Cell wall breaking machine, traditional Chinese medicine cell wall breaking machine

Shandong Sanqing specializes in manufacturing ultrafine crushers and low-temperature crushers, which are reliable and solve various problems in crushing operations: strong fibrous (Ganoderma lucidum, Astragalus membranaceus, etc.), high sugar and high viscosity (Goji berries, Rehmannia glutinosa, etc.), resin (frankincense, myrrh, etc.), toughness (Antelope horn, hawksbill turtle, etc.), animal (scorpion, centipede, etc.), oil (almond, Schisandra chinensis, etc.)

Modern ultrafine grinding technology for traditional Chinese medicine
Equipment and processes for low-temperature pulverizer, ultrafine pulverizer, xanthan gum specific pulverizer, and traditional Chinese medicine cell level micro pulverizer
Product high-end configuration: The system adopts touch screen control, which has a more perfect appearance and is more convenient to use.

Our company isSpecializing in the production of ultrafine pulverizers (cell wall breaking machines) and engaged in micro(Na) High tech enterprises engaged in Rice noodles technology, process, equipment and technical servicesThe company has combined powder technology with traditional Chinese medicine to study the characteristics and particle size of over 2000 types of Chinese medicinal materials. Through tens of thousands of wall breaking (membrane breaking) micro crushing experiments, it has accumulated a wealth of successful practical experience. The ultrafine pulverizer produced by the company has the characteristics of high pulverization efficiency, high wall breaking rate, low pulverization temperature, and fully enclosed operation; It belongs to the common technology for the preparation of micro (nano) Rice noodles and micro (nano) meter practical technical products; The particle size of the powder can reach 1-0.1 μ m, and the cell wall (membrane) breaking rate is over 98%; The application scope involves industries such as pharmaceuticals (including veterinary drugs and pesticides), (health) food, cosmetics, chemical building materials, metallurgical energy, electronic environmental protection, etc; And it has received unanimous praise and acclaim from users.

Application of Sanqing Micro powder Machine in Traditional Chinese Medicine Pharmaceutical Engineering:
Combining theory with practiceon the basis ofTo achieve a complete solution for users with practical purposes.

For several years, the company's experimental technicians have continuously conducted tens of thousands of crushing experiments for users in various traditional Chinese medicine industries across the country, including pharmaceuticals, scientific research, universities, enterprises, hospitals, etc. Nearly a thousand varieties of traditional Chinese medicine and hundreds of traditional Chinese medicine formulas have been developed, forming a complete set of cell level micro crushing process conditions for traditional Chinese medicine. Due to the diverse varieties of traditional Chinese medicine cell level micro pulverization, the subsequent units of micro pulverization are different from conventional ones. In the work, personalized analysis of raw material characteristics and user requirements is emphasized, and corresponding systems have been formed for raw material processing, subsequent preparations, packaging, storage and transportation, and other related issues.

The company has made countless modifications to the appearance, crushing effect, material adaptability, operability, maintainability, cleaning performance, noise, long-term continuous operation reliability of equipment, human factors affecting operators, regional differences, site differences, etc. of the equipment. Lay a solid foundation for the stability of product quality.

The company provides users with a complete solution that includes standard cleaning SOP, standard maintenance SOP, and standard operation SOP. It has assisted several enterprises in completing GMP validation for traditional Chinese medicine micro crushing workshops.

Technical characteristics of the Sanqing micro powder machine:
The three major technical characteristics of the Sanqing micro powder machine in the traditional Chinese medicine industry are different from other crushing methods:

The crushing process is fully enclosed and non graded (preservation of drug components)

Effective compression and crushing method (increased bioavailability brought by precision compounding)

Unit operations before and after the process, quality control and GMP, other (standardization of equipment)

1The crushing process is fully enclosed and non graded (preservation of drug components):

As is well known, traditional Chinese medicine has complex ingredients, including alkaloids, glycosides, volatile oils, organic acids, flavonoids, etc. These active ingredients often exist in different parts of the drug. For example, ginsenosides have a higher content in the cortex than in the core material, while the starch content in the core material is high. When crushing, the core material is easier to crush than the cortex. If selective crushing is used (i.e. less grinding and more screening), the easily crushed substances will first become micro powders, while the difficult to crush substances will be thrown away as slag. At the same time, the volatile components in the drug will also be carried away with a large amount of gas during pneumatic classification. This is why air flow crushing significantly reduces the content of saponins and volatile components when crushing ginseng and agarwood to a certain fineness. The rotor crusher has high crushing temperature, extremely low micro crushing efficiency, and large dust, which can be ignored.

At the beginning of its design, the Sanqing micro powder machine took into account the diversity and complexity of traditional Chinese medicine ingredients. It adopted a multi grinding without screening method in the crushing process, utilizing the third-generation vibration grinding theory (selective crushing of large particles), and operated in a fully enclosed manner without grading to prevent component segregation and loss.

The same applies to compound traditional Chinese medicine, but with the addition of varying degrees of pulverizability for different herbs, selective pulverization results in differences in the ratio of different herbs in the final product. The decrease in efficacy caused by component segregation and loss will vary depending on the drug and active ingredient.

Unit and integrated operations can minimize intermediate links and significantly reduce drug contamination; Fully enclosed operations can minimize drug loss and avoid contamination to the greatest extent possible; Non graded assignments maintain all components of prescription medication without loss of active ingredients. This not only conforms to the development trend of pharmaceuticals but also meets the requirements of prescription drugs.

2Effective compression and crushing method (increased bioavailability brought by precision compounding)

Both airflow pulverization and rotor pulverization methods use unidirectional force application. The magnitude of the pulverization force is not only related to the magnitude and speed of the applied force, but also to the mass (weight) of the pulverization receptor. If the mass of the pulverized material is small, the pulverization effect is poor. And due to its unidirectional impact force, it will cause yielding during crushing for tough and elastic materials, resulting in ineffective crushing. Due to the aforementioned characteristics of both animal and plant medicines in traditional Chinese medicine, the crushing efficiency is low. But for mineral medicines, they are generally brittle and of high quality, and the efficiency of air flow crushing is also relatively high.

Both the Sanqing micro powder machine and the ball mill belong to compression crushing, but the impact acceleration of the Sanqing micro powder machine is more than 6 times the acceleration of gravity, while that of the ball mill is 1 time.

Example of the working efficiency of the Sanqing micro powder machine

Raw material name	crusher	Raw material particle size	Product granularity	Crushing time	output
cinnabar	Three Clean Micro Powder Machine Test Model	-25mm	3μm	5 minutes	24Kg/h
	Ball mill 400 × 400 ×4 cylinders		-140 mesh 95%	96 hours	1.15 Kg/h
Artificial bezoar	Sanqing micro powder machine production type	-10mm	-300 mesh 95%	continuous type	43 Kg/h
	Ball mill 400 × 400 ×4 cylinders		-100 mesh 80%	24 hours	0.6 Kg/h

Due to the force mode of high acceleration impact+shear in this compression crushing method, the material is compressed, torn and crushed under the action of bidirectional composite force. The magnitude of this crushing force is not affected by the material mass, and it is also subjected to large force for materials with small mass. The results of the dissolution test of Ganoderma lucidum polysaccharides after micro crushing with two different force methods for the same batch of Ganoderma lucidum showed that the amount of Ganoderma lucidum polysaccharides dissolved after being crushed by the three clear micro powder machine was 40% higher than that after air flow crushing. There are also significant differences observed in electron microscopy images. This crushing force method can cause lattice damage to the material, and using non compressive crushing methods (airflow crushing, rotor crushing) will not destroy the crystal shape no matter how fine it is made. Taking theophylline grinding as an example, the fineness increases after non compression grinding, but the crystal form remains unchanged; When using a three clear micro powder machine for crushing, the original crystal form cannot be seen, and it appears as an amorphous particle composite with a much larger specific surface area than the former.

When using this method to crush fibrous materials, due to strong compression and tearing forces, it is easy to damage the tissue structure and fibers, causing the water (including crystal water), oil, volatile matter, and gas inside the tissue structure to be squeezed out, reducing the porosity inside the tissue and increasing the density of the material. Due to the substances inside the organizational structure being squeezed out and adsorbed on the surface of tissue fragments, the viscosity of particles increases. Under strong compression and tearing forces, particles are constantly kneaded and torn, and the substances adsorbed on the surface of the organizational structure migrate to each other, promoting the formation of emulsified combinations of oily and water-based components under the action of "biological surfactants" (usually biological tissues contain surface active substances such as saponins, proteins, etc.). We call it 'solid emulsification'. At the same time, with the continuous destruction and refinement of the tissue structure during the crushing process, under the action of compression, kneading, and tearing, the viscous effect of the migrating substances inside the tissue continuously forms new combinations of the refined fragments of different tissue structures, which we call "precision compounding". On the basis of this combination, the precisely compounded viscous particles will form a cohesive combination under compressive forces, which we call "particle clusters". The reason why the dissolution rate of the indicator components of Liuwei Dihuang using this method of compound grinding is higher than that of single powder grinding and conventional mixing may be due to this. At the same time, during the crushing process, the material becomes fluidized and is prone to longitudinal damage to non equiaxed particles (spherical bodies are the best equiaxed), promoting the formation of equiaxed particles.

3Unit operations before and after the process, quality control and GMP, other (standardization of equipment)

Working principle of Sanqing micro powder machine:

Under the action of external excitation force, the grinding medium undergoes a throwing motion that sometimes disperses and sometimes aggregates. The grinding medium itself rotates in the same direction, while the grinding medium group revolves. The inner and outer grinding media constantly exchange positions, and the two grinding media constantly collide, squeeze, and shear the material, causing it to be crushed and sheared. The particles are constantly broken from large to small. During the crushing process, larger particles are subjected to force first and are crushed first.

According to the working principle, particles composed of plant cell groups, whether composed of large cells or small cell groups, have equal opportunities for compression and impact as long as their overall size is comparable. In the process of crushing medicinal herbs, whether it is a large cell group or a small cell group, as long as their overall size is equivalent, the probability of being crushed is the same.
Solved various problems in crushing operations:

Strong fibrosis (Ganoderma lucidum, Astragalus membranaceus, etc.) High sugar and high viscosity (goji berries, cooked rice, etc.)

Resin based products (frankincense, myrrh, etc.) Strong resilience (antelope horn, hawksbill turtle, etc.)

Animals (scorpions, centipedes, etc.) Oils and fats (almonds, schisandra, etc.))

The excellent features and special performance of the Sanqing micro powder machine:

AHigh crushing efficiency:For any fibrous, high toughness, high hardness, and moisture content less than6% of the materials can adapt, with low energy consumption and low temperature, avoiding high-temperature oxidation, deterioration, and loss and segregation of active ingredients.Crushing processFully enclosed and dust-freeOverflow, fully improving the working environment.

B、Strong crushing ability：Crush without residueSuitable for both dry and wet crushing, water, alcohol, or other solvents can be added during wet crushing.

Suitable for central particle size ofThe crushing requirement of 150 to 10000 mesh (1.3 μ m) can reach 1 to 0.1 μ m when using special processes. Materials that require breaking the cell wall of spores such as pollen and Ganoderma spore powderThe wall breaking rate is higher than 95%.

C、GMPDesignpressGMP design, made of stainless steel that meets the requirements of drug and food standards,The contact area with the material isPolished stainless steel，The internal corners and arcs are excessive, and the fully enclosed operation has no dust pollution or material loss.

DEasy to operate:Compact and reasonable structure with small footprint, no need for air compressors, conveying pipelines, dust removal and collection devices, and can be put into operation by connecting water and electricity.Easy to assemble, disassemble, and replace materials; Can be cleaned and disinfected with water, starch, alcohol, etc; Equipped with a composite soundproof cover, the production noise is low.

EEasy to operate:Low labor intensity, easy to operate, convenient for disassembly, cleaning, and daily maintenance.

FComplete range of models:There are both large and medium-sized equipment suitable for industrial production, as well as small equipment suitable for small-scale production or scientific research experiments.

GApplication scope:Suitable for animals with different variety characteristics and significant differences(Plants), mineral medicinal materials, and (health) food raw materials, such as materials with toughness, brittleness, high (low) hardness, high fiber content, high oil content, or high sugar content.

HAppearance：Stainless steel fully enclosed, made of matte stainless steel plate.

I、Precision coating：Can produce particles of two or more materialsPrecision compounding and coatingHigh solid content, strong homogenization, and super emulsification operations.

JLow temperature quality crushing, crushing fresh Chinese herbs and animal fresh tissues.

KTemperature controllable：The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. When low-temperature crushing is required, a refrigeration system should be configuredThe minimum temperature can reach -45 ℃.

Other process application methods:

1Application in the cosmetics industry: After breaking through the cell wall through three clear micro pulverization, the super effect time is shorter, the absorption is more complete, the efficacy is more comprehensive, and the effect is more obvious. Some fresh medicines can also be crushed and directly made into cosmetics.

IIApplication in the animal medicine industry: Sanqing micro powder technology is an effective means of implementing green animal medicine. (Traditional Chinese medicine) animal medicine can effectively improve efficacy, reduce costs, solve drug residues, and improve safety after cell wall breaking. Chinese medicine micro powder quickly disperses and suspends in water, and is supplied to livestock for normal drinking through an automatic water dispenser, effectively solving the problems of drug precipitation and uneven dosage that lead to reduced efficacy.

IIIApplication of precious fine materials

4Precision mixing (achieving better than ±)Composite and precision coating with a uniformity of 1 ‰)

5The impact on molding (including coating)

a) For tablets and capsules, improve dissolution rate and enhance bioavailability; Improve appearance and uniformity of particle content; Reduced fiber elasticity makes it easier to pelletize and compress; Increase the specific gravity of the capsule to increase its filling capacity;

b) For soft capsules, improve the mixing uniformity between the main drug and the matrix, and reduce sedimentation; Due to the increase in the particle size of the main drug, the amount of matrix used can be correspondingly reduced, thereby lowering costs; Equal volume particles, thixotropy, particle size distribution, compression crushing

c) For ointment, gel and other external preparations, improve the mixing uniformity of the main drug and the matrix; Improve the delicacy of appearance; Reduced particle size facilitates transdermal absorption and improves therapeutic efficacy;

Comparison Table of Performance of Different Crushing Equipment

Material adaptability	Raw material characteristics	Jet mill	Rotary crusher	ball mill	Sanqing micro powder machine
	Fiber material (silk)	must not	must not	difficult	can
	Resilient material (Ganoderma lucidum)	must not	must not	difficult	good
	Adhesive material (cooked)	must not	must not	can	good
	Brittle material (cinnabar)	good	difficult	Easy	good
Volatile loss	Volatile (Musk)	Almost total loss	Significant losses	tiny	tiny
fineness	Fibrous material (-300 mesh)	difficult	difficult	difficult	Easy
	Resilient material (-300 mesh)	difficult	difficult	difficult	Easy
	Brittle materials (-3)μm)	Easy to do	must not	can	Easy
efficiency	Fibrous material (-300 mesh)	low	low	extremely low	tall
	Resilient material (-300 mesh)	low	low	extremely low	tall
	Brittle materials (-3)μm)	tall	must not	extremely low	tall
Configuration complexity		tall	higher	low	higher
Easy to operate		difficult	Fairly difficult	Easy	Easy
Changing varieties is difficult and easy		difficult	Easy	Easy	Easy
Cleaning and maintenance		difficult	Fairly difficult	Easy	Easy
Yield adaptability		batch	A small quantity in bulk	Small quantity - bulk	A small quantity in bulk
Adaptability to dry and wet crushing		dry	dry	Dry and wet	Dry and wet
Crushing temperature		lower	higher	lower	ultra-low
equipment cost		tall	higher	low	higher
operating cost		tall	higher	tall	low
noise		larger	larger	low	low
Dust (without dust removal equipment)		larger	big	low	very low
Remaining medicinal residue		have	many	have	none
Mixing function (high-precision directional mixing)		lack	lack	can	good
Wrapping function		none	none	can	good
Sealing (moisture resistance)		Non sealed	Non sealed	enclosed	Fully enclosed
Cell wall breaking rate (spores, pollen)		low	Extremely low and difficult	Extremely low and difficult	High and easy