AbioBundle Multimini Series Parallel Bioreactors

AbioBundle Multimini Series Parallel BioreactorsThe working volume is 50mL, and the Aibeitai bioreactor maintains overall geometric similarity, which can truly achieve the scaling up and cultivation of laboratory scale reactors

Parallel, precise control, and highly integrated scalability

The AbioBundle Multimini series parallel bioreactor adopts an embedded+industrial computer design, with * biological process control and automation operation, modular design, process control can be parallel or independent, and can independently and parallelly control process parameters during DOE experiments; Aibeitai has developed proprietary algorithms for cell and microbial culture, with precise and stable control of process related parameters, widely applicable to various cell and microbial cultures as well as biological process development; The process parameters can be scaled up to small-scale, pilot scale, and production scale stirred bioreactors;

Each tank can operate independently or simultaneously, and up to 32 parallel bioreactor networks can be established for parallel operation, reducing process development time;
To ensure the stability of the cultivation process, Aiopt has developed a proprietary Aiopt algorithm for cell culture and a unique Gradation control for microbial fermentation to achieve precise control of process parameters;
The Aibeitai stirred bioreactor maintains geometric similarity, and the process parameters and experience can be gradually scaled up to small-scale, pilot scale, and production scale stirred bioreactors;

Application case: CHO-K1 cell culture

The modular design structure of Multimini can provide corresponding solutions according to different process requirements;
• Maintenance free stepper motor with a controllable speed range of 10-2000rpm. The stirring direction can be customized according to different vortex directions without the need to change the blade direction;
PH/DO is compatible with traditional or intelligent electrodes, and the unique Epitech algorithm can accurately control DO;
Adopting Peltier temperature control and waterless temperature control system, reducing laboratory water usage and eliminating residual cooling water;
Unique feeding design, variable speed peristaltic pump that can rotate forward and backward, and disposable feeding bottle that can quickly switch with centrifuge tube, accelerating the replacement of feeding types;
Accurate gas control, each gas is individually controlled by a mass flow controller (MFC), and the types and ranges of gases can be customized according to different processes;

Multimini parallel bioreactor can meet different needs and configurations
Glass or disposable tank, with a working volume ranging from 50-400mL;
The top interface of the tank can be customized and configured;
• Compatible with surface and deep ventilation, with deep ventilation available in large or microbubbles;
• Different types of propellers are available, such as Marine, Rushton, and eight bladed propellers;

A flexible process information system for upper computer software
• It can be easily controlled through an external display screen or through a local area network browser WebUI, and remote access can be achieved without connecting to an external network;
• Strong flexibility, can be independently or parallelly adjusted according to process requirements, can calibrate pH/DO and peristaltic pump simultaneously;
Equipped with a time/condition formula, the experimental plan can be pre-set, and each operation and alarm can be recorded. SMS or phone alarms can be optionally provided;

Parallel process development and process optimization

Parallel operations can shorten product development cycles and accelerate market launch
The embedded and industrial control computer combined with the independently developed Applisoftec data management software architecture design of the Aibeitai parallel bioreactor makes the 4-cylinder system an ideal choice for parallel control, which can be extended to 32 tanks and establish a high-throughput screening network; The Applisoftec data management software not only supports the full range of Epitech bioreactors, but also integrates third-party analytical equipment to support complex process control, data integration, and information management;

Highly integrated modular design saves laboratory space
In order to make the most of the laboratory space,AbioBundle Multimini Series Parallel BioreactorsCovering an area of 420 × 560 × 650mm, the expansion of 32 tanks only requires a 3.5m long platform space, which greatly alleviates the space shortage in the laboratory;

Mini workspace reduces research and development costs
The minimum working volume can reach 50mL, greatly reducing development costs in the early stages of product development, including the use of reagents and consumables such as culture media, feed supplements, and silicone tubes, as well as the preparation time for seed liquid and jars. Especially in some projects with high investment costs, such as stem cells such as MSC and iPSC, as well as immune cells such as NK and T, the resources required for product development are greatly reduced while managing more experiments;

Application areas: not limited to microorganisms and cell culture
The diversity of configurations allows the iBetai bioreactor to go beyond traditional microbial and cell culture, including but not limited to the following applications:;

Microbial culture
(1) Conventional recombinant protein expression in Escherichia coli and yeast;
(2) Lactic acid bacteria cultivation, such as lactic acid bacteria, brewing yeast, and bifidobacteria;
(3) Fields such as plasmid amplification, biofuel synthesis, and synthesis of novel biomaterials;
cell culture
(1) Common cell expression antibodies and vaccines such as CHO, 293, Vero, and MRC-5;
(2) Insect cells such as H5, SF9/SF21, and plant cells;
(3) MSCs, iPSCs, NK cells, and T cells are used in the CGT field;

other
(1) Chemical reactions that require temperature, stirring, and pH/conductivity, such as ADC;
(2) Enzymatic reactions that require temperature, pH, and conductivity, such as in vitro RNA transcription;

Magnification case: CHO-K1 cell culture process amplification

• Dynamic breathing light, which can indicate the working status of the system
Equipped with electrode and motor brackets as standard, keeping the laboratory space simple
• Highly integrated modular design, standard configuration can connect pH, DO, temperature and stirring, optional liquid level/foam electrode

• Variable speed peristaltic pump with forward and reverse rotation, customizable configuration, each pump comes with an independent Prime button for easy pre filling and emptying of pipelines
• Standard MFC gas control, precise flow control, customizable surface, deep bubble or deep microbubble ventilation for each gas channel

• Water free temperature control system, * Peltier temperature control, no need for experimental water
Unique feeding design, disposable feeding bottle can quickly switch with centrifuge tube, accelerating the replacement of feeding types

Main interface of external display screen

WebUI main interface

平行pH/DO校正界面

Technical parameters