Animal laboratory renovation

NegotiableUpdate on 01/19

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Overview

Animal laboratory renovation: The animal laboratory is designed to conduct biomedical research, safety testing, and the production of biological agents on experimental animals. Experimental animals refer to those that have been carefully cultivated in special environments, have clear genetic backgrounds, and effectively control microorganisms and parasites. Not all animals can be used as experimental animals for various scientific experiments.

Product Details

　　Animal laboratory renovationAnimal laboratory is a laboratory that conducts biomedical research, safety testing, and the production of biological agents on experimental animals. Experimental animals refer to those that have been carefully cultivated in special environments, have clear genetic backgrounds, and effectively control microorganisms and parasites. Not all animals can be used as experimental animals for various scientific experiments.

Animal laboratory environment and facilities

1. Site selection

The breeding, production, and experimental sites of experimental animals should avoid natural epidemic sources. It is advisable to choose areas with good air quality and natural environmental conditions. It is advisable to stay away from areas with serious air pollution, vibration, or noise interference, such as railways, docks, airports, transportation arteries, factories, warehouses, and yards that emit large amounts of dust and harmful gases. If it is not possible to stay away from the above area, it should be arranged on the downwind side of the local summer low frequency wind direction. The breeding, production, and experimental facilities of experimental animals should be kept at a distance of more than 50 meters from the living area.

2. Building hygiene requirements

All enclosure materials for animal breeding, production, and experimental sites should be non-toxic and non radioactive. The surface of the interior wall should be smooth and even, with rounded corners for easy cleaning and disinfection. The wall should be made of materials that are not easily detached, corrosion-resistant, non reflective, and impact resistant. The ground should be slip resistant, wear-resistant, and leak free. The ceiling should be water-resistant and corrosion-resistant.

3. Requirements for building facilities

Building doors and windows should have good sealing. The width of the corridor should not be less than 1.5m, and the width of the door should not be less than 1.0m. Animal breeding, production, and laboratory ventilation and air conditioning systems should maintain positive pressure operation, and the airflow should be reasonably organized to arrange the position of the air supply and exhaust vents, avoiding blind spots, cutting off flow, and short circuits. All types of environmental control equipment should be regularly maintained and serviced. The power load level for animal breeding, production, and laboratory should be determined according to the process requirements. Emergency power supply should be available. Indoor power distribution equipment should choose equipment that is not prone to dust accumulation and should be concealed. Electrical pipelines should be concealed, and reliable sealing measures should be taken for electrical pipelines entering the clean area from non clean areas.

Classification of environmental conditions and requirements for technical indicators

(1) Ordinary environment: This environmental facility meets the basic requirements for animal habitation and cannot control infectious factors. It is suitable for raising and teaching ordinary experimental animals. Common animals (CV) refer to general animals whose microorganisms are not subject to special control. Request to exclude pathogens of zoonotic diseases and a very small number of pathogens of highly infectious diseases in experimental animals.

12) Barrier environment: This environmental facility is suitable for breeding clean experimental animals and SPF experimental animals without specific pathogens. The environment strictly controls the entry and exit of personnel, items, and ambient air.

3) Isolation environment: This environmental facility uses sterile isolation devices to preserve sterile or non contaminated animals. The air, feed, water, bedding, and equipment inside the isolation device are all sterile. The dynamic transmission of animals and materials must go through a special transmission system, which can ensure isolation from the environment and maintain consistency in the internal environment during animal transportation. This environmental facility is suitable for breeding laboratory animals that are free of specific pathogens (SPF), germ free (GN), and sterile (GF).

　　Animal laboratory renovationRequirements for environmental technical indicators:

The environmental indicators of experimental animal breeding and production facilities should meet specific requirements.

Laboratory area setting and layout

(1) The setup of the front area includes offices, maintenance rooms, warehouses, feed rooms, and general corridors.

(2) The setting of breeding areas includes isolation and quarantine rooms, buffer rooms, breeding rooms, expanded breeding rooms, production breeding rooms, waiting rooms, clean goods storage rooms, clean corridors, and waste corridors.

(3) Animal experimental area: including buffer room, experimental feeding room, clean item storage room, clean corridor, and waste corridor.

(4) Auxiliary area: including warehouse, washroom, waste storage and processing room (equipment), closed laboratory animal carcass refrigeration storage room (equipment), mechanical equipment room, shower room, and staff lounge.

(5) Other facilities and equipment: Both barrier and isolation environments should have buffer settings at the intersection of pressure changes.

The facilities in the animal experimental area should be set up separately from the breeding system. The operation of radioactive experiments should be carried out in accordance with GB4792. Animal experiments involving highly infectious, carcinogenic, and toxic substances should be conducted in negative pressure isolation facilities or equipment with strict protection. Such facilities (equipment) must have a special transmission system to ensure isolation from the external environment during dynamic transmission, and exhaust gases and waste must be treated harmlessly. The three protection principles of "human, animal, and environment" should be reflected.

When setting up equipment in an experimental environment, its performance and indicators must be consistent with the requirements of environmental facilities. Positive and negative pressure equipment with different experimental requirements must meet the indicators of environmental facilities.

Animal laboratory biosafety classification

(1) Level 1 biosafety level: Animal facilities are suitable for breeding most reserve experimental animals that have undergone quarantine, except for primates, as well as animals specifically inoculated with Level 1 dangerous microorganisms.

(2) Level 2 Biosafety: Animal facilities are suitable for animals that have been specifically inoculated with Level 2 hazardous microorganisms and must meet all requirements of Level 1 Biosafety animal facilities. Post biohazard warning signs at doors and other suitable locations. The design of facilities must be easy to clean and manage. The door must open inward and can automatically close.

If mechanical ventilation is used, the direction of the airflow must be inward. The discharged air should be discharged outdoors and not circulated inside the building. If there are windows, they must be safe and resistant to breakage. If the window can be opened, anti arthropod netting must be installed. Work that may generate aerosols must use biosafety cabinets (Class I or II) or isolation boxes, which must be equipped with gas supply and HEPA filtered exhaust devices. Animal carcasses must be incinerated for disposal.

(3) Level 3 biosafety level: Animal facilities are suitable for animals that have been specifically inoculated with Level 3 dangerous microorganisms, or determined based on the results of a risk assessment. All systems, operations, and procedures need to be rechecked and validated annually. Must meet all requirements for animal facilities with first and second level biosafety levels. The facility must be separated from other parts of the laboratory and animal rooms by a buffer room consisting of double door entrances. Hand washing facilities must be equipped in the buffer room. Shower facilities must be equipped in the buffer room. Mechanical ventilation must be used to ensure continuous airflow through each room. Before indoor air is discharged outdoors, it must be filtered by HEPA and cannot be recycled. The design of the system must be able to prevent accidental backflow and positive pressure in the animal room. Infectious waste must undergo high-pressure sterilization before being moved to other areas. The feeding cages for animals with a risk level of infection of microorganisms must be placed in isolation or in a room equipped with ventilation system vents behind the cages. Windows must be closed, tightly sealed, and resistant to damage.