High throughput animal whole-body exposure system

Product Description

The Whole Body Exposure System is a commonly used experimental equipment in toxicology, pharmacology, and environmental health science research, mainly used to expose experimental animals (such as mice, rats, guinea pigs, etc.) to controlled concentrations of gaseous, vapor, or aerosol test substances through natural respiratory pathways. Compared to the nose only exposure system that only exposes the respiratory tract, the whole body exposure system allows the entire body of the test animal (including skin and hair) to be exposed to the toxic environment.

1. Simulating real exposure scenarios: The whole body exposure system is closer to simulating the exposure situations that humans or animals may encounter in actual environments, such as air pollution, chemical leaks, or drug atomization. Through whole-body exposure, the comprehensive effects of pollutants entering the body through various pathways such as the respiratory tract and skin can be studied.

2. Study the comprehensive effects of multiple exposure pathways: Inhaled substances not only affect the respiratory tract, but also enter the bloodstream and reach other target organs (such as the cardiovascular system, nervous system, liver, kidneys, etc.). Whole body exposure can provide a more comprehensive assessment of the systemic toxicity of the test substance.

Product Features

1. Multi material compatibility:

Suitable for various types of toxic substances, such as PM2.5 particulate matter, cigarette smoke, VOCs organic solvent aerosols, liquid atomized aerosols, methane and other gases, as well as dust, nanoparticles, pollen, etc., to meet different research needs.

2. Environmental parameter control and monitoring:

Equipped with a control system that can monitor and display real-time environmental parameters such as temperature, humidity, pressure, oxygen concentration, carbon dioxide concentration, and drug concentration inside the poisoning cabinet, ensuring a stable and compliant experimental environment. Ensure the accuracy and stability of the toxic concentration through a gas flow control system.

3. Data recording and tracing:

It can record various data during the experimental process, including changes in environmental parameters, exposure time, animal reactions, etc., making it convenient for researchers to access and analyze at any time. These data are of great value for evaluating experimental results, summarizing experimental patterns, and subsequent research.

4. Waste gas treatment:

Equipped with an efficient exhaust gas treatment system, it can effectively filter and purify the exhaust gas generated in experiments, remove or reduce harmful substances to a safe level, and prevent pollution of the laboratory environment and harm to the health of experimental personnel.

5. SUS304 stainless steel material:

The cabinet is made of SUS304 stainless steel material, which has good sealing and corrosion resistance, and can prevent the leakage of toxic gases.

6. Lighting control:

Built in LED lights, supporting manual switching. During the experiment, turning on the lights can clearly illuminate the cabin, making it easier to observe animal behavior and toxic reactions; If it is necessary to simulate a specific environment (such as circadian rhythm research), turn off the lights to create a dark environment, providing a basis for customizing experimental scenes.

7. UV disinfection and sterilization:

After the experiment, turn on the built-in ultraviolet lamp, and use the strong ultraviolet sterilization ability to disinfection and sterilization the space in the cabin. It can effectively kill residual pathogens and microorganisms, avoid cross contamination, and create a clean environment for the next experiment.

8. Video surveillance:

Equipped with real-time observation and playback functions. Users can check the status of animals in the cabin at any time, record animal activities, abnormal reactions, etc. during the poisoning process; Accurately capturing subtle physiological behavioral changes, supplementing intuitive basis for data analysis, making the experiment "traceable and detail free".

9. Warning light:

Alarm parameters can be set (such as toxic concentration threshold, abnormal temperature and humidity values, etc.). When the cabin environment or toxic parameters reach the set values, the alarm light flashes and the horn sounds, reminding researchers to intervene as soon as possible.

10. Spray system:

After the experiment is completed, an external water source can be used to start flushing the cabin. Quickly clean the cabin to reduce the burden of manual scrubbing for toxic residues, animal excrement, etc.

Stainless steel mesh exposed cage

Applicable fields

Core tools for toxicology research:

Assess inhalation toxicity: Determine the acute, subchronic, and chronic toxicity (including lethality, organ damage, carcinogenicity, etc.) of chemicals, drugs, nanoparticles, industrial raw materials, air pollutants, etc. through inhalation routes.

Establishing dose-response relationship: By controlling exposure concentration and time, accurately studying the relationship between exposure levels and toxic effects, providing key scientific basis for developing safety limits (such as occupational exposure limits and environmental air quality standards).

Mechanism of action research: Study how pollutants enter the body through the respiratory tract, their absorption, distribution, metabolism, excretion processes (ADME), and induce toxic mechanisms such as inflammation, oxidative stress, and gene damage.

Research on the Health Effects of Air Pollution:

Study the inducing or exacerbating effects of urban air pollutants (such as traffic exhaust, industrial emissions), indoor air pollutants (such as second-hand smoke, cooking fumes, formaldehyde), specific harmful gases (such as ammonia, hydrogen sulfide), etc. on respiratory diseases (asthma, COPD), cardiovascular diseases, neurodegenerative diseases, etc.

Occupational and Environmental Health Risk Assessment:

Assess the risks of chemical substances that workers may come into contact with in specific workplaces, such as chemical plants, mines, and dusty environments.

Assess the potential health risks of environmental pollutants to populations, especially sensitive groups such as children and the elderly.

Relatively realistic simulation of group exposure environment:

Animals can move relatively freely inside the chamber, and their behavior (such as grooming) may affect exposure (such as skin contact, oral ingestion), which to some extent simulates the coexistence of multiple exposure pathways in the real environment (although sometimes it is necessary to distinguish between primary and secondary).

Efficiency (relative to individual exposure):

One exposure chamber can simultaneously accommodate multiple animals for exposure, improving experimental efficiency, especially suitable for chronic studies that require large sample sizes.

Model Description

References

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This introduction and parameters are basic product information and may lag behind product updates. Please contact our company for specific parameters.