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Shanghai Minjie Pharmaceutical Machinery Co., Ltd

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    338 Qinggao Road, Qinggang Industrial Park, Fengxian District, Shanghai

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Fermentation liquid evaporation concentrator

NegotiableUpdate on 05/07
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Overview

The fermentation broth evaporation concentrator is a specialized concentration equipment tailored by Shanghai Minjie for 25 years in the field of vacuum concentration equipment, targeting the core characteristics of high viscosity, active ingredient content, easy foaming, and heat sensitivity of fermentation broth. Integrate core technologies such as high efficiency and energy saving, low-temperature concentration, and intelligent temperature control, and strictly follow GMP standards for design and manufacturing. The equipment adopts high-quality contact materials of food grade and pharmaceutical grade, which can achieve full automation and pollution-free treatment of fermentation broth from low concentration raw material liquid to target concentration concentrated liquid. It maximizes the retention of active ingredients and effective substances in the fermentation broth, and is widely used in biotechnology, pharmaceuticals, food health, and chemical industry

Product Details

1、 Product Introduction

Fermentation liquid evaporation concentratorShanghai Minjie has been deeply involved in the field of vacuum concentration equipment for 25 years. It is a specialized concentration equipment tailored to the core characteristics of high viscosity, active ingredient content, easy foaming, and heat sensitivity of fermentation broth. Integrate core technologies such as high efficiency and energy saving, low-temperature concentration, and intelligent temperature control, and strictly follow GMP standards for design and manufacturing. The equipment adopts high-quality contact materials of food grade and pharmaceutical grade, which can achieve full automation and pollution-free treatment of fermentation broth from low concentration raw material liquid to target concentration liquid. It maximizes the retention of active ingredients and effective substances in the fermentation broth, and is widely used in the large-scale concentration production of fermentation broth in industries such as biotechnology, pharmaceuticals, food health, and chemical engineering. It is a professional solution that balances concentration efficiency, product quality, and energy conservation and environmental protection.

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2、 Working principle

Fermentation liquid evaporation concentratorWith high-efficiency and energy-saving vacuum concentration technology as the core, combined with closed-loop energy recycling design, low-temperature and high-efficiency concentration of fermentation broth is achieved. The specific principle is as follows:
  1. Feeding and pretreatment: The fermentation broth raw materials are stably transported to the concentration host through a dedicated feeding unit, and impurities are preliminarily filtered by the pretreatment system to avoid subsequent equipment blockage. At the same time, they are preheated to a suitable temperature to ensure the stability and efficiency of the concentration process.

  2. Vacuum environment construction: After the equipment is started, a stable vacuum chamber is quickly constructed to reduce the internal pressure and significantly lower the boiling point of the fermentation broth. Rapid evaporation of water can be achieved within the low temperature range of 50-75 ℃, fundamentally avoiding the decomposition and denaturation of active ingredients in the fermentation broth caused by high temperature.

  3. Energy cycle utilization: Drawing on the principle of refrigeration cycle, the energy medium completes the continuous cycle conversion of gas, liquid and gas in a closed cycle system, and synchronously releases and absorbs heat during the phase change process. The released heat energy is used for heating and evaporating the fermentation broth, while the absorbed cold energy comes from the secondary steam condensation generated by the evaporation of the fermentation broth. Through the bidirectional recovery and utilization of energy, the energy utilization efficiency is greatly improved and the energy consumption cost is reduced.

  4. Evaporation and separation: under the vacuum and low temperature environment, the water in the fermentation liquid quickly vaporizes into secondary steam, which is separated from the concentrated liquid by the high-efficiency separation device, while inhibiting the generation of foam to avoid material entrainment loss; The concentrated solution is continuously concentrated in the host to the target specific gravity, ensuring that the concentration of active ingredients meets the standard.

  5. Condensation recovery and discharge: The secondary steam is quickly condensed into liquid water through the condensation system and discharged. If the fermentation broth contains organic solvents, solvent recovery and reuse can be achieved simultaneously, improving resource utilization efficiency; The concentrated fermentation broth that reaches the target concentration is automatically output through a continuous discharge unit, with no material retention throughout the process, avoiding secondary pollution and component deterioration.

3、 Product advantages

  1. High fidelity active ingredients: The vacuum low-temperature concentration environment (adjustable from 50-75 ℃) accurately adapts to the thermal sensitivity of the fermentation broth, effectively avoiding the decomposition and deactivation of active bacteria, enzymes, bioactive substances, and other components. The activity retention rate of the concentrated product is increased by more than 30% compared to traditional concentration equipment, meeting the strict quality requirements of the biotechnology and pharmaceutical industries.

  2. Excellent energy-saving effect: adopting energy recycling technology, energy consumption is reduced by more than 60% compared to traditional concentration equipment, and operating costs are only one-third of conventional concentration processes. The single effect model consumes as little as 55-255kw/h for evaporating 1 ton of water, while the dual effect model has energy-saving advantages for concentrating fermentation broth in aqueous solutions, significantly reducing production energy costs.

  3. Strong adaptability: Optimized design for the high viscosity and easy foaming characteristics of fermentation broth, using anti foaming structure and efficient fabric system to effectively solve problems such as material sticking, entrainment, and blockage; It can adapt to fermentation broth raw materials of different concentrations and viscosities, with no limitation on concentration density (as long as the material has fluidity), meeting diverse production needs.

  4. Excellent concentration efficiency: The vacuum environment accelerates water evaporation, combined with an efficient heat exchange system (with a heat exchange area of 15-300m ² optional), resulting in a short concentration cycle and large processing capacity. The single effect evaporation capacity of a single device can reach 1000-5000L/h, and the double effect evaporation capacity can reach 1000-5000L/h, meeting the needs of large-scale production.

  5. Safety and environmental compliance: The equipment has passed ISO quality management, environmental management, occupational health and safety management system certification, and CE certification. The fully enclosed system design realizes organized recycling of gas, liquid, and solid phases, with no waste gas or liquid leakage, in compliance with GMP standards and environmental requirements; The parts in contact with the material are made of food grade and pharmaceutical grade materials such as 304/316L stainless steel. Ultra austenitic stainless steel or duplex steel can be selected according to the needs to ensure that the material is free of precipitation and contamination.

  6. Convenient operation and maintenance: Adopting a PLC fully automatic control system, precise control of key parameters such as vacuum degree, temperature, and feeding speed is achieved. After one click start, there is no need for manual intervention throughout the process, with strong stability and low failure rate; The equipment has fewer vulnerable parts and is equipped with an online automatic cleaning system, making maintenance convenient and efficient, significantly reducing labor intensity.

  7. Stable and reliable quality: Based on Shanghai Minjie's 25 years of experience in vacuum equipment research and development, the equipment is manufactured using processing equipment such as automatic laser welding machines and CNC machining centers. The product quality is stable, and the success rate of customer testing and equipment operation reaches 100%. We have established long-term cooperation with quantum high-tech enterprises and have high market recognition.