Aerosol generator system

PreciseInhale^®Aerosol generator systemIt is a powerful desktop aerosol generation system that enables fully controllable and precise administration of in vitro, ex vivo, and in vivo exposure modules. Typical samples include micronized dry powder, inhalation formulations such as powder sprays, aerosols, and nebulized inhalation formulations, as well as air pollution particles and nanoparticles.

PreciseInhale can not only generate well dispersed aerosols for precise drug delivery, but also characterize the aerodynamic mass median diameter (MMAD) and geometric standard deviation (GSD) of aerosols, or characterize the particle shape and size through scanning electron microscopy (SEM).

The instrument system consists ofSwedish Inhalation Sciences Sweden AB (ISAB)Production, ISAB is an innovative instrument listed company headquartered in Sweden that provides analytical instruments and research services. Its products are mainly used for aerosol and inhalation formulation research.

PreciseInhale^®Aerosol generator systemCan connectSwedenInhalation Science Company'sMultiple in vitro, ex vivo, and in vivo exposure modules (In Vitro, Ex Vivo, and In Vivo) were used for various characterizations, as shown in the following figure (product links for each module are provided below):

1. AndDissolvate^®Inhalation formulation dissolution moduleCombining to form a simulated artificial blood blood barrier, simulating the dissolution and absorption of aerosol particles in the lungs under in vitro (In Vitro) conditions.

Dissolvate^®Providing the possibility of sorting test substances and comparing the pharmacokinetic (PK) curves of candidate inhaled formulations with the original product is a true breakthrough in in in vitro and in vivo correlation (IVIVC).

2. WithXposeALI 3D (In Vitro) in vitro cell exposure moduleConnected, live cultured cells can be exposed to aerosols at the gas-liquid interface (ALI).

Uniformly deposited particles are only distributed on the surface of cells and do not deposit on the pool walls or matrix. XposeALI simulates the exposure of aerosols in an environment similar to that of the lungs (In Vitro).

3. ConnectionPreciseInhaleRodent nasal cavity exposuremoduleRats can be exposed to aerosols for in vivo (In Vivo) studies.

Accurate targeting of one animal at a timeThe exposure method significantly reduced the standard deviation of lung deposition dose. Compared to traditional "tower" exposure systems, this greatly reduces the number of animals required for inhalation studies. The precise administration of Zhuanli can ensure that the standard deviation of typical aerosol concentration is better than 10%.

4. ConnectionPreciseInhaleRodent tracheal exposure moduleRats with endotracheal intubation were exposed to aerosols for in vivo studies.

Short term inhalation of inhalable aerosols is a clinically relevant method of pulmonary administration. This module can monitor the respiratory patterns of rats and the concentration of aerosols. The standard deviation of lung deposition dose among animals is less than 10%.

5. PreciseInhaleEx vivo lung perfusion module (Ex Vivo IPL)It is specifically customized to expose inhalable aerosols generated by PreciseInhale.

IPL provides low standard deviation dose rates (typically<10%) and high-resolution data. It can study the specific effects of toxins and drugs on the lungs, as it does not involve blood circulation in the distal compartment. IPL infused in one-way mode is particularly advantageous for PK studies of inhaled drugs and toxins. In our customized IPL system, a fraction collector is used to collect the perfusion fluid throughout the entire perfusion period, which also makes it possible to monitor the perfusion fluid flow rate. The perfusion system can also be converted to a recirculation mode to facilitate the detection of accumulated substances or their metabolites in smaller perfusion volumes.