Laboratory emulsifying equipment 100l emulsifier

Immunological detection technology has been widely used in monitoring harmful substances in food and agricultural products, diagnosing human and animal diseases, and providing strong technical support for ensuring consumer safety and physical health of the Chinese people. The one-step antigen immunization in antibody preparation is a key step in immunological detection technology. Before antigen immunization, the antigen generally needs to be emulsified with an immune adjuvant such as Freund's adjuvant to form a "water in oil" emulsion, and then injected for immunization.

The main functions of immune adjuvants are

(1) Delaying the release of antigens, protecting them from hydrolysis, prolonging their retention time in the body, avoiding frequent injections, and promoting the production of high affinity antibodies;
(2) Activate macrophages and promote their interaction with T and B cells, thereby providing specific enhanced stimulation to lymphocytes;
(3) After the adjuvant adsorbs the antigen, it increases the surface area of the antigen, making it easier for macrophages to engulf it;
(4) Can stimulate phagocytic cells to process antigens;
(5) Can stimulate the malignant division of sensitized lymphocytes and the production of antibodies by plasma cells;
(6) Changes in the body that can enhance the initial and subsequent immune responses;
(7) Change the type of antibody production and induce delayed state reactions, and enhance them. The traditional antigen emulsification methods include grinding method, syringe mixing method, and ultrasound method. Immune antigen emulsification devices are used to inject emulsifiers

免疫用抗原乳化装置 注射乳化器

The main products of Fage Company are emulsifiers, vacuum dryers, vacuum mixers, peristaltic pumps, peristaltic pump accessories, peristaltic pump tubes, peristaltic pump heads. The main products of Fage Company are emulsifiers, vacuum dryers, vacuum mixers, peristaltic pumps, peristaltic pump accessories, peristaltic pump tubes, peristaltic pump heads

Introduction to adjuvants

When a substance is injected into an animal before, mixed with, or simultaneously injected with an antigen, it non-specific alters or enhances the body's specific immune response to the antigen, and plays an adjuvant role, it is called an adjuvant, also known as a non-specific immune proliferative agent. There are many types, and there is currently no unified classification method. Commonly used adjuvants can be divided into four categories: inorganic adjuvants, such as alum, etc; Organic adjuvants, microorganisms and their products such as Mycobacterium tuberculosis (Mycobacterium tuberculosis, BCG), Bacillus subtilis, Bordetella pertussis, endotoxins, bacterial extracts (muramyl dipeptides), etc; Synthetic adjuvants, such as artificially synthesized double stranded polynucleotides (double stranded polyadenylation, uridine), levamisole, isopropylamide, etc; Oil agents, such as Fischer adjuvant, peanut oil emulsion adjuvant, mineral oil, vegetable oil, etc. Freund's adjuvant is currently used in experimental animals and can be divided into two types: Freund's non adjuvant and adjuvant. Adjuvants are oil based paraffin oil or vegetable oil emulsifiers that are not mixed with lanolin or Tween (80). When mixed with antigens, they form a water in oil emulsion that can be used for immune injection. Adding dead mycobacteria without adjuvants is called Freund's adjuvant. The immune strength of adjuvants is greater than that of non adjuvants. And biphasic adjuvants (W/O/W) have the same antigenicity as water in oil adjuvants (W/O), are easy to absorb, more stable, have lower viscosity, are easier to emulsify, and are safe and effective.

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