Ultra fine pulverizer, economical and applicable ultra fine pulverizer

1. The crushing process is fully enclosed and non graded (preservation of drug components)

As is well known, traditional Chinese medicine has complex ingredients, including alkaloids, glycosides, volatile oils, organic acids, flavonoids, etc. These active ingredients often exist in different parts of the drug. For example, ginsenosides have a higher content in the cortex than in the core material, while the starch content in the core material is high. When crushing, the core material is easier to crush than the cortex. If selective crushing is used (i.e. less grinding and more screening), the easily crushed substances will first become micro powders, while the difficult to crush substances will be thrown away as slag. At the same time, the volatile components in the drug will also be carried away with a large amount of gas during pneumatic classification. This is why air flow crushing significantly reduces the content of saponins and volatile components when crushing ginseng and agarwood to a certain fineness. The rotor crusher has high crushing temperature, extremely low micro crushing efficiency, and large dust, which can be ignored.

At the beginning of its design, the Sanqing micro powder machine took into account the diversity and complexity of traditional Chinese medicine ingredients. It adopted a multi grinding without screening method in the crushing process, utilizing the third-generation vibration grinding theory (selective crushing of large particles), and operated in a fully enclosed manner without grading to prevent component segregation and loss.

The same applies to compound traditional Chinese medicine, but with the addition of varying degrees of pulverizability for different herbs, selective pulverization results in differences in the ratio of different herbs in the final product. The decrease in efficacy caused by component segregation and loss will vary depending on the drug and active ingredient.

Unit and integrated operations can minimize intermediate links and significantly reduce drug contamination; Fully enclosed operations can minimize drug loss and avoid contamination to the greatest extent possible; Non graded assignments maintain all components of prescription medication without loss of active ingredients. This not only conforms to the development trend of pharmaceuticals but also meets the requirements of prescription drugs.

2. Effective compression and crushing method (increased bioavailability brought by precision compounding)

Both airflow pulverization and rotor pulverization methods use unidirectional force application. The magnitude of the pulverization force is not only related to the magnitude and speed of the applied force, but also to the mass (weight) of the pulverization receptor. If the mass of the pulverized material is small, the pulverization effect is poor. And due to its unidirectional impact force, it will cause yielding during crushing for tough and elastic materials, resulting in ineffective crushing. Due to the aforementioned characteristics of both animal and plant medicines in traditional Chinese medicine, the crushing efficiency is low. But for mineral medicines, they are generally brittle and of high quality, and the efficiency of air flow crushing is also relatively high.

Both the Sanqing micro powder machine and the ball mill belong to compression crushing, but the impact acceleration of the Sanqing micro powder machine is more than 6 times the acceleration of gravity, while that of the ball mill is 1 time.

Working principle of Sanqing ultrafine crusher:

Under the action of external excitation force, the grinding medium undergoes a throwing motion that sometimes disperses and sometimes aggregates. The grinding medium itself rotates in the same direction, while the grinding medium group revolves. The inner and outer grinding media constantly exchange positions, and the two grinding media constantly collide, squeeze, and shear the material, causing it to be crushed and sheared. The particles are constantly broken from large to small. During the crushing process, larger particles are subjected to force first and are crushed first.

According to the working principle, particles composed of plant cell groups, whether composed of large cells or small cell groups, have equal opportunities for compression and impact as long as their overall size is comparable. In the process of crushing medicinal herbs, whether it is a large cell group or a small cell group, as long as their overall size is equivalent, the probability of being crushed is the same.

Solved various problems in crushing operations:

Strong fibrosis (Ganoderma lucidum, Astragalus membranaceus, etc.), high sugar and high viscosity (Goji berries, Rehmannia glutinosa, etc.)

Resin based materials (frankincense, myrrh, etc.) with strong toughness (antelope horn, hawksbill turtle, etc.)

Animals (scorpions, centipedes, etc.) and oils (almonds, schisandra, etc.)）

The company is a high-tech enterprise specializing in the production of ultra micro pulverizers (cell wall breaking machines) and micro (nano) Rice noodles technology, process, equipment and technical services. The company has combined powder technology with traditional Chinese medicine to study the characteristics and particle size of over 2000 types of Chinese medicinal materials. Through tens of thousands of wall breaking (membrane breaking) micro crushing experiments, it has accumulated a wealth of successful practical experience. The ultrafine pulverizer produced by the company has the characteristics of high pulverization efficiency, high wall breaking rate, low pulverization temperature, and fully enclosed operation; It belongs to the common technology for the preparation of micro (nano) Rice noodles and micro (nano) meter practical technical products; The particle size of the powder can reach 1-0.1 μ m, and the cell wall (membrane) breaking rate is over 98%; The application scope involves industries such as pharmaceuticals (including veterinary drugs and pesticides), (health) food, cosmetics, chemical building materials, metallurgical energy, electronic environmental protection, etc; And it has received unanimous praise and acclaim from users.

Equipment modelTechnical Parameterintroduce

Project model	SQW—6 J	SQW—6A	SQW—6DI
Nominal volume	6.3 L
Loading quantity	1.2 L/time
Main motor power	1.1KW
Low temperature configuration	water circulation		refrigeration machine
supply voltage	3-phase 380V
Operation mode	Manual flip type
enclosures	Low noise stainless steel soundproof cover
Dimensions (mm)	1030×740×1500
Weight (Kg)	420	480
Delivery time (working days)	twenty

AHigh crushing efficiency:Suitable for any fibrous, high toughness, high hardness, and moisture content less than 6% material, with low energy consumption and low temperature, avoiding high-temperature oxidation, deterioration, and loss and segregation of active ingredients. Crushing processFully enclosed and dust-freeOverflow, fully improving the working environment.

B、Strong crushing ability： Crush without residueSuitable for both dry and wet crushing, water, alcohol, or other solvents can be added during wet crushing.

Suitable for crushing requirements with a central particle size of 150 mesh to 10000 mesh (1.3 μ m), and can reach 1 to 0.1 μ m when using special processes. Materials that require breaking the cell wall of spores such as pollen and Ganoderma spore powderThe wall breaking rate is higher than 95%.

C、GMP design:Designed according to GMP standards and made of stainless steel that meets the requirements of pharmaceutical and food standards,The contact area with the material isPolished stainless steel，The internal corners and arcs are excessive, and the fully enclosed operation has no dust pollution or material loss.

DEasy to operate:Compact and reasonable structure with small footprint, no need for air compressors, conveying pipelines, dust removal and collection devices, and can be put into operation by connecting water and electricity. Easy to assemble, disassemble, and replace materials; Can be cleaned and disinfected with water, starch, alcohol, etc; Equipped with a composite soundproof cover, the production noise is low.

EEasy to operate:Low labor intensity, easy to operate, convenient for disassembly, cleaning, and daily maintenance.

FComplete range of models:There are both large and medium-sized equipment suitable for industrial production, as well as small equipment suitable for small-scale production or scientific research experiments.

GApplication scope:Suitable for animals (plants), mineral medicinal materials, and (health) food raw materials with different species characteristics and significant differences, such as materials with toughness, brittleness, high (low) hardness, high fiber content, high oil content, or high sugar content.

HAppearance:Stainless steel fully enclosed, made of matte stainless steel plate.

I、Precision coating：Can produce particles of two or more materialsPrecision compounding and coatingHigh solid content, strong homogenization, and super emulsification operations.

JLow temperature quality crushing, crushing fresh Chinese herbs and animal fresh tissues.

KTemperature controllable：The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. When low-temperature crushing is required, a refrigeration system should be configuredThe lowest temperature can reach -35 ℃.

Other process application methods:

1、 Application in the cosmetics industry: After breaking through the cell wall through three clear micro pulverization, the super effect time is shorter, the absorption is more complete, the efficacy is more comprehensive, and the effect is more obvious. Some fresh medicines can also be crushed and directly made into cosmetics.

2、 Application in the animal medicine industry: Sanqing micro powder technology is an effective means of implementing green animal medicine. (Traditional Chinese medicine) animal medicine can effectively improve efficacy, reduce costs, solve drug residues, and improve safety after cell wall breaking. Chinese medicine micro powder quickly disperses and suspends in water, and is supplied to livestock for normal drinking through an automatic water dispenser, effectively solving the problems of drug precipitation and uneven dosage that lead to reduced efficacy.

3、 Application of precious fine materials

4、 Precision mixing (achieving composite and precision coating with uniformity better than ± 1 ‰)

5、 The impact on molding (including coating)

a) For tablets and capsules, improve dissolution rate and enhance bioavailability; Improve appearance and uniformity of particle content; Reduced fiber elasticity makes it easier to pelletize and compress; Increase the specific gravity of the capsule to increase its filling capacity;

b) For soft capsules, improve the mixing uniformity between the main drug and the matrix, and reduce sedimentation; Due to the increase in the particle size of the main drug, the amount of matrix used can be correspondingly reduced, thereby lowering costs; Equal volume particles, thixotropy, particle size distribution, compression crushing
C) For ointment, gel and other external preparations, improve the mixing uniformity of the main drug and the matrix; Improve the delicacy of appearance; Reduced particle size facilitates transdermal absorption and improves therapeutic efficacy;