Euro American NS-90Z Plus Nano Particle Size and Potential Analyzer

Product Introduction

NS-90ZThe Plus Nano Particle Size and Potential Analyzer was successfully introduced and absorbed by Zhuhai Ouaike Instrument Co., Ltd. using Marvin Panaco（Malvern Panalytical）After the characterization technology of nanoparticles, in the previous generationNS-90ZA new product that further optimizes optical and electronic measurement technology and analytical performance based on.NS-90ZPlus has more powerful particle size and potential analysis capabilities, which can meet the testing needs of particle size and Zeta potential for a wide range of nanomaterials, formulation development, and production users.

NS-90ZThe Plus nanoparticle size and potential analyzer uses dynamic light scattering technology to measure particle size and particle size, and electrophoretic light scattering technology to determine particle sizeZetaPotential and potential distribution, combined with static light scattering technology, are used to determine the molecular weight of proteins and polymers. The NS-90Z Plus integrates the M3-PALS fast slow field mixed phase detection and analysis technology under the constant current mode of Malvern Panaco, improving the potential analysis performance of the instrumentUpgraded compatibilityvarious, multiple, diverse, a variety ofThe sample pool (optional) function has been significantly improved in analyzing sample concentration and particle size range.

At the same time, the instrument widely adopts high-quality optoelectronic components from the global supply chain and Scrum software iterative upgrade development mode, making it have high quality and the ability to upgrade management and reporting functions according to changes in user needs. High quality hardware such as imported avalanche photodiode (APD) detectors, He Ne gas laser light sources, and high-performance correlators, coupled with precise internal temperature control devices, sealed fiber optic path design, and advanced software algorithms, jointly ensure high reproducibility, accuracy, and sensitivity of data. NS-90Z Plus supports SOP standardization operations and has audit, permission management, and electronic signature functions that are compatible with CFDA GMP's "Computerized Systems and Validation" requirements. It also has intelligent feedback and optimization suggestions for test data quality, making it convenient for users to use.

Working Principle:

NS-90Z Plus Nano Particle Size and Potential AnalyzerThree testing techniques are integrated into a compact instrument:

Dynamic light scattering technology

NS-90Z PlusNano particle size and potential analyzer using classic90 ° angledynamic light scattering(Dynamic Light Scattering/DLS)Technology is used to measure particles and their particle size. This technology uses a photodetector to measure the scattered light intensity fluctuation signals generated by Brownian motion of particles in the sample, and calculates the correlation function through a digital correlator(Correlation Function) to analyze the diffusion rate of particlesAnd then with Stokes-Einstein(Stokes-Einstein)Calculate the particle size and distribution using the equation. The particle size measured by this technology is the hydrodynamic equivalent diameter, which is calculated by calculating the equivalent diameter of a hard sphere with the same diffusion rate. Dynamic light scattering method, also known as photon correlation spectroscopy(Photon Correlation Spectroscopy/PCS).

NS-90Z Plus dynamic light scattering optical path diagram

Electrophoretic light scattering technology

NS-90Z Plus uses electrophoretic light scattering（Electrophoretic Light Scattering/Measurement of Zeta potential of particle slip layer using ELS technology. Particles undergo electrophoretic motion under the influence of an artificially applied electric field, and their electrophoretic motion rate is directly related to the Zeta potential, expressed by the Henry equation.NS-90Z PlusPhase Analysis of Fast Slow Field Hybrid Laser Doppler in Constant Current Mode（Mixed mode measurement, phase analysis light scattering/M3-PALS)， Successfully resolved the impact of capillary electroosmosis on testing, and simultaneously obtained the average Zeta potential and potential distribution curve during a single testing process. Electrophoretic light scattering technology can measure particles up to a maximum size of 100μmZeta potential of the left and right samples (depending on sample properties and preparation).

Conceptual diagram of Zeta potential

NS-90Z Plus electrophoretic light scattering optical path diagram

Static light scattering technology

NS-90Z PlusNano particle size and potential analyzerUsing Static Light Scattering (SLS) technology for non-invasive purposesformulaCharacterize the molar mass, i.e. molecular weight, of protein monomers, aggregates, or polymers in solutions and colloids. inIn the description of molecular weight calculation using the Debye method, the scattered light intensity generated by particles is proportional to the square of the weight average molecular weight and the particle concentration. Measure a sample with a concentration gradient using the Debye methodStatic scattered light intensityIt can calculate the molecular weight of proteins and polymers.Different from dynamic light scattering technologyofStatic light scattering technology measures the average intensity of scattered light over a period of time.The molecular weight unit is Da(Dalton)Or g/mol.

NS-90Z PlusStatic light scattering Debye diagram method for analyzing the molecular weight of nanoparticles

Purpose:

NS-90Z Plus Nano Particle Size and Potential Analyzerisahighcost-effectivenessCharacterization instrument for nanoparticle size and Zeta potential of nano and micro particlesSuitable for material analysis with high sensitivity requirements for particle size and potential distribution characterization, as well as for materials that require coordination withUse90°scatteringAngular particle size testApplications with the same system results.This instrumentsuituseRegarding molecules and proteinsPolymerColloid, lotion、Testing and analysis of samples such as suspensions and various complex formulation systems.

Typical applications:

• Colloid and lotion characterization

• Formulation and process development of drug dispersion systems, lotion and vaccines

• Development of liposomes and vesicles

•Evaluation of proteins and their aggregates

Characterization of particle size, dispersion, and stability of electrode slurry and additives

Prediction of dispersion performance of coating materials

Modification of high conductivity sols such as nano gold

• Improvement of ink, toner, dye, and pigment properties

Optimize the use of coagulants in water treatment

•Stability evaluation of colloid, lotion and size

• Determine processing parameters such as mixing and homogenization for multiple complex formulations

Performance characteristics:

Advanced high signal-to-noise ratio optical design

NS-90Z Plus Nano Particle Size and Potential AnalyzerIntegrated in a compact instrumentElectrophoretic light scatteringDynamic light scattering and static light scatteringthreeOptical principle technology. Through optimized optical design, fiber optic transmission design, high-performance light sources, signal acquisition and processing hardware, the ability to recognize scattered light signals has been improved and stray light interference has been reduced, ensuring high accuracy, sensitivity and reproducibility of instrument test results and expanding the suitable sample testing range.

Schematic diagram of dynamic light scattering particle size measurement

Easy to use, maintenance free system design

NS-90ZPlusAdopting a sealed optical path design to prevent pollution, the host does not require maintenance for daily use. Adopting a replaceable and versatile colorimetric dish sample pool, it is easy to use and can simultaneously prepare multiple samples for sequential detection, resulting in higher efficiency. The sample pool can also be cleaned and reused without the need for complex instrument or detection device maintenance.

Colorimetric dish sample pool

A gas laser light source with high optical performance, stability, and long lifespan

Adopting imported highly stable He Ne gas laser to ensure data reproducibility, with a wavelength of 632.8nm， The power is 4mW. The beam divergence angle, monochromaticity, temperature and voltage fluctuation stability, and coherence of He Ne gas lasers are far superior to those of semiconductor solid-state lasers. NS-90ZThe gas laser tube used by PlusUsing hard packaging technology to ensure that the inert working substance of helium neon gas in the laser tube is not lost for life, and the lifespan of the laser tube reachesover 10 yearsAnd its optical quality remains almost unchanged throughout its lifecycle, ensuring that the test data is always reliable and does not require user calibration. Due to the significantly better coherence performance of He Ne gas lasers compared to semiconductor solid-state lasers, scattering light signals that meet measurement requirements can be generated with lower power, while also having lower stray light noise, resulting in higher sensitivity for sample analysis. instrumentThe laser intensity can be adaptively adjusted through an attenuator within a dynamic range of 33000:1.

The report can customize multiple parameter outputs

NS-90ZPlus has complete nano particle size and Zeta potential analysis capabilities. It can output parameters such as Z-average diameter, polydispersity index PI, peak particle size and content of each particle size distribution peak, and can also outputVolume and quantity distribution (using)Full range Mie Theory calculationsCan output parameters such as Zeta potential and potential distribution.

Customizable report

High performance detector

Using avalanche photodiode (APD) detectors with high quantum efficiency (QE), QE≥80%@632.8nm，The sensitivity is much higher than that of photomultiplier tubes (PMT) and the noise is lowerHigh cost high-quality APD componentsEnsured the testing performance of the instrument.

APD Performance Chart

Research level digital correlators

Using high-speed digital correlators,more than4000通道， 1011Dynamic linear range,The shortest sampling time interval can be as low as 25ns, combined with advanced related algorithms, the shortest sub measurement time can be shortened to1.68s.

Typical correlation curve diagram

Accurate internal temperature control system

The independent Peltier cycle temperature control device can operate at 0-120Within the temperature range of ℃, it can be set arbitrarily, with fast heating and cooling speed and precise controlThe highest possibleReaching 0.1 ℃ ensures high reproducibility of test results.

M3-PALS Fast Slow Field Hybrid Phase Detection Technology in Constant Current Mode

The NS-90Z Plus, combined with Marvin Panaco's M3-PALS technology, not only eliminates the influence of electroosmosis, but also enables higher conductivity sample testing in the newly upgraded constant current mode. Constant current modeThe formula can effectively alleviate the influence of electrode polarization, and together with the switchable high-frequency and low-frequency mixed analysis mode, it makes the results more reproducible, accurate, and can obtain information on potential distribution. Compared to the previous generation product, the NS-90Z Plus can meet the Zeta potential and electrophoretic mobility testing of samples with higher conductivity, while also increasing the frequency of use of the potential sample cell.

Zeta potential distribution, phase, frequency shift, voltage and current maps for mixed phase detection of fast and slow fields

Upgraded expert guidance function improves testing level

NS-90ZPlusAfter testing, intelligent expert guidance will be automatically generated under the data quality guide module, providing feasible suggestions on how to further optimize testing or sample processing. This technology can assist users in quickly interpreting more accurate particle size, Zeta potential, and potential distribution results simultaneouslyIt is conducive to reducing errors in test data and timely detecting and improving changes in test quality caused by changes in methods or environments.

Data Quality Guidelines

【Has audit, permission management, and electronic signature functions that comply with CFDA GMP's requirements for computerized systems and validation】

Schematic diagram of user permission configuration and management functions

Diagram of Audit Tracking Function

Feature rich software optimizes user experience

Provide standardized operating procedures (SOP) to simplify routine measurements; Automatically configure the optimal hardware and algorithm settings for various samples, or manually set them; Easy to operate, no need for alignment, calibration or additional maintenanceIntelligent, capable of automatically assessing the quality of data reports and providing optimization suggestions.

1. Using advanced SCRUM software iterative development mode and innovative interface design based on current mainstream software development technology, the operation is simple and easy to use, and the software can be continuously upgraded to match industry applications and regulatory changes.

2. Fully automatic hardware setup and measurement: with simple trainingJust set it upInstruments, including sample pool location, data recording, analysis, and result display.

Schematic diagram of the setting interface (partial) and analysis model selection for potential testing

3. Support SOPStandardized operating procedures，Avoiding inconsistencies in testing operations and parameter settingsThereby improving the datareproducibility.

SOP Standardized Operating Procedures

4. Systematic evaluation of intelligent measurement dataInstrument analysis software can be used based on testing conditions and resultsAutomatically and intelligently assess the quality of data reports and provide improvement suggestions for tests with poor quality. containQuality evaluation of test reports, causes of problemsHow to use this dataHow to improve these dataWait.

5. Printing or displaying reports on screen is easy to use; including report designerSimply select the desired result chart at the designated location to meet different needs定制Different reports.

Custom report function demonstration

6. Sample data and results are stored in measurement files for easy comparison of data.

7. Data analysis:The data is presented in the form of graphics or tables and can be exported with just one click; Multiple analysis modes are available for selection, suitable for testing various samples including monodisperse samples and wide distribution samples; It has multiple functions for data classification, grouping, sorting, filtering, statistics, and trend analysis.

Z-average particle size trend chart

8. A database of medium viscosity with * and the ability to automatically calculate the viscosity of common buffer systems based on a given temperature.

Medium viscosity database

Typical test results:

1. NS-90Z Plus Good Reproducibility -60nm Label Latex Microsphere Standard (Thermal, nominal value: 62 ± 3nm)

2. NS-90Z Plus improves particle size upper limit analysis performance -10 μ mlabelTesting of standard samples*

*Use a microcapillary sample cell for particle size analysis.

3. NS-90Z Plus resolution -60nm, 200nm dual standard mixed sample

4. Measurement of potential and potential distribution of NS-90Z Plus - ZTS1240 potential standard sample

Technical parameters:

【 Grain 】path】

1. measurement range^*：0.3nm - 10μm (Depends on the sample)

2. Measurement principle: dynamic light scattering method(DLS)

3. Repetitive error:≤1% (NISTTraceable latexreference material)

4. Minimum sample volume^*：20µL

5. Minimum sample concentration:≤1mg/mL (Depends on the sample)

6. Maximum sample concentration:40% w/v (Depends on the sample)

7. Minimum testing time:1.68s

Molecular weight

8. Molecular weight measurement range: 980 - 2×10⁷Da (Depends on the sample)Static light scatteringDebye Law

342 -2×10⁷Da (Depends on the sample)， dynamic light scatteringCalculation

【ZetaPotential

9. ZetaPotential range: No practical limitations

10. Upper limit of particle size applicable for testing: not less than100μm (Depends on the sample)

11. Maximum electrophoresis speedRate:>+20μ.cm/V.s /＜-20μ.cm/V.s

12. Measurement principle: electrophoretic light scattering methodELS

13. Maximum sample concentration:40% w/v (Depends on the sample)

14. Minimum samplevolume：20μL

15. Highest sample conductivity:260mS/cm

16. Detection Technology: Phase Analysis of Fast Slow Field Mixed Mode(M3-PALS), constant current mode

【system】

17. laserLight source: high stabilityHe-NeGas laser, wavelength632.8nm, Power4mW.

18. Whole machine laser safety:Iclass

19. Detection angle: 90°，13°

20. Detector: Avalanche photodiode(APD)Detector,QE>80%@632.8nm

21. Correlators:sampling time 25ns -8000sMore than4000通道，10¹¹Dynamic linear range

22. Condensation control: dry nitrogen orairpurging (External gas source required)

23. Temperature control range:0 - 120℃

24. Maximum precision of temperature control:± 0.1 ℃

25. Compatible withCFDA GMPAudit, permission management, and electronic signature functions for computerized systems and validation

[Weight and Size]

26. Host size:322×565×245 mm (W×D×H)

27. Net weight of the host:19kg

28. Power requirements：AC100 -240V, 50 -60Hz，4.0A

29. Power: maximum value100W, typical value45W

30. Recommended computer configuration:Intel Core i5 2.5GhzAnd above,4GBMemory,250GHard drive, display resolution1440×900 32bitand above

31. Computer interface:USB 2.0or higher

32. Recommended operating system:Windows 10orWindows 11Professional Edition

33. Environmental requirements: Temperature10 - 35℃，Humidity:35 - 80%， No condensation

*Optional microcapillary sample pool with extended particle size analysis upper limit up to15The minimum sample size is only required for a sample size of μ m3μL.

**Although we have made every effort to ensure the accuracy and completeness of the information in this material, we reserve the right to change any content in this material at any time.