Cone plate rheological analysis system

Cone plate rheological analysis system

Shilian Boyan Beijing Company provides an in vitro rheological system based on a cone plate viscometer imported from Germany, which can generate high-precision, uniform, and clear shear stress.

Place the substrate in the culture plate and cover it with the culture medium, then generate shear stress from the rotating cone above. According to your special requirements, up to 4 or even 9 cone plate units can be configured,

Can be connected to a microscope or camera, guided by software, with long-term temperature control, optional UV or impedance spectroscopy.

Possible research areas include live cells on natural or artificial substrates, such as biomaterials or immobilized proteins, synthetic microcolumns, quartz glass, or others.

5. Transparent for real-time observation and analysis:

Online observation of the investigated system,

For example, live cells

6. Long term experiment on continuous medium replacement

7. Computer controlled bioreactor:

Flexible software for easy data navigation, classification, and image acquisition for time-resolved image analysis

8. Multi channel settings:

Study on operating cells and control cells of the same passage under different shear stress levels during the same time period

Electrophysiological measurement using bar spectroscopy: the arrier_ function of the sheet forming the cell layer, for example. TER: Cross cell resistance of epithelial or endothelial cells

Electrophysiological measurement using bar spectroscopy: the carrier function of the sheet forming the cell layer, for example. TER: Cross cell resistance of epithelial or endothelial cells

9. Sealed chamber for cell culture

(such as infection, hypoxia)

Application fields

-Biomedical Sciences

1. Morphological dynamics of cells under flow

for example Cell motility, degree of orientation (alignment), and cell elongation

2. Cross cell resistance (TER) forming sheet-like cell layers under flow

For example, impedance spectroscopy can be used as an electric biosensor to examine the intercellular adhesion of endothelial cells, quantify the integrity of cell layers, and the degree of cell to cell contact.

3. The cytopathic effect of viral infection on cells

4. Measurement of wound healing scratches under flow

5. Toxicology and drug screening

Bioactive substances, such as drugs, toxins, or chemicals. Under shear stress conditions, cellular dysfunction can be detected and quantified, while their effects are usually not observable under resting conditions

2、 Biomaterials

1. Characterize biomaterials by analyzing cell movement, cell arrangement, and cell separation under mechanical shear stress

2. Measurement of protein adsorption

Dynamics through internal reflection fluorescence (e.g. related to biomaterials)

3. TIRF rheometer (H.P. Jennissen, Essen)

4. Aerodynamics and Fluid Dynamics

The Application of MPS Calibration (Micro Column Shear Stress Sensor) in Nano and Microfluidic Dynamics