Jiangsu supplies medicinal polyethylene glycol 4000 at a proxy price

1、 Application in oral preparations

1. Laxative (laxative effect)

• core function：
  By increasing intestinal osmotic pressure, retaining water, softening feces, promoting intestinal peristalsis, and relieving constipation.

• dosage form：

• Oral powder (such as PEG 4000 powder): directly dissolved in water and taken, commonly used for chronic functional constipation and preoperative intestinal cleansing.

• Compound preparation: Compound with electrolytes (such as *, sodium chloride) to form intestinal lavage fluid (such as PEG electrolyte powder), used for intestinal preparation before colonoscopy.

• Advantages of Function：

• Not absorbed by the intestine, high safety, and less likely to cause electrolyte imbalance (compared to traditional laxatives such as magnesium sulfate).

• Mild in effect, less likely to cause abdominal pain or dependence, suitable for long-term use (such as constipation in the elderly and pregnant women).

2. Excipients for tablets and capsules

• Application scenarios：

• adhesiveUsed to increase particle viscosity and improve compressibility during wet granulation (especially suitable for hydrophobic drugs).

• lubricantReduce the friction between the material and the die during the tablet pressing process to prevent sticking (often used in combination with magnesium stearate).

• porogen: Adjust the porosity of the membrane in the slow and controlled release coating to control the drug release rate (such as in combination with ethyl cellulose).

• example：
  In acetaminophen tablets, PEG 4000 as a binder can improve the formability of the particles and also enhance the disintegration speed of the tablets.

2、 Application in injectable and ophthalmic preparations

1. Injection cosolvents and stabilizers

• Applicable drugs：

• Fat soluble drugs (such as paclitaxel): increase drug solubility by forming hydrogen bonds or micelle solubilization.

• Protein drugs (such as interferons): used as freeze-drying protectants to prevent protein denaturation during the freeze-drying process.

• mechanism of action：
  The long-chain structure of PEG 4000 can encapsulate drug molecules, reduce their aggregation, and increase the stability of the formulation through steric hindrance effect.

2. Eye preparation thickener

• Application scenarios：

• Artificial tears: increase the viscosity of tears and prolong the residence time of drugs on the ocular surface (such as PEG 4000 combined with sodium hyaluronate).

• Eye drops thickener: reduces drug loss and improves bioavailability (such as used in antibiotic eye drops).

• advantage：
  Non irritating, good biocompatibility, can reduce the risk of ocular surface inflammation.

3、 Application in topical preparations and suppositories

1. Ointment and cream base

• Function characteristics：

• Water soluble matrix: miscible with water, easy to clean, suitable for exudative skin lesions (such as eczema ointment).

• Moisturizing agent: Absorbs and locks in moisture, improving dry skin (such as adding PEG 4000 to urea cream).

• Formula advantages：
  Compared to oil-based matrices, PEG 4000 matrix has no greasy feeling and a faster drug release rate.

2. Suppository base

• Application scenarios：

• Suppository: As a water-soluble matrix, it has a suitable melting point (about 55-60 ℃) and can quickly melt and release drugs at body temperature (such as ibuprofen suppositories).

• Vaginal suppositories: regulate hardness and melting time, while also providing lubrication (such as antifungal suppositories).

• technical advantage：
  The melting point and release rate of suppositories can be controlled by adjusting the ratio of PEG 4000 to low molecular weight PEG (such as PEG 300).

4、 Application in slow-release and targeted formulations

1. Skeleton material for sustained-release formulations

• mode of action：

• Hydrophilic gel framework: after absorbing water, a viscous gel layer is formed to delay drug diffusion (such as for theophylline sustained-release tablets).

• Mixed skeleton: compounded with fat soluble materials (such as stearic acid) to regulate drug release rate (such as nifedipine sustained-release formulations).

• drug release mechanism：
  The drug is released through the dual action of dissolution and diffusion of PEG 4000 skeleton, achieving a long-lasting release of 12-24 hours.

2. Targeted formulation modification materials

• PEGylation modification：

• Surface PEGylation of Liposomes: PEG 4000 modification reduces reticuloendothelial system (RES) phagocytosis and prolongs circulation time (such as PEGylated liposomes with doxorubicin).

• Surface modification of nanoparticles: increases hydrophilicity, reduces immunogenicity, and achieves passive targeting (such as EPR effect at tumor sites).

Eye contact: Lift the eyelids and rinse with flowing water or saline solution. Seek medical attention;

Its safety can be seen from its use in wound skin repair and eye products.

Health hazards: Inhalation and ingestion are harmful to the body and have an effect on the eyes;
Precautions for operation: Provide good natural ventilation conditions. Operators must undergo training and strictly follow operating procedures. It is recommended that operators wear self-priming filter dust masks, chemical safety goggles, anti toxic work clothes, and rubber gloves. Keep away from sources of fire and heat, and smoking is strictly prohibited in the workplace.