Hamster Liver S9

Hamster Liver S9

1、 Research and Development Background

Genetic toxicity testing has been widely used in safety testing and evaluation in various fields such as food, drugs, cosmetics, and the environment. One of the more common genetic toxicity tests is the Ames test, which is a classic test for detecting chemical or drug mutagenicity. This method is mainly conducted in culture dishes and has the characteristics of simplicity, speed, accuracy, and sensitivity. It is widely used by countries around the world. 2) Chromosome aberration test: It is a basic method for detecting the influence of chemical substances on the number and structure of chromosomes. In the safety evaluation of chemical substances, in vitro CHL cell chromosome aberration and spermatogonial chromosome aberration tests are often selected to detect the effects of chemical substances on chromosomes.

In order to make the above experimental conditions closer to the metabolic situation of mammals, mammalian microsomal enzymes were added to the testing system to compensate for the lack of metabolic activation system in vitro experiments. Due to the fact that the liver is the site of metabolism and transformation of foreign compounds in the body, S9 is often prepared from liver homogenate. Currently, the commonly used method isRat liver S9orHamster liver S9.

2、 Product Description

Hamster Liver S9It is the mitochondrial supernatant of hamster liver parenchymal cell homogenate, which contains a large amount of CYPs and other drug metabolizing enzymes. It is a very useful research tool for studying the drug metabolism of compounds and investigating potential drug drug interactions. It is also an important reagent for mutagenicity testing (Ames) in food, cosmetics, chemicals, and other industries.

3、 Specification and model

4、 Advantages of S9 series products

1. Technical advantage: Apply for 2 national inventions

2. Quality advantage: Batch preparation, sterile, meets GLP testing requirements

3. Customer advantage: Cooperate with multiple domestic GLP safety evaluation institutions, provincial disease control and drug testing institutions

4. Industry advantages: Selected as a "research and selection" * reagent for Dingxiangtong 2020

5. Quality control

Each batch has been tested and has good stability between batches.

7、 Paper citation

1）Int J Environ Res Public Health. 2020 Feb 6; 17(3). pii: E1025. doi: 10.3390/ijerph17031025.

Assessment of Biological Toxicity and Ecological Safety for Urban Black-Odor River Remediation.

Xu RR1,2, Pei ZT1,2, Wang WQ1,2, Zhang M1,2, Zhang LL1,2, Zhang J1,2, Wang WQ1,2, Sun LW1,2, Zhang YM3.

2) Mutat Res Genet Toxicol Environ Mutagen. 2019 Feb; 838:22-27.doi:10.1016/j.mrgentox.2018.11.015. Epub 2018 Dec 1.

Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.

Du X1, Gao S2, Hong L1, Zheng X3, Zhou Q4, Wu J5.

3）Int J Environ Res Public Health. 2018 Sep 2; 15(9). pii: E1907. doi: 10.3390/ijerph15091907.

Evaluation by the Ames Assay of the Mutagenicity of UV Filters Using Benzophenone and Benzophenone-1.

Wang WQ1,2, Duan HX3, Pei ZT4,5, Xu RR6,7, Qin ZT8, Zhu GC9,10, Sun LW11,12.

4) J Control Release. 2018 Jun 10; 279:220-233. doi: 10.1016/j.jconrel.2018.04.034. Epub 2018 Apr 19.

Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease.

Wang P1, Zheng X1, Guo Q1, Yang P1, Pang X1, Qian K1, Lu W2, Zhang Q3, Jiang X1.