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Basic properties of pharmaceutical grade arginine
NegotiableUpdate on 05/06
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Overview
The basic properties of pharmaceutical grade arginine include arginine (abbreviated as Arg or R in English, abbreviated as "jing" in Chinese), with a chemical formula of C6H14N4O2. Due to the substitution of the hydrogen atom (α H) on the carbon atom connected to the carboxyl group (- COOH) by the amino group (- NH2), it is an α - amino acid (α - amino acid), which can be represented by R-CH (NH2) - COOH.
Product Details
Basic properties of pharmaceutical grade arginine
1. Basic physical and chemical properties
chemical structureArginine belongs to the alpha group-Amino acid, structural formula:R-CH(NH₂)-COOHThe side chain contains guanidine groups（-C(NH₂)₂⁺）Endow it with strong alkalinity（pKₐ=12.48）.
physical properties：
Appearance: White diamond shaped crystals (containing two molecules of crystal water) or monoclinic plate-like crystals (anhydrous).
Melting point:223℃ (including crystal water),244℃ (anhydrous decomposition).
Boiling point:409.1℃（760 mmHg）.
Solubility: Easily soluble in water（50Reached at ℃400 g/L）Slightly soluble in ethanol, insoluble in ethanol.
optical rotation:L-Arginine specific rotation[alpha]Dfor+12.5° (aqueous solution).
2. chemical properties
Gender and isoelectric pointArginine is a zwitterionic molecule with an isoelectric point（pI）For10.76In strong acid（pH<1）Ammonium cation in China（NH₄⁺）Existence, strong alkali（pH>13）Carboxylate anion in China（COO⁻）Existence.
Reaction characteristics：
Amino reactionGenerate nitrogen gas with nitrous acid (measured for amino groups using the Van Slack method); Nucleophilic addition with formaldehyde to generate imine.
Carboxyl reactionCan be esterified (such as forming amino acid esters with alcohols) or acylated (with...)PCl₅Reaction).
color reactionGenerate a blue purple compound with hydrated indene ketone for identification.
3. Biochemical characteristics
physiological function：
Urea cycleParticipate in ammonia metabolism and convert it into urea for excretion.
Nitric oxide（NO）SynthesisGuanidine isNOPrecursors regulate vasodilation and blood pressure.
protein synthesisAs a coding amino acid (codon)CGU/CGCParticipate in translation.
stability：105℃Losing crystalline water,230℃Color change,244℃Decompose.
4. Other Features
safety: Avoid contact with skin（S24/25Safety signs).
isomer: ExistenceL-Type (physiological activity)D-Type andDL-Type, in natureL-Mainly type.
Basic properties of pharmaceutical grade arginine
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