Establishing core technical standards and quality control platform for scientific research reagents in China

At present, the National Science and Technology Support Program project "Development and Engineering Research of Standard Specifications for Organic Reagents for Scientific Research" undertaken by the China Institute of Metrology has passed the project acceptance organized by the Research Conditions and Finance Department of the Ministry of Science and Technology and the achievement appraisal organized by the General Administration of Quality Supervision, Inspection and Quarantine. The appraisal opinion believes that some of the research results of this project have reached an advanced level, and there are gaps in related technologies such as reagent standardization and quality control in the domestic field. This is of great significance for improving the production and quality control of scientific research reagents in China.
Scientific research reagents are essential and key material foundations in scientific research, with widespread demand in key fields such as life sciences, new drug development, new materials, new energy, food, and environment. They are an important support and guarantee for the development of technological innovation. There are many types of reagents used in scientific research, with wide applications, high quality requirements, fast updates, and high difficulty in engineering and standardization. There is a significant gap between the overall level of scientific research reagents in China and the * level, and the core basic organic research reagents still heavily rely on imports.

To this end, the China Institute of Metrology undertook the key project of the National Science and Technology Support Program in 2010, "Development and Engineering Research of Standards and Specifications for Organic Reagents for Scientific Research", and jointly conducted research on the development and engineering of standards and specifications for basic and core reagents for scientific research with four units including Tianjin Concord Technology Co., Ltd., Tianjin Bonaijer Technology Co., Ltd., China Academy of Atomic Energy Sciences, and Beijing University of Chemical Technology.

On the basis of the achievements of the "Eleventh Five Year Plan" National Science and Technology Support Program project "Research and Development of Core Unit Substances and Common Key Technologies for High Purity Organic Reagents for Scientific Research", this project aims to carry out research on the quality and standard specifications of high-purity organic reagents in China, improve the quality of high-purity organic reagent products, and conduct in-depth research on key technologies for the preparation of high-purity organic reagents, as well as research on the engineering of organic reagents and the quality control evaluation system for special packaging, storage and transportation processes.

According to researcher Li Hongmei, director of the Institute of Chemistry at the Chinese Academy of Metrology, through technological breakthroughs and innovative mechanisms and models, the research team has focused on solving the formulation and engineering research of standards and specifications for organic reagents used in scientific research. They have established eight high-purity organic reagent analysis method systems, including pesticide residue grade acetonitrile, spectral grade acetonitrile, mass spectral grade acetonitrile, pesticide residue grade ethyl acetate, pesticide residue grade ethanol, spectral grade ethanol, chromatographic grade n-hexane, and pesticide residue grade n-hexane; We have established one set of packaging materials, storage and transportation quality control, and evaluation systems for organic reagents and inorganic isotope reagents; Established one set of quality control and evaluation system for organic isotope reagents; A benign mechanism model combining industry, academia, research, and application of high-purity organic reagents for scientific research has been established.

The research group also innovatively established key preparation technologies such as "ultra-fine real-time online distillation control, removal of ultra trace target impurities in pesticide residue grade solvents", and applied for 25 standards including 5 national standards, laying a good foundation for quality control, technology transformation, and promotion in the productization process of 31 high-purity organic reagents for scientific research.

The research results of the project have high application value. The core technology standards and quality control platform for scientific research reagents established have broken the long-term dependence on imported high-purity organic reagents in China, reduced the dependence on foreign technology, and played an important role in improving the quality and market competitiveness of high-purity reagents in China.