LC-MS triple quadrupole liquid chromatography-mass spectrometry

LC-MS triple quadrupole liquid chromatography-mass spectrometryIntroduction to API4000:

1. API 4000 ™ LC/MS/MS system is a new industrial standard for various stages of drug development

2.API 4000 ™ The LC/MS/MS system establishes high-performance, availability, and reliability standards for the pharmaceutical industry, providing highly sensitive results for drug development. The system's excellent anti contamination and high-throughput characteristics improve laboratory work efficiency.

3.API 4000 ™ The system can meet the challenges of strict drug development. The sensitivity of the mass spectrometry system Z ensures a low detection limit for the analysis of ultra trace substances, such as the detection of pesticide and veterinary drug residues in food safety and environmental analysis, as well as trace analysis in forensic toxicology and clinical research.

4.API 4000 ™ The LC/MS/MS system provides excellent quantitative and qualitative results for the analysis of low content compounds in complex matrices.

5. Plug and play probe: Easy to use Turbo V ™ The ion source allows rapid switching between atmospheric pressure chemical ionization (APCI) and electric spray ion source (ESI). 7. Innovative Turbo V ™ Ion source: Excellent detection limit improves ion transport rate, reduces chemical noise, enhances gas dynamics, can be used for low concentration quantitative analysis, and can also meet different flow rate requirements of LC, with a maximum flow rate of up to 3 ml/min.

6.Turbo V ™ Ion source improvement laboratory results: API 4000 ™ Turbo V system configuration ™ The ion source uses embedded ceramic heating technology and improved gas dynamics technology to increase the ionization efficiency of the sample. Improve ionization efficiency in the gas phase, thereby enhancing the sensitivity of the system. Turbo V ™ The dual channel auxiliary heating gas design can meet various flow rate requirements of the liquid phase, with a maximum flow rate of 3 ml/min. It can also improve the sensitivity of the system by up to 10 times

7. Anti pollution ceramic interface

8. Anti pollution, easy to operate: API 4000 ™ Configuring a new type of APCI probe in the system can significantly reduce peak tailing caused by cross contamination and other chemical noise factors. In APCI ionization mode, due to the rapid evaporation of the sample at high temperatures, residual energy caused by adsorption is eliminated, greatly preventing thermal degradation of the sample and effectively eliminating ion suppression phenomena, thereby improving sensitivity. The self-cleaning design of the probe improves the anti pollution ability of the ion source, ensuring that the system can continuously analyze for a long time and has good repeatability.

9. Collision Pool Design: API 4000 ™ Configure LINAC with Z-technology in the system ® High pressure collision pool ensures maximum ion transport efficiency during MS/MS scanning. LINAC ® Collision pool technology ensures that the system reduces dwell time without sacrificing sensitivity during all MS/MS scans (MRM scan, parent ion scan, daughter ion scan, neutral loss scan), thereby achieving rapid scanning. When conducting quantitative analysis, LINAC ® The collision pool technology can ensure that more than 300 ion pairs can be established for quantitative analysis in the same mass spectrometry method (MRM), thereby completing the analysis of multiple components; When conducting qualitative analysis, LINAC ® The collision pool technology ensures that the system can perform fast mother ion scanning and neutral loss scanning while maintaining high sensitivity and resolution.

10. Reliable digital pulse detector API 4000 ™ The system is equipped with a highly sensitive digital pulse detector, which can provide reliable and consistent quantitative results over a wide dynamic range for a long time. Has good intra day and inter day quantitative reproducibility results; Even for samples that are difficult to determine, reliable method validation data can be quickly provided.

Introduction to the API4000 system of LC-MS triple quadrupole liquid chromatography-mass spectrometry

1.Analyst ® Quantitative software, Analyst based on Windows operating system ® Software is a high-throughput quantitative industry standard. Analyst ® Software enables laboratories to work in various regulatory environments, providing convenient database retrieval and data traceability; It also meets all the requirements of FDA 21 CFR Part 11, including complete and varying levels of safety, audit trail, and electronic signature. The core functions of the software ensure that users can set, tune, collect, browse, and quantify data, and obtain accurate results from various complex matrix samples.

2.Analyst®

LC-MS triple quadrupole liquid chromatography-mass spectrometryThe software provides automated methods for development, data analysis, browsing, and reporting tools:

(1)Quantitative optimization is a simple method for optimizing the analysis of multi-component compounds.

(2)Intelligent integration is a new type of integration method with no parameter operation rules, which saves time in modifying and checking results.

(3)Centralized security management is flexible and easy to use, providing users with good security mode management in a regulatory environment on the same control platform for their laboratory.

(4) The audit trail function of * is complete and easy to manage, providing users with secure audit trail at all levels.

(5) Quick browsing of chromatographic peaks in slide mode

(6) Clear result layout in graphical mode

(7) Network collection collects data through the network, which can avoid manual file management and improve data security.

(8) Support users' workflow LIMS to data processing tools,

Analyst ® The software can be flexibly compatible with the user's input environment.

LC-MS triple quadrupole liquid chromatography-mass spectrometry API4000