Human in vitro intestinal digestion simulation device

1. Human in vitro intestinal digestion simulation device

• Segmented simulation capability：

• Small intestine simulationDynamically adjust pH value (6.8-7.4), temperature (37 ℃ constant temperature), secretion of digestive juices (pancreatic juice, bile), and peristaltic frequency to simulate the digestion process of chyme from duodenum to ileum.

• Colonic simulation(Optional): Construct an anaerobic environment to simulate microbial fermentation (such as probiotics, gut microbiota metabolism), support research on short chain fatty acid (SCFA) generation, dietary fiber degradation, etc.

• Biomimetic systems：

• Digestive fluid simulationPre prepared artificial intestinal fluid (containing enzymes and bile salts) and colon fermentation broth (containing specific microbial communities), with ingredients consistent with the human intestinal environment.

• Mechanical power simulationSimulate segmental contraction and propulsion of the intestine through peristaltic pumps or flexible chambers to restore the process of chyme mixing and transport.

2. Real time monitoring and dynamic analysis

• Multi parameter online monitoring：

• Integrated pH sensor, temperature probe, dissolved oxygen meter, pressure sensor, etc., real-time tracking of changes in intestinal environment.

• Sampling and monitoring key indicators such as nutrient release rate (such as glucose, fatty acids), drug dissolution, and microbial metabolites (such as hydrogen, methane).

• Multi time point sampling：

  Support regular sample collection during the digestion process to analyze the degradation, absorption, or conversion efficiency of target components (such as proteins, lipids, and active ingredients).

  Human in vitro intestinal digestion simulation deviceApplication field

• Food Research and Development：

• Evaluate the colonic fermentation performance of dietary fiber and the synergistic effect of prebiotics/probiotics.

• Optimize the intestinal absorption efficiency of functional foods such as sugar control products and low-fat meal replacements.

• pharmaceutical industry：

• Test the disintegration, dissolution, and sustained release characteristics of oral medications in the intestine.

• Study the targeted release effects of nano drug delivery systems and enteric coated formulations.

• Nutrition and Health Research：

• To analyze the difference of intestinal digestion in special population (such as patients with diabetes and irritable bowel syndrome).

• Explore nutrient drug interactions (such as the effect of calcium/iron on antibiotic absorption).

• Environmental and Toxicological Assessment：

• Detect the migration and toxic release of microplastics and food additives in the intestine.

• Evaluate the intestinal biosafety of new food ingredients such as insect protein and artificial meat