Animal Bone Density Measurement System

Bozhuo Biotechnology (Shanghai) Co., Ltd

BiodrvierTechnology Inc.

Introduction to KUBTEC

KUBTEC Corporation in the United States ismedical andlaboratoryX-ray equipment manufacturers, KUBTECProvide digital X-ray equipment for sample X-ray imaging, low-dose imaging, scientific research, forensic analysis, non-destructive testing, and X-ray irradiationInnovative tools. KUBTEC's products enable medical professionals to provide patients with excellent quality of careAt the same time, it also provides high-performance laboratory X-ray equipment to support scientific research for laboratory researchers.

lKUBTEC provides a complete set of imaging solutions for breast radiologists, breast surgeons, clinical doctors, pathologists, scientists, and laboratories worldwide. KUBTECThe MOZART The series provides the currentThe intraoperative breast sample imaging using 3D tomographic tomography tomography technology helps to maximize breast preservation, while preserving integrity to remove breast tumors, reducing the probability of reoperation after breast cancer resection by more than 50%.

lKUBTEC company isLow dose numbersThe main developer of X-ray radiography (DR) systems, KUB 250, is the first truly portable product to receive FDA approvalUsed for neonatal intensive care unitThe low-dose digital X-ray system of NICU is the highest resolution low-dose imaging system provided for newbornsSimultaneously reducing radiation dose by over 40%.

lKUBTEC's XPERT real-time sample X-ray imaging system provides clear imaging results, reduces processing time to make patients feel more comfortable, and supports bedside surgery.

lThe XPERT/PARAMETER series digital X-ray radiation system (DR) can provide the highest resolution and practical imaging system, improving the research and work efficiency of laboratories. Widely used inspecimenX-ray imaging, scientific research, forensic analysis, non-destructive testing, radiation biology and other fields.

lThe XCELL series biological irradiation instrument is widely used in large laboratories worldwide and can provide customized services to meet different research needs.

lKUBTECApprovedCertified with ISO 9001 and ISO 13485, we design and manufacture equipment that meets the radiation safety standards of major countries around the world such as the United States, Canada, and Europe. We provide system manufacturing and training support worldwide.

Preclinical product line

nDigital X-ray Sample Analysis System

1. High resolution small animal digital X-ray machine

2. Animal Bone Density and Body Composition Analysis System - SXA&DXA

3. Botany specific digital X-ray analysis system

4. 3D X-ray digital imaging system

5. X-ray pathology analysis system

nX-ray irradiation instrument

1. Desktop small sample biological X-ray irradiation instrument XCELL 50

2. Desktop biological X-ray irradiation instrument XCELL 140

3. Biological X-ray irradiator XCELL 160

4. Biological X-ray irradiator XCELL 225

5. Biological X-ray irradiator XCELL 320

6. Biological X-ray irradiator XCELL 350

7. X-ray diagnosis and treatment system

nKubtec software package

1. Kubtec DIGICO Universal Analysis Software Package

2. Kubtec specialized software package for germplasm resource research

3. Assistant imaging software package

4. Kubtec DIGIMUS animal body composition analysis software package

animal3DFault fusion imaging and bone density analysis system

In the past century, radiological technology has been the mainstay of clinical diagnostic imaging. The 21st century fault fusion method, which introduces depth information into X-ray images with almost no dose increase, replaces current projection radiology techniques.

Thanks to the application of large-sized digital X-ray detectors, digital tomography, a new type of three-dimensional X-ray imaging method, has developed rapidly. The image of fault fusion is reconstructed based on a series of projection images acquired by X-ray scanning.

2020 KUBTEC USAThe company launched clinical and preclinical trials during the same periodD Tomosynthesis（3DThe equipment series of fault fusion technology can be applied in clinical breast diagnosis and treatment, preclinical bone injury and repair research, especially in the study of subtle bone injuries, bone joint research, soft tissue and lung nodule imaging research.

3DTomography fusion imaging technology provides perspective positioning, one-time exposure, tomographic imaging, and extremely low radiation dose, which can directly obtain coronal and sagittal tomographic images (C)TGenerally, only cross-sectional images of animals can be obtained, which is particularly suitable for bone and joint trauma repair and subtle bone injury research. It can also provide a dual energy X-ray (gold standard for bone density measurement) bone density analysis and measurement module, providing a complete bone research platform tool.

KUBTEC Live Animal 3D Tomography Fusion Imaging

DXA Animal Body Composition Analysis Module

Imaging characteristics:

Fault resolution: 25um resolution@ 6cmx7.6cm@1min

Single scan, 5 imaging modes: 2D/3D/K-VIEW/optical/optical X-ray fusion image

Bone density accuracy: 0.000001g/cm2

Radiation dose: much lower than CT

Imaging time: Full body 3D imaging within 1 minute

Fault characteristics: It can quickly and directly obtain large-scale coronal and sagittal fault images

Bone density analysis module

DXA principle

Dual energy X-ray absorption measurement involves absorbing and filtering the X-rays released from the X-ray tube, dividing them into high and low energy X-rays. Based on the attenuation and absorption differences of photons with different energies passing through the human bones, the content of fat and minerals in the body is obtained through computer processing, and data such as BMC, BMD, and fat content are determined.

Advantages of DXA

DXA analysis is based on clear image quality, ensuring the accuracy and reliability of measurement results, and is the gold standard for bone density measurement. Through attenuation calibration, it ensures the accuracy of fat content.

Dual energyThe X-ray absorptiometry method is an analysis and calculation of animal bone density (BMD) and body composition (BMC, Fat, Lean), based on ultra-high resolution digital image analysis,The KUBTEC animal bone density and body composition analysis system combines real-time high-resolution digital imaging with high-quality body composition analysis softwareIt has been achievedDual energyThe X-ray absorptiometry method (WHO Gold Standard) enables high-quality in vivo X-ray imaging without the need for dissection, using the provided anesthesia interface to analyze bone density and body composition (BMC, Fat, Lean) of live experimental animals.

Generally, chemical analysis of animals takes one hour (homogenization, scraping, cleaning, weighing, drying, chemical extraction, etc.), while drying or ashing of chemical extraction takes several days. KUBTEC can analyze bones and body composition in just 30 seconds to obtain results. Since there is no need to dissect experimental animals and conduct each series of evaluations, it can reduce the consumption of 500 to 800 animals per year, saving a lot of money.

KUBTEC Animal Bone Density and Body Composition Analysis System

Features:

1. High resolution: Provides 10LP/mm high resolution and high-speed imaging, with low dose rates for animals, reducing the impact on experimentsMiniaturization.

2. High speed imaging and analysis: With simple anesthesia, experimental animal bone density and body composition (BMC, Fat, Lean) analysis data can be obtained from KUBTEC high-resolution images within 19 seconds

3. It can provide HD CCD to form high-resolution white light imaging, combined with KUBTEC Blender function, to complete color/X-ray/body composition area delineation/data analysis mutual verification function.

4. Adopting X-ray cone imaging will not cause result deviation due to different animal placement positions.

5. Multi functional imaging: can freely switch between high-resolution X-ray imaging, single energy X-ray analysis and dual energy X-ray analysis functions

6. Large field of view (FOV): Scanning range (can analyze bone density and mineral content, fat and lean meat of small animals such as mice, rats, and medium-sized animals such as dogs, cats, rabbits, and guinea pigs, with no limit on animal weight when combined with cone X-ray scanning).

7. Animal receptionlowDose irradiation: KUBTEC ensures high resolution while ensuring animal receptionlowDose, ensure that animals can be scanned multiple times over a period of time, and dynamically analyze and evaluate body composition.

8. Safe and reliable, without radiation hazards: KUBTEC's multiple chain technology and lead glass isolation device can effectively block radiation, ensuring that the surface dose of the equipment is lower than the environmental background and protecting researchers.

9. One click headless analysis function

10. Accurate and reliable data: The measurement results are accurate to 0.00001g with an error of less than 1%

11. The analysis software has powerful functions and multiple data saving formats (such as CSV/Excel format) are easy to call.

12. Sample forgetting reminder function: If the sample is left in the warehouse for a long time without operation, the system will automatically warn and remind to take out the sample in a timely manner.

13. The data results can be directly input into Solidworks to form engineering drawings for direct 3D printing output.

14. Compliant with FDA standards, FDA filing number: 0610044-00

KUBTEC Animal Bone Density and Body Composition Analysis System

Measurement indicators:

Small animal bone density value（BMD）：

·Whole body bone density valueTotal BMD

·ROI region (user)requiredBone density values ROI BMD of various parts

Body composition value of small animals（BMC,Fat,Lean）

·Whole body bone massBMC

·Local bone massROI BMC

·Bone length, area, and volume

·Fat mass

·Fat percentage content

·fat/Organizational percentage

·Muscle mass

·Muscle percentage content

3DFault fusionimagingAdvantage:

3D Fault FusionImaging is used in fracture diagnosis, fracture healing evaluation, vertebral bone assessment and fracture risk prediction, joint dislocation diagnosis, bone erosion evaluation, and more Compared with C in terms of postoperative evaluation after joint replacement surgeryT has more advantages

1. Improve the accuracy of the examination (especially the advantage of quickly locating the damaged fault plane)
2. Provide fast, low-dose, high-quality high-definition digital images (especially suitable for research on bone injury repair), with images comparable to those of CTresolution

3Through gypsum, the influence of fixed devices on imaging can be eliminated

Gypsum layerOne of the cross-sectional layers

It can be located at a specific level and eliminate the influence of prescribed substances such as gypsum on imaging

4Accurate localization research on micro fractures, irregular fractures, and joint bone injuries

3D fault fusion technology has the potential to diagnose fractures in deep and complex locationsuniqueThe sex of * has improved the detection rate and diagnostic accuracy of fracturesThe overlapping of bones in the joint area is severe, and even animal CT cannot obtain accurate images of minor or irregular fractures. 3D tomographic fusion technology has the greatest advantage

The slight damage to the greater horn of the hyoid bone cannot be detected as a whole, only a few fault planes can be seen, Kubtec Parameter-3DThe damage can be found below a specific fault plane: the left side is an X-ray imaging image, and the right side is a magnified analysis image of the plane

5The3DApplication of Fault Fusion Imaging in Joint Replacement Models—Compared to CTmore advantageous

In the evaluation of joint replacement surgery, becauseBoth CT and MRI can cause severe metal artifacts, making it difficult to evaluate the prosthesis bone and prosthesis interface using CT or MRI. Even with the help of artifact restoration and image reconstruction algorithms, the issue of artifacts still exists. Therefore, currently CT can only be used for the analysis of preoperative fractures in complex cases, but cannot be systematically applied in clinical prosthesis postoperative evaluation. Studies have shown that for joints with metal prostheses, 3D tomographic fusion can be usedImaging can reduce the hardening artifacts caused by high atomic numbers of metals, improve the image quality damaged by metal artifacts, and provide better resultsBetter quality CT images. Therefore, for the artifacts caused by the high attenuation characteristics of metals, choosing to use 3D tomographic fusion imaging is currently the best solution.

In summary, joint replacement related models adopt 3D fault fusion imaging can:

1. Confirm the growth of bone trabeculae without implants
2. Helps to display metal implant fractures
3. Helps to observe the growth of new bone in metal implants
4. The resolution of large-scale images is higher than that of CT images

6. 3DApplication of Fault Fusion Imaging in Soft Tissue Imaging

Medical fusion imaging has become the industry gold standard for breast tissue imaging, providing clear, low-dose, and fast imaging methods,Fault fusion can accurately distinguish pulmonary nodules and can be effectively applied in areas such as pneumonia and emphysema. Changing different reconstruction parameters can effectively distinguish different applications such as rib, sternum, tracheal foreign bodies, etc.

Pulmonary nodule imaging.