Animal precision dynamic inhalation exposure system

Product Description

smallAnimal precision dynamic inhalation exposure systemCan be used for rodents ( rat , mice, guinea pigswait）Yes, that's rightGas, liquid aerosol, dust aerosol, nanoparticle gassolInhalation of inhalable substances such as smoke through the mouth and nosePoison experiment.

The overall system is fully automated, with real-time monitoring of the exposed environment and the ability to achieve aerosol concentrationOnline monitoring and countermeasuresFeed control Real time online sampling of samples.Adopting high-precision control system, the uniformity and stability of aerosol concentration reach the industry standardexcellentLevel.

Product Features

1. Automated operation

Equipped with experimental management and quick parameter setting, one click startup, and automated operation.

2. Precise control (eddy current dilution method)

High precision and high-quality flow meters accurately control the gas volume of each channel; Sampling flow accuracy: 0.01L/min, ensuring measurement accuracy.

3. Assessment of actual inhalation volume in animals

The system has the function of evaluating the inhalation volume of animal drugs, displaying real-time animal inhalation volume based on actual concentration and time.

4. The exposed tower is made of 316L stainless steel material

Food grade stainless steel material, corrosion-resistant, sturdy and durable, with mirror polished inner surface,as much as possibleReduce drug adhesion.

5. Quick disassembly

Each layer is detachable for easy cleaning and can be stacked for upgrading. The base can rotate for easy placement of animals.

6. Multi channel/multi concentration compatibility

The number of channels is optional: 6 channels, 12 channels, etc., which can achieve independent control of single pore/single-layer concentration.

7. Dual cavity design (Directed Flow)

The inner cavity is filled with drug aerosols, which are directly delivered to the exposed mouth; Collect the gas exhaled by animals in the external cavity. Separate the inner and outer chambers to prevent the inhalation of gases exhaled by animals.

8. Security alarm

Environmental parameter abnormal alarm and system abnormal alarm.

9. Compliant with GLP requirements

Multi level user permission management; Audit tracking; Electronic signature; The data is traceable.

Online respiratory monitoring in conjunction with HOP

Adopting an online respiratory monitoring system, real-time monitoring of the respiratory changes of animals during inhalation administration, quantifying the different stimulating or inhibitory effects of drugs on respiration.

Applicable fields

·Drug evaluation: efficacy, pharmacokinetics, and safety evaluation of inhalation administration routes, research on inhalation immunity, safety evaluation of in vitro cell exposure, and drug screening;

·Environmental and Health Inhalation Exposure Study: Risk Assessment of Occupational Inhalation Exposure; Research on PM2.5 particulate matter inhalation exposure; Environmental and ecological inhalation exposure research; VOCs inhalation toxicity study; Health research on inhalation of exhaust gases from gasoline/diesel engines; Research on the safety of inhalation exposure to nano material particles/dust;

·Disease modeling and research: research on occupational diseases such as lung injury, lung cancer, asthma, COPD modeling, and pneumoconiosis;

·Inhalation research on pesticides and chemicals: pesticide inhalation safety evaluation, chemical inhalation safety evaluation, in vitro cell exposure safety evaluation and drug screening, hazardous chemical aerosol hazard assessment.

·Others: research on the health effects of smoking, studies on aerosol infections caused by pathogenic microorganisms, assessment of inhalation exposure hazards in special fields such as military and aerospace medicine.

Size description

Product Model

*Can provide other size specifications.

This introduction and parameters are basic product information and may lag behind product updates. Please contact our company for specific parameters.

related literature

[1]Fan Z,Zhou B,Liu Y,Sun W,Fang Y,Lu H,Chen D,Lu K,Wu X, Xiao T, Xie W, Bian Q.'Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents'. [J]. AAPS PharmSciTech.2022 Jan 6; 23(1):50. doi:10.1208/s12249-021-02191-8.

[2]Jushan Zhang,Mo Xue,Rong Pan,Yujie Zhu,Zhongyang Zhang,Haoxiang Cheng,Johan L M Björkegren,Jia Chen,Zhiqiang Shi,Ke Hao'An e-cigarette aerosol generation, animal exposure and toxicants quantification system tocharacterize in vivo nicotine kinetics in arterial and venous blood'[J].bioRxiv preprint doi.

[3]Guolin Zhao,William Ho,Jinxian Chu, Xiaojian Xiong, Bin Hu,Kofi Oti Boakye-Yiadom,Xiaoyang Xu,Xue-Qing Zhang,Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer,[J]ACS Applied Materials&Interfaces,2023-06-24,DOI:10.1021/acsami.3c05007.