In the previous marketHigh-pressure homogenizerWidely used in industries such as biotechnology, pharmaceutical preparations, dairy products, fine chemicals, and food processing, including Escherichia coli, yeast, algae wall breaking, animal cell biochemistry, enzyme engineering, genetic engineering drugs, human vaccines, animal vaccines, nanomaterials, emulsions, etc. Imported brands include APV from Germany, NIRO from Italy, ATS from Canada, AVESTIN from Canada, MFIC from the United States, etc. Domestic brands include Shanghai Donghua, Ningbo Xinzhi, Guangzhou Juneng, etc
The selection of high-pressure homogenization chamber is the core component of high-pressure homogenizer and the main factor determining the homogenization effect. The range of use and homogenization effect of high-pressure homogenization chambers with different internal structures vary.
In general, the higher the homogenization pressure, the better. Firstly, the higher the homogenization pressure, the smaller and more uniform the particle size of the homogenized material will be. This makes the equipment more efficient and can achieve the desired effect with fewer cycles; Secondly, the higher the homogenization pressure, the more types of materials can be processed. For example, some liquid emulsions can be homogenized to below 100nm at 20000psi, while some suspensions containing high-density solid particles require a pressure of at least 26000psi to be processed to the nanoscale.
However, it should also be noted that the higher the homogenization pressure, the greater the heat generation, and high temperature will affect the homogenization effect of the material. So, generally without cooling measures, 30000psi is the highest pressure for ultra-high pressure homogenization. Due to the high temperature generated by the ultra-high pressure homogenizer, the homogenization effect of over 30000 psi no longer increases with pressure. A controllable temperature type ultra-high pressure diamond interaction chamber has been developed to reduce the problem of large particle content and emulsion stability caused by high temperature.
1、 The smaller the feeding amount, the better, which can save materials. At present, the raw materials for some drugs reach several thousand yuan/gram, and users naturally hope to complete a homogenization experiment with the least amount of materials. And the experiment is a repeated process, the smaller the sample size, the more materials are wasted.
II Processing effect: Of course, users hope to produce materials that can reach the nanometer level, and at the same time, have a very uniform distribution at the nanometer level, rather than some particles being tens of nanometers while others are still micrometer level.
To solve this problem, it is recommended that users have the manufacturer provide a nanoscale filtering extruder device when purchasing a homogenizer. It is an online extruder, and offline extrusion is very troublesome.
III Cleaning and sterilization: Imported high-pressure homogenizers are very convenient for cleaning and sterilization, and it is recommended to consider online cleaning and sterilization.
4 Don't worry about the noise, safety, and number of users in China when considering a device. From the user list, it can be determined whether a device has good quality. The more users there are, the better the quality of the device.
Five Manufacturers of homogenizers usually claim that their equipment is excellent, and it is recommended that they provide a list of users and relevant achievements, papers, etc.
6、 Safety: This is of utmost importance, and no user wants to have personal safety hazards during the use of the equipment. Therefore, when choosing a homogenizer, they must provide quality and safety documents.
7、 After sales service: When the high-pressure homogenizer equipment is in a high-pressure working state for a long time, it is inevitable that some faults and wear will occur. When users choose the high-pressure homogenizer, after-sales service should be evaluated as a crucial indicator.
