Fructose glucose extraction chromatography separation of cation and anion exchange resins made by sulfonation transformation

Fructose glucose extraction chromatography separation of cation and anion exchange resins made by sulfonation transformation；XN-5X7 resin is a spherical, fine-grained, strongly acidic styrene based cation exchange resin. This resin is a fine-grained copolymer made by improving the suspension polymerization production process of conventional cationic resin, and is produced through sulfonation, hydration, and transformation; The obtained resin is composed of complete spheres. It does not have the problem of crushing resin and has excellent kinetic performance. This resin has excellent performance in chromatographic separation, such as rare earth element separation, fructose and glucose separationChromatography separation skill is a widely used natural product separation and purification skill. Manufacturer; Tianjin Xijinna Environmental Protection Materials Technology Co., Ltd; The current research on this skill can be summarized into two aspects: practical application and theoretical exploration, but both aspects of research have some shortcomings. In terms of usage, most existing chromatography processes have the disadvantages of low processing capacity and high operating costs; The main reason is the lack of process imitation calculation methods for *. There are serious obstacles that prevent the further development of this skill. Therefore, establishing efficient, inexpensive, and concise chromatography processes and conducting modeling research on related chromatography processes have significant theoretical and practical significance. The use of macroporous adsorption resin fixed bed chromatography technology in the separation and purification of natural products aims to establish a low-cost and suitable industrial production process route. And focused on modeling and discussing the relevant chromatographic processes. Based on the nonlinear system description ability of artificial neural networks, a mass transfer kinetics model for macroporous adsorption resin fixed bed liquid chromatography optimization model and a high-speed countercurrent chromatography optimization model were separately established to further simulate the calculation method of the chromatographic process. Established a purification process combining macroporous adsorption resin fixed bed chromatography and crystallization, and analyzed the essence of the adsorption process from a thermodynamic perspective. After optimizing the process conditions, the purification of solanesol was completed, and its purity was improved from around 50% to 94.51% in one go, indicating that the macroporous adsorption resin fixed bed chromatography technique is a feasible method for industrial production. The research results indicate that high polarity solvents and low temperature environments are beneficial for increasing the adsorption capacity of resins; Increasing the concentration of the feed solution, decreasing the flow rate, and increasing the height to diameter ratio of the chromatography column will improve the column adsorption capacity. However, a high concentration will decrease the retention time of solutes in the column bed, while a slow flow rate will prolong the loading cycle, and the longer the column, the higher the column pressure will correspondingly increase; During the elution process, as the polarity of the eluent increases, the purity of the product improves but the yield decreases. Therefore, a stepwise elution method is adopted; Thermodynamics studies have shown that the adsorption of solanesol by macroporous resins is physical adsorption, and the adsorption process can occur spontaneously. After solanesol is adsorbed by the resin, its movement is more restricted, making the system more ordered.Fructose glucose extraction chromatography separation of cation and anion exchange resins made by sulfonation transformation，The above can provide useful assistance for further applying the fixed bed chromatography technique of macroporous adsorption resin to the separation and purification of natural products.