Biological laboratory renovation: refers to the construction of a laboratory for conducting experiments related to biology through standardized laboratory design, equipment configuration, and the use of personal protective equipment. A biosafety laboratory that complies with relevant regulations and standards can effectively protect laboratory personnel, operating objects, and community environment.
Biological laboratory renovationExplanation:
A biosafety laboratory is a place for conducting experiments related to biology, built and constructed through standardized laboratory design, configuration of experimental equipment, and use of personal protective equipment. A biosafety laboratory that complies with relevant regulations and standards can effectively protect laboratory personnel, operating objects, and community environment.
Classification of hazard levels in biosafety laboratories
The biological laboratory is classified into four levels based on the level of danger, including the infectivity and harmfulness of pathogens, according to the biosafety level: P1, P2, P3, and P4. Hazard level P1
⊙ First level laboratories are generally applicable to microorganisms that have no pathogenic effect on healthy adults;
⊙ Secondary laboratories are suitable for microorganisms with moderate potential harm to humans and the environment;
⊙ The third level laboratory is suitable for pathogenic microorganisms or their toxins that mainly infect people with serious or even fatal diseases through the respiratory route;
⊙ A Level 4 laboratory is suitable for pathogenic microorganisms or their toxins that pose a high risk to human health, spread through aerosol routes or have unknown transmission routes, and for which there are currently no effective vaccines or treatment methods
Biological laboratory renovationRequirements for the layout of biosafety laboratories:
(1) Safety principle: Professional laboratories with strong toxicity and high infectivity should be isolated from office areas and form relatively independent areas; Pathogen microbiology laboratories should be located in areas with minimal personnel flow (newly established independent facilities)
(2) Laboratory flow direction: Transitioning from safe and low toxicity laboratories to high toxicity and high infectivity laboratories, high infectivity laboratories should be located at the end of buildings away from areas with frequent human activities.
(3) The pedestrian and logistics channels should be separated as much as possible, with separate channels for personnel and goods, and separate channels for clean and contaminated items.
(4) Laboratories of different categories and specialties should be set up independently, with reasonable zoning and layout.
(5) Laboratory room: The building has a floor height of 3.5-4.0m, an internal net height of 2.5-2.6m, a technical mezzanine of 1.2-1.5m, and a bay of 3.2-4.0m. The laboratory is designed to meet the requirements of testing work in terms of area. If the area is too large, it will not only waste but also increase the difficulty of airflow organization.
Biosafety laboratory zoning
(1) Polluted area: It is an area where hazardous biological factors are directly operated. Normal operations are carried out inside the safety cabinet, which is not easily contaminated indoors, but there is a possibility of serious contamination. A single or multiple main laboratories (safety cabinet rooms) can be set up within the contaminated area.
(2) Semi polluted area: It plays a role in assisting experiments and reducing pollution in the laboratory. Normal operation is generally not prone to experimental factor pollution, but there is a possibility of potential pollution.
(3) Clean area: There will be no contamination of test factors during normal operation, and personnel do not need special protection. The clean area mainly includes washing rooms, preparation rooms (or washing/preparation rooms), changing rooms, bathrooms, computer rooms, monitoring rooms, storage rooms, etc.
(4) The relationship between functional areas and pedestrian flow.
1) Personnel entry: Public clean area, changing room, buffer room, half contaminated area, buffer room, contaminated area.
2) Personnel exit: contaminated area, buffer room, half contaminated area, buffer room, shower room, changing room, public cleaning area.
(5) The relationship between functional areas and logistics
Entry of items: One double door transfer window in the clean area, half of the contaminated area, one double door transfer window, and one contaminated area.