance or highly resistant

💊Epidemiological and treatment challenges faced

Invasive Candida infection（ICIs）The epidemiology of COVID-19 has undergone significant changes in the past few decades, mainly reflected in:

→ Changes in bacterial strainsThe source of infection is increasingly shifting from traditional Candida albicans tonon-albicans candidaSpecies such as Candida albicans and Candida auricula are typically more resistant to antifungal drugs.

→ high mortality rateDespite treatment options, the mortality rate of invasive candidiasis remains high, reaching up to30%-40%It is a serious threat to the lives of critically ill patients.

Treatment dilemmaThe existing drugs have limitations, such as requiring daily intravenous administration, which poses challenges to medical resources and patient compliance.

💎Summary and Outlook

Overall, Reza Fenjing relies on itsLong term weekly effectThe administration method and good efficacy and safety demonstrated in phase III clinical trials provide a new important option for the treatment of invasive Candida infections.

ButDrug sensitivity testing is the "eye" that ensures the scientific and rational use of this new drugBy guiding clinical medication through drug sensitivity testing, ZUI can maximize the therapeutic potential of remifentanil and cope with the increasingly severe drug resistance

Li FeichiRezafen net drug sensitivity test strip[Rezafungin]

Virtue voice provides benefits for gallopingRezafen JingMICDrug sensitive paper strips;Used to determine the minimum inhibitory concentration of Candida species, especially multidrug-resistant Candida, against the novel antifungal drug remifentanil.

parameter	Instructions
Applicable microorganisms	Candida genus
Recommended culture medium	RPMI agar
Inoculation concentration	0.5 McPherson units
Incubation conditions	35 ± 2 ° C, ambient atmosphere, 24-48 hours

quality control
To ensure the accuracy of the test results, this product uses standard strains for quality control, and its MIC value should fall within the expected range:

Quality control strains	expectationMICscope(μg/mL)
Candida krusei ATCC 6258	0.015 - 0.12
Candida parapsilosis ATCC 22019	0.25 - 2

performance verification:Compared with the reference method (broth microdilution method), this product exhibits high accuracy.

Verify Microorganisms	Number of tested bacterial strains(N)	Basic consistency
Candida genus	101	95.2%

Note: Basic consistency is defined as the results obtained from two methodsMICValue in±1Consistently within a two-fold dilution.

Rezafen Net Reading Guide
Attention: Read the MIC value as the 80% inhibition point

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Order Information

Product Number	Product Name
92091	RezafunginMICDrug sensitive paper strips(0.002-32,30article/box)
920910	Rizafungin MICDrug sensitive paper strips（0.002-32,100 pieces/box)

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