High resolution flow particle imaging analyzer

SMILLA (Smart Modular Imaging Laboratory Liquid Analyzer) is a cutting-edge modular solution using high-resolution flow imaging microscopy (HiRes SIM) technology for analyzing visible and sub visible particles. Its flexible design can easily adapt to the specific needs of the laboratory, providing efficient, accurate, and reproducible analysis results.

SMILLA is equipped with multiple interchangeable modules, each designed for specific functions and application requirements. The module replacement is simple, ensuring the shortest downtime and adaptability.

After inserting the module, SMILLA will automatically detect and complete the configuration, making it a part of the system without the need for manual settings. The physical layout of the module supports customized sample flow to adapt to different application scenarios.

This modular architecture provides flexibility and supports a wide range of particle sizes (from 200 nanometers to 2 millimeters), making it an ideal choice for diverse applications in research, quality control, and industrial environments.

SMILLA's modular design not only meets current needs, but also provides adaptability possibilities for future new demands.

There are currently four types of modules available:

HiRes SIM (High Resolution Imaging) module

Cutting edge particle imaging analysis technology

The HiRes FIS (High Resolution Flow Particle Imaging Microscope) module is the core of the SMILLA analyzer and utilizes image-based particle analysis technology. Equipped with a high-performance high-resolution camera, it can accurately visualize sub visible particles in liquid samples, with a minimum size of 0.2 microns.

-Provide two camera options (12 megapixel, black and white or color camera) to meet different application needs. Both cameras have ultra-high frame rates and real-time processing capabilities, enabling fast and efficient measurements.

-Intelligent design ensures that repeatable and high-precision results can still be output under harsh conditions. Ultra short exposure time effectively eliminates motion blur and fully complies with European Pharmacopoeia standards.

-The advanced autofocus system can continuously obtain clear images without the need for a focusing ball. Innovative and replaceableAmplification moduleSupports quick switching of magnification within seconds. All modules are equipped with RFID chips that automatically recognize after installation, without the need for additional manual configuration.

-The module integrates precision, speed, and versatility, making it an ideal choice for laboratory environments that pursue reproducible results and imaging performance.This module also provides flexibility in microscopy methods: it supports high-resolution imaging of transparent or colored particles/organisms in transmitted light mode, and can also be optionally used in reflected light mode for optically dense samples. The imaging mode can be quickly switched through an intuitive software interface.

LO module

Reliable particle counting achieved by photoresist method

The LO (photoresist method) module is an orthogonal measurement method used for counting and size analysis of particles in liquid samples, and is an ideal supplement to the SMILLA HiRes SIM module image analysis technology. A single sample run can achieve two measurement techniques, improving analysis depth and operational efficiency.

-The measurable particle size range is 1 to 120 microns (depending on the flow cell of the upstream FIM module). Even in high concentration samples, the LO module can still provide robust and accurate data. Optimizing flow rate design ensures excellent resolution and precise particle detection, suitable for various challenging applications.

The LO module is the ultimate support for laboratories pursuing compliant quantitative particle analysis, while benefiting from SMILLA's modular high-performance design.

Pump module

Accurate and reliable sample transmission

The pump module provides multiple configurations, flexibly adapting to sample types, flow preferences, and flow rate requirements:

-MACRO pump: single peristaltic pump, suitable for large volume samples, recommended for bottom-up configuration.

-MICRO1 pump: single injection pump, precise measurement of small volume samples.

-MICRO2 pump: Double alternating injection pump ensures uninterrupted flow of large volume samples.

-HYBRID pump: a combination of peristaltic pump and injection pump, suitable for multiple sample types, volumes, or wide particle size range requirements.

Cleaning Module

Can achieve automatic cleaning to avoid cross contamination

The cleaning module is equipped with a built-in cleaning and rinsing system, which can automatically clean the sample port, tubing, and flow cell after each measurement. The convenient backwash function can remove clogged particles without disassembling the flow cell.

-The framework is equipped with multiple sensors to ensure reliable operation of SMILLA in standalone mode or in combination with liquid handling systems. Its special design supports flexible configuration of HiRes SIM, LO, and pump modules.

SMILLA View software

Intelligent Particle Analysis and Intuitive Control

SMILLA View is an intuitive and easy-to-use software that provides comprehensive control over all modules and enables real-time data collection and analysis. Its precise particle counting, size measurement, high-resolution single particle image and morphology data meet the requirements of pharmacopoeia for sub visible particle detection.

SMILLA View is your cutting-edge tool for efficient particle analysis, which not only accurately completes particle counting and size measurement, but also provides:High definition single particle image andComprehensive morphological feature data.

Intelligent analysis function:
✓ Intuitive particle/microbial grouping tool
✓ Multi dimensional data filtering and classification system
✓ Optimization scheme for research-oriented and quality control workflow

Compliance assurance:
•Fully compliant with 21 CFR Part 11 Electronic Data Specification
• WorkMeet all the standard requirements for the detection of sub visible particles in the global pharmacopoeia

Advantages of system integration:
• WorkCustomizable report templates
• WorkFully compatible with LIMS laboratory information management system
• WorkSeamless workflow integration achieved through modular LADS (Laboratory Analysis Data System) framework