LHVS

NegotiableUpdate on 05/06

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Overview

LHVS is an effective, non selective, irreversible inhibitor of cysteine protease and cathepsin in cells. LHVS can reduce the formation of actin rings. LHVS inhibits T. gondii invasion with an IC50 of 10 μ M.

Product Details

All products of MCE are only used for scientific research or drug certification applications, and we do not provide products and services for any personal use.

LHVS

MCE International Station:LHVS

Brand:MedChemExpress (MCE)

Item No.HY-128971

CAS：170111-28-1

Purity:98.03%

Storage conditions:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Transportation conditions:The room temperature in mainland America; Other places may be different.

Product activity:LHVSIt is an effective, non selective, irreversible inhibitor of cysteine protease and protease that can penetrate cells.LHVSCan reduce the formation of actin rings.LHVSInhibition of T. gondii invasion, with an IC50 of 10 μ M.

Biological activity:LHVSIt is an effective, non selective, irreversible, and cell permeable inhibitor of cysteine protease and tissue protease.LHVSReduce the formation of actin rings.LHVSinhibitionT。 gondiiintrusion,IC₅₀For 10 μ M^[1]^[2]^[3].

Outside the body:Compared with untreated osteoclasts,LHVS(5 μ M, 2 hours) can reduce actin ring formation by 50% in wild-type osteoclasts [1].LHVSActing on osteoclasts in a dose-dependent manner, at 5 μ M,LHVSCan inhibit proteases K, L, S, and B [1].LHVS(1-5 nM) can specifically inhibit protease S in HOM2 cells, while other cysteine proteases maintain functional activity [3].LHVSDamaging tachyzoite attachment by preventing the release of at least two key invasion proteins, MIC2 and M2AP, by mitochondria.LHVS(50 μ M) can selectively impair the secretion of microtubule proteins [2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inside the body:LHVS(3-30 mg/kg, SC, once) has anti hyperalgesia effects on rats [4].LHVS(30 nmol/rat, spinal cord administration, once daily) has an anti injury effect on rats [5].LHVS(1-50 nmol/rat, intrathecal injection, once daily) can reverse the mechanical hyperalgesia formed in 14 day old rats [5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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References:

[1]. Wilson SR, et al. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23; 284(4):2584-92.
[2]. Teo CF, et al.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrob Agents Chemother. 2007 Feb; 51(2):679-88.
[3]. Riese RJ, et al. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 1996 Apr; 4(4):357-66.
[4]. Barclay J, et al. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain. 2007 Aug; 130(3):225-234.
[5]. Clark AK, et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10655-60.

Brand Introduction:
MCE (MedChemExpress) has over 200 compound libraries, and we are committed to providing cutting-edge, high-quality small molecule active compounds to our research clients;
Over 50000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease fields;
The product range covers various recombinant proteins, peptides, commonly used reagent kits, as well as specialty products such as PROTAC and ADC, which are widely used in scientific research projects such as new drug development and life sciences;
Provide professional technical services such as virtual screening, ion channel screening, metabolomics analysis, drug screening, etc;
• Equipped with a professional experimental center and strict quality control and verification system;
Provide quality inspection reports such as LC/MS, NMR, HPLC, chiral analysis, and elemental analysis to ensure the high purity and quality of the product;
The biological activity of the product has been verified through experiments with customers from various countries;
Multiple top journals such as Nature, Cell, Science, and pharmaceutical patents have included the research achievements of MCE clients;
A professional team tracks the progress of new pharmaceutical and life science research, providing you with the world's new active compounds;
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