Large scale production type ultrafine crusher technology:
Shandong Sanqing, with advanced technology, specializes in manufacturing ultrafine crushers, low-temperature crushers, and cell wall breaking machines, which are trustworthy.
Cordyceps sinensis and other materials that require cell wall breaking have a cell wall breaking rate of over 99%, zero loss, melt upon entry, increase human absorption rate several times, save costs, and maintain low temperature quality.
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Technical characteristics of micro powder machine
1. The crushing process is fully enclosed and non graded (preservation of drug components)
2. Effective compression and crushing method (increased bioavailability brought by precision compounding)
3. Unit operations before and after the process, quality control and GMP, other (standardization of equipment)
Working principle of large-scale production type ultrafine crusher
Under the action of external excitation force, the grinding medium undergoes a throwing motion that sometimes disperses and sometimes aggregates. The grinding medium itself rotates in the same direction, while the grinding medium group revolves. The inner and outer grinding media constantly exchange positions, and the two grinding media constantly collide, squeeze, and shear the material, causing it to be crushed and sheared. The particles are constantly broken from large to small. During the crushing process, larger particles are subjected to force first and are crushed first.
According to the working principle, particles composed of plant cell groups, whether composed of large cells or small cell groups, have equal opportunities for compression and impact as long as their overall size is comparable. In the process of crushing medicinal herbs, whether it is a large cell group or a small cell group, as long as their overall size is equivalent, the probability of being crushed is the same.
Solved various problems in crushing operations
The process application centered on cell level micro pulverization technology provides broad application space for innovation in traditional Chinese medicine pharmaceutical technology.
1. Solved various problems in traditional Chinese medicine crushing operations
Strong fibrous (such as Ganoderma lucidum, licorice, etc.), high sugar and high viscosity (such as wolfberry, Ophiopogon japonicus, etc.), resin based (such as frankincense, myrrh, etc.)
Strong resilience (such as antelope horns, seahorses, etc.), animals (such as scorpions, leeches, etc.), minerals (such as cinnabar, cinnabar, etc.)
2. Reform of traditional Chinese medicine dosage forms, improvement of efficacy, reduction of dosage, and enhancement of micro powder technology level
New Chinese medicine micro powder decoction pieces 300 mesh raw powder soft capsule preparation (ginseng soft capsule)
One step preparation of ointment (Liuwei Dihuang soft capsules) transdermal (membrane) preparation
Realize granulation and compression rate without or with minimal auxiliary materials (known as Ershu) (minimum 6L equipment: 25Kg of cinnabar per hour)
To reduce the dosage and improve the therapeutic effect (Bawei Dihuang Wan), reduce the dosage by 80% -90%, and reform the traditional Chinese medicine decoction (Tiaoxin Tiaowei Tang)
Reduce the consumption of medicinal herbs (raspberry reduces loss by 20%), crush them at low temperature for preservation, and use fresh Chinese herbs and animal tissues (such as black chicken and crab)
Spray preparation achieves compounding and precision coating better than ± 1 ‰ uniformity (artificial bezoar)
The excellent characteristics and special performance of large-scale production ultrafine crushers
AHigh crushing efficiency:Suitable for any fibrous, high toughness, high hardness, and moisture content less than 6% material, with low energy consumption and low temperature, avoiding high-temperature oxidation, deterioration, and loss and segregation of active ingredients. Crushing processFully enclosed and dust-freeOverflow, fully improving the working environment.
B、Strong crushing ability： Crush without residueSuitable for both dry and wet crushing, water, alcohol, or other solvents can be added during wet crushing.
Suitable for crushing requirements with a central particle size of 150 mesh to 10000 mesh (1.3 μ m), and can reach 1 to 0.1 μ m when using special processes. Materials that require breaking the cell wall of spores such as pollen and Ganoderma spore powderThe wall breaking rate is higher than 95%.
C、GMP design:Designed according to GMP standards and made of stainless steel that meets the requirements of pharmaceutical and food standards,The contact area with the material isPolished stainless steel，The internal corners and arcs are excessive, and the fully enclosed operation has no dust pollution or material loss.
DEasy to operate:Compact and reasonable structure with small footprint, no need for air compressors, conveying pipelines, dust removal and collection devices, and can be put into operation by connecting water and electricity. Easy to assemble, disassemble, and replace materials; Can be cleaned and disinfected with water, starch, alcohol, etc; Equipped with a composite soundproof cover, the production noise is low.
EEasy to operate:Low labor intensity, easy to operate, convenient for disassembly, cleaning, and daily maintenance.
FComplete range of models:There are both large and medium-sized equipment suitable for industrial production, as well as small equipment suitable for small-scale production or scientific research experiments.
GApplication scope:Suitable for animals (plants), mineral medicinal materials, and (health) food raw materials with different species characteristics and significant differences, such as materials with toughness, brittleness, high (low) hardness, high fiber content, high oil content, or high sugar content.
HAppearance:Stainless steel fully enclosed, made of matte stainless steel plate.
I、Precision coating：Can produce particles of two or more materialsPrecision compounding and coatingHigh solid content, strong homogenization, and super emulsification operations.
JLow temperature quality crushing, crushing fresh Chinese herbs and animal fresh tissues.
KTemperature controllable：The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. When low-temperature crushing is required, a refrigeration system should be configuredThe minimum temperature can reach -45 ℃.
Other process application methods
1、 Application in the cosmetics industry: After micro crushing the cell wall, the super effect time is shorter, the absorption is more complete, the efficacy is more comprehensive, and the effect is more obvious. Some fresh medicines can also be crushed and directly made into cosmetics.
2、 Application in the animal medicine industry: Micro powder technology is an effective means of implementing green animal medicine. (Traditional Chinese medicine) animal medicine can effectively improve efficacy, reduce costs, solve drug residues, and improve safety after cell wall breaking. Chinese medicine micro powder quickly disperses and suspends in water, and is supplied to livestock for normal drinking through an automatic water dispenser, effectively solving the problems of drug precipitation and uneven dosage that lead to reduced efficacy.
3、 Application of precious fine materials
4、 Precision mixing (achieving composite and precision coating with uniformity better than ± 1 ‰)
5、 The impact on molding (including coating)
a) For tablets and capsules, improve dissolution rate and enhance bioavailability; Improve appearance and uniformity of particle content; Reduced fiber elasticity makes it easier to pelletize and compress; Increase the specific gravity of the capsule to increase its filling capacity;
b) For soft capsules, improve the mixing uniformity between the main drug and the matrix, and reduce sedimentation; Due to the increase in the particle size of the main drug, the amount of matrix used can be correspondingly reduced, thereby lowering costs; Equal volume particles, thixotropy, particle size distribution, compression crushing
c) For ointment, gel and other external preparations, improve the mixing uniformity of the main drug and the matrix; Improve the delicacy of appearance; Reduced particle size facilitates transdermal absorption and improves therapeutic efficacy.
