The company is a high-tech enterprise specializing in the production of ultra micro pulverizers (cell wall breaking machines) and micro (nano) Rice noodles technology, process, equipment and technical services. The company has combined powder technology with traditional Chinese medicine to study the characteristics and particle size of over 2000 types of Chinese medicinal materials. Through tens of thousands of wall breaking (membrane breaking) micro crushing experiments, it has accumulated a wealth of successful practical experience. The ultrafine pulverizer produced by the company has the characteristics of high pulverization efficiency, high wall breaking rate, low pulverization temperature, and fully enclosed operation; It belongs to the common technology for the preparation of micro (nano) Rice noodles and micro (nano) meter practical technical products; The particle size of the powder can reach 1-0.1 μ m, and the cell wall (membrane) breaking rate is over 98%; The application scope involves industries such as pharmaceuticals (including veterinary drugs and pesticides), (health) food, cosmetics, chemical building materials, metallurgical energy, electronic environmental protection, etc; And it has received unanimous praise and acclaim from users.
For several years, the company's experimental technology personnel have continuously conducted tens of thousands of crushing experiments for users in various traditional Chinese medicine industries across the country, including pharmaceuticals, scientific research, universities, enterprises, hospitals, etc. Nearly a thousand varieties of traditional Chinese medicine and hundreds of traditional Chinese medicine formulas have been developed, forming a complete set of cell level micro crushing process conditions for traditional Chinese medicine. Due to the diverse varieties of traditional Chinese medicine cell level micro pulverization, the subsequent units of micro pulverization are different from conventional ones. In the work, personalized analysis of raw material characteristics and user requirements is emphasized, and corresponding systems have been formed for raw material processing, subsequent preparations, packaging, storage and transportation, and other related issues.
The company has made countless modifications to the appearance, crushing effect, material adaptability, operability, maintainability, cleaning performance, noise, long-term continuous operation reliability of equipment, human factors affecting operators, regional differences, site differences, etc. of the equipment. Lay a solid foundation for the stability of product quality.
The company provides users with a complete solution that includes standard cleaning SOP, standard maintenance SOP, and standard operation SOP. It has assisted several enterprises in completing GMP validation for traditional Chinese medicine micro crushing workshops.
Technical characteristics of micro powder machine
1. The crushing process is fully enclosed and non graded (preservation of drug components)
2. Effective compression and crushing method (increased bioavailability brought by precision compounding)
3. Unit operations before and after the process, quality control and GMP, other (standardization of equipment)
Working principle of micro powder machine
Under the action of external excitation force, the grinding medium undergoes a throwing motion that sometimes disperses and sometimes aggregates. The grinding medium itself rotates in the same direction, while the grinding medium group revolves. The inner and outer grinding media constantly exchange positions, and the two grinding media constantly collide, squeeze, and shear the material, causing it to be crushed and sheared. The particles are constantly broken from large to small. During the crushing process, larger particles are subjected to force first and are crushed first.
According to the working principle, particles composed of plant cell groups, whether composed of large cells or small cell groups, have equal opportunities for compression and impact as long as their overall size is comparable. In the process of crushing medicinal herbs, whether it is a large cell group or a small cell group, as long as their overall size is equivalent, the probability of being crushed is the same.
Solved various problems in crushing operations
Strong fibrosis (Ganoderma lucidum, Astragalus membranaceus, etc.), high sugar and high viscosity (Goji berries, Rehmannia glutinosa, etc.)
Resin based materials (frankincense, myrrh, etc.) with strong toughness (antelope horn, hawksbill turtle, etc.)
Animals (scorpions, centipedes, etc.) and oils (almonds, schisandra, etc.))
The excellent characteristics and special performance of micro powder machine
AHigh crushing efficiency:Low energy consumption and low temperature, avoiding material high-temperature oxidation, deterioration, and loss and segregation of active ingredients. Crushing processFully enclosed and dust-freeOverflow, fully improving the working environment.
B、Strong crushing ability： Crush without residueSuitable for both dry and wet crushing, water, alcohol, or other solvents can be added during wet crushing.
C、GMP design:Designed according to GMP standards and made of stainless steel that meets the requirements of pharmaceutical and food standards,The contact area with the material isPolished stainless steel，The internal corners and arcs are excessive, and the fully enclosed operation has no dust pollution or material loss.
DEasy to operate:Compact and reasonable structure with small footprint, no need for air compressors, conveying pipelines, dust removal and collection devices, and can be put into operation by connecting water and electricity. Easy to assemble, disassemble, and replace materials; Can be cleaned and disinfected with water, starch, alcohol, etc; Equipped with a composite soundproof cover, the production noise is low.
EEasy to operate:Low labor intensity, easy to operate, convenient for disassembly, cleaning, and daily maintenance.
FComplete range of models:There are both large and medium-sized equipment suitable for industrial production, as well as small equipment suitable for small-scale production or scientific research experiments.
GApplication scope:Suitable for animals (plants), mineral medicinal materials, and (health) food raw materials with different species characteristics and significant differences, such as materials with toughness, brittleness, high (low) hardness, high fiber content, high oil content, or high sugar content.
HAppearance:Stainless steel fully enclosed, made of matte stainless steel plate.
I、Precision coating：Can produce particles of two or more materialsPrecision compounding and coatingHigh solid content, strong homogenization, and super emulsification operations.
JLow temperature quality crushing, crushing fresh Chinese herbs and animal fresh tissues.
KTemperature controllable：The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. When low-temperature crushing is required, a refrigeration system should be configuredThe minimum temperature can reach -45 ℃.
Other process application methods
1、 Application in the cosmetics industry: After micro crushing the cell wall, the super effect time is shorter, the absorption is more complete, the efficacy is more comprehensive, and the effect is more obvious. Some fresh medicines can also be crushed and directly made into cosmetics.
2、 Application in the animal medicine industry: Micro powder technology is an effective means of implementing green animal medicine. (Traditional Chinese medicine) animal medicine can effectively improve efficacy, reduce costs, solve drug residues, and improve safety after cell wall breaking. Chinese medicine micro powder quickly disperses and suspends in water, and is supplied to livestock for normal drinking through an automatic water dispenser, effectively solving the problems of drug precipitation and uneven dosage that lead to reduced efficacy.
3、 Application of precious fine materials
4、 Precision mixing (achieving composite and precision coating with uniformity better than ± 1 ‰)
5、 The impact on molding (including coating)
a) For tablets and capsules, improve dissolution rate and enhance bioavailability; Improve appearance and uniformity of particle content; Reduced fiber elasticity makes it easier to pelletize and compress; Increase the specific gravity of the capsule to increase its filling capacity;
b) For soft capsules, improve the mixing uniformity between the main drug and the matrix, and reduce sedimentation; Due to the increase in the particle size of the main drug, the amount of matrix used can be correspondingly reduced, thereby lowering costs; Equal volume particles, thixotropy, particle size distribution, compression crushing
c) For ointment, gel and other external preparations, improve the mixing uniformity of the main drug and the matrix; Improve the delicacy of appearance; Reduced particle size facilitates transdermal absorption and improves therapeutic efficacy.
