ImageXpress Micro Confocal High Content Imaging System

ImageXpress Micro Confocal High Content Imaging System

ImageXpress Micro Confocal High Content Imaging SystemIt is currently a high content system with relatively flexible functions. Thanks to the clear characteristics of confocal imaging, experimenters can perform more accurate quantitative analysis on live cells or fixed cells. Using this system, experimenters can easily observe complex 3D models, such as 3D cell spheres, tissues, and even small model organisms as a whole, in order to further analyze more physiological related issues. This system can automatically and quickly obtain high-quality images of publication level from samples of 1-1536 microplates or tissue sections.

l AgileOptixTM technology: the core of ImageXpress Micro Confocal system - with just one click, different modes can be switched

l Expanding research fields and reaching new heights - utilizing 3D cultivation models to obtain data closer to in vivo experiments

l Visualization and precise quantification of 3D models - confocal module significantly improves image clarity and data accuracy

l againSolution to Heterobiological ProblemsSolution - Seamless integration from image acquisition to data analysis

Key Features:

1. Select a confocal module suitable for experimental needs and flux

2. Unique optical path technology can obtain high-definition images without sacrificing speed and flux

3. The research grade CMOS detector can quickly obtain statistically significant experimental data, with a large target surface design and high dynamic range (>3log)

4. Optional environmental control components, transmitted light/phase difference components, and pipette components help you expand your research field

Expand research fields and reach new heights

The use of 3D culture models to obtain data closer to in vivo experiments and complex 3D culture cell models is increasingly being used in drug development and basic research, mainly because compared with single-layer and 2D culture models, 3D models are closer to the in vivo environment and can obtain more predictive and physiologically meaningful results. The ImageXpress Micro Confocal system provides a simple and efficient method for detecting 3D models, allowing for more accurate results even when samples are grown in thick Matrigel. The system provides a flexible imaging experience that can image various types of samples, including hanging drops plates of various specifications, U-shaped round bottom microporous plates, and flat bottom microporous plates. If equipped with environmental control components, it can dynamically track and detect cell health for a long time.

Visualization and precise quantification of 3D models

The confocal module significantly improves the clarity of images and the accuracy of data

Compared with wide field imaging, confocal mode can automatically remove the background and improve clarity when capturing thick tissue samples, thereby achieving accurate segmentation and obtaining more precise data.

Improve the image quality of organizations and 3D models

• Can meet the requirements of 3D model experiments for special cells such as nerve cells and stem cells

• Software automatically removes high background from thick tissue samples

• Easy Z-axis multi-layer scanning and 3D reconstruction

High definition imaging of pattern biology

• Large target surface design, one field of view can cover the entire well of 384 well plate

• Laser hardware automatic focusing and software image focusing enable the entire board to obtain clear images

• Can perform complex image analysis and generate videos by capturing time series footage

Solving complex biological problemsplan

Seamless integration from image acquisition to data analysis

IXM-C has a complete set of integrated environmental control solutions that can explore complex biological problems with simple operational processes.

Collect images

The powerful control functions of MetaXpress high content image acquisition and analysis software enable all image acquisition and data analysis tasks to be completed in the same interface.

• Accurately control the image acquisition process to achieve better image quality

• Automatically complete the entire process of image acquisition and storage, avoiding the hassle of importing/exporting images

• A complete focusing method that can achieve precise focusing of the entire sample

• Long term imaging of live cells can detect cell proliferation, death, differentiation, and migration, as well as virus and bacterial infections and swelling

• Tumor cell metastasis, chemotaxis, drug toxicity, translocation and other biological phenomena

data analysis

noneWhether you need regular analysis or customized analysis, MetaXpress can meet your needs for fast and accurate data analysis.

• One click operation of preset modules, easy to get started, can achieve hundreds of experimental analyses

• User defined editing module, flexible application, including multiple filters and algorithms, can produce exclusive analysis methods for you

• Adaptive Backgroud CorrectTM can remove the background based on neighboring background fluorescence intensity values and perform segmentation of the target sample to achieve better segmentation results

• 2D projection imaging, including best focus, maximum, minimum, and brightness overlay projection, enables easy analysis of 3D images

• All analysis parameters can obtain the corresponding values for each cell or the average values for each field of view separately using AcutyXpressTM data statistical software. It seamlessly integrates with the database, enabling data visualization, data mining, and various fitting analyses.

data storage

Regardless of the imaging mode used, the images are uniformly saved in the MDCStoreTM professional data management system software (database).

• MetaXpressTM high content imaging analysis software can freely read data from the database and perform multiple analyses on the captured images

• The database can integrate third-party imaging systems or analysis tools to expand its application areas