Brooke time-domain nuclear magnetic resonance droplet size analyzer

Using minisspec time-domain nuclear magnetic resonance analysis, quickly complete quality control, process control, and research and development of emulsion products

Droplet size distribution of water in oil or water in oil emulsions

No preparation required, no dilution required

Batch determination of opaque samples

Quantification of emulsification efficiency

Emulsion stability kinetics

Control the rheological properties of the product

Selective absorption product design

Essence controlled release, API

Optimize color and appearance

Deceleration chemical deterioration

Control microbial decay

Brooke's multifunctional desktop time-domain nuclear magnetic resonance analyzer can provide a complete package solution for rapid quality/process control and research and development in the production process of emulsion products. The user-friendly Brooke minisspec instrument can detect all signals generated by hydrogen atoms in the entire sample in just a few minutes, regardless of its color or turbidity. Then, by analyzing the nuclear magnetic resonance signal, the diffusion coefficient of molecules (oil or water) inside the droplet is calculated, and the software finally outputs the droplet size distribution, including volume and quantity fraction. This process directly measures the droplet size distribution at the molecular level, without being affected by flocculation, which is different from optical methods.

The advantages of time-domain nuclear magnetic resonance technology

There are multiple techniques available for droplet size testing of emulsions, but they all have various limitations and are therefore not suitable for analyzing multiple different emulsion systems:

Optical microscopy and imaging analysis - small sample size, time-consuming, distorted droplet shape and size.

Confocal scanning microscopy and imaging analysis - the same as optical microscopy and imaging analysis.

Small angle laser light scattering method - the dilution step will completely change the structure of many emulsions, and cannot distinguish between droplets and suspended particles, resulting in droplet clusters being treated as large droplets.

Electric sensing technology - in most cases, dilution is required and a large number of droplets need to be measured separately.

Ultrasonic technology - the signal attenuation of high solid content samples is severe.

Compared to the above techniques, the droplet size distribution measurement technology based on time-domain nuclear magnetic resonance has the following properties, making it a powerful tool for emulsion analysis:

Measurement of droplet size distribution for relatively large sample sizes

The color or transparency of the sample does not affect the measurement

The presence of other particles will not be mistaken for droplets

No dilution steps or other pretreatment are required before the measurement

Measurement ability

Can measure the droplet size distribution of water in oil and oil in water samples

Measurement of droplet size distribution on the entire 1 cubic centimeter sample

The maximum available gradient strength of 4 Tesla/meter allows for analysis of large droplet sizes as small as 250 nanometers

Even if the same molecules exist inside and outside the droplet, droplet size distribution analysis can still be performed

The final results of droplet size distribution analysis include volume and quantity fractions, mean, and standard deviation

Measurement can be performed within the temperature range of -5 ℃ to+65 ℃ for the sample

The same instrument can be used for other analyses, such as but not limited to solid fat content, crystallization, water migration, etc

Suitable occasions

Droplet size distribution of water in oil or water in oil emulsion systems

Emulsion stability kinetics

Dynamic study on the changes in emulsion characteristics under specified heating conditions

Changes in Fat Crystallization and Droplet Size Distribution of Oil in Water Emulsions

Control the rheological properties, color/appearance of products by specifically designing droplet size distribution

Predicting and inhibiting microbial and chemical decay

Molecules exchange from inside the droplet to outside

Controlled release active ingredients (essence, drugs, etc.)

Design controllable digestibility and calorie value for food products

software

Flexible programming can be done using the minisspec ExpSpel experimental editor to set:

Nuclear magnetic resonance pulse sequence

Nuclear Magnetic Resonance Data Processing

Custom automation, etc

The MQ series system is suitable for various applications and provides widely used and mature time-domain nuclear magnetic resonance pulse sequences, as well as proprietary droplet size distribution software developed in collaboration with Unilever.

Diffusion data collected by Brook minisspec instrument

Analysis results of droplet size distribution output by Brook minisspec software

Detailed statistical information generated by Brook Minisec software (droplet size distribution based on volume and quantity)

Note: This instrument has not obtained the Medical Device Registration Certificate of the People's Republic of China and cannot be used for clinical diagnosis or treatment related purposes