Laser particle counter

Laser particle counterIntroduction:

It integrates fully automatic detection functions such as automatic sampling, automatic dilution, automatic detection, data processing, and automatic cleaning, providing users with convenient, fast, efficient, and reliable particle size analysis. The LE series sensor it is equipped with adopts advanced single particle optical sensing technology (SPOS), with 512 channels of ultra-high resolution, and is equipped with a two-step automatic dilution system with technology, which can truly test and count the particle size of a large number of particle samples. The sample concentration can reach 1011 #/ml, and the particle size detection range is 0.5 μ m-400 μ m.

Independent experiments have shown that APS has a sensitivity 1500 to 25000 times higher for detecting large particles in the slurry used in the electrochemical polishing (CMP) process than traditional laser scattering methods. ButIn the Chinese Pharmacopoeia CP2015, this instrument is also used as a detection instrument for large milk particles (PFAT5) in emulsions. Similarly, this instrument can be applied in industries such as ink, pigments, pigments, and complex drug injections, all of which share a common feature - a small amount of "tail" large particles are an important criterion for determining the success or failure of a product.

Laser particle countertechnical advantage

1. Two automatic dilutions, suitable for samples with higher concentrations

2. Compliant with 21CFR regulations software - compliant with cGMP requirements;

3. On site calibration, no need to return to the factory;

4. Modular design, easy to upgrade and maintain;

5. 512 channels, no fine particles are missed;

6. Meets the requirements of USP729 and CP of the Chinese Pharmacopoeia, and can customize reports and standards;

7. Integrating automation functions such as automatic sampling, automatic detection, data processing, and automatic cleaning;

512 data channel

For a particle counter, the more channels it has, the more areas it divides within a specific measurement range. The AccuSizer 780 particle counter series instruments have 512 channels divided by exponential levels for the measurement range of 0.5 μ m-400.0 μ m, meaning that the range is finer at smaller particle sizes, for example: 1.586 μ m-1.675 μ m. The advantages of doing so are obvious. On the one hand, the instrument achieves precise counting, allowing for detailed analysis of the measured results rather than rough classification. On the other hand, for measuring complex systems and multi-component samples, the data can be well reflected in the result spectrum and data.

The above four images show the performance of the same sample when using different channels. It is obvious that when using 8, 16, and 32 channels, only the particle size can be determined within a certain range, and the exact size cannot be determined. After switching to the 512 high channel, the discrimination of particle size significantly increased, and the judgment of peak values became clearer and more distinct.

high resolution

The advantage of high channel results in the advantage of high resolution. The so-called resolution here refers to the ability to distinguish different particle sizes within the same system. Thanks to advanced design concepts and a combination of software and hardware, the AccuSizer 780 series instrument not only presents particle counting distributions that are different from classical light scattering, but also has higher resolution and accuracy compared to classical resistance and photoresist methods. It will not miss any "tail" large particles, which are often the criteria for determining the quality of the product.

Optional 21CFR Part 11 regulatory software - compliant with cGMP requirements

The AccuSizer 780 A7000 APS insoluble particle detector is equipped with software that meets the requirements of 21 CFR PART11 in the United States. It has multiple functions such as automatic data backup, audit tracking, permission grading, electronic signature, and the ability to connect to the Lims system.

The China Food and Drug Administration (NMPA) has a policy trend to implement standardized GLP management for pharmaceutical research and development enterprises. Using software that complies with 21 CFR PART 11 regulations is more in line with current GLP/GMP requirements.