toc analyzerApplication Cases
TOC analyzer monitoring reduces production downtime risk
Hanmi is a pharmaceutical company in South Korea, and its offline Total Organic Carbon (TOC) analyzer cannot always effectively diagnose in injection water storage tanks with high TOC. After installing the electrode of the TOC analyzer, the company was able to quickly identify the root cause of the problem and successfully avoid the occurrence of a huge production shutdown event.
TOC analysis in pharmaceutical grade water is used to detect organic pollutants. When the TOC content exceeds the standard, the production line must be stopped and the water system must be comprehensively tested; The shutdown inspection process may require a shutdown of up to a week. Therefore, real-time measurement of TOC can detect an increase in TOC in a timely manner, which may indicate that the pure water system is about to malfunction.
Offline monitoring is sometimes powerless
Hanmi Pharmaceutical Co. Ltd. was founded in 1973 and has now become the second largest pharmaceutical company in South Korea, with total sales of $550 million. After installing a new injection water (WFI) storage tank in one of Hanmi's main production plants, offline testing showed that TOC exceeded the standard. The measurement results of an analyzer manufactured by another manufacturer indicate intermittent exceedance of TOC readings during the sampling process. However, the batch sampling analysis system has long measurement intervals and inconsistent results, making it difficult to determine the cause of TOC increase.
Real time TOC measurement helps identify vulnerabilities
Hanmi installed a TOC. Real time indication of TOC differences in the water system can lead to the conclusion that TOC is directly related to the system water level. Upon further investigation, it was discovered that a pinhole had appeared above the insulation layer of the injection water storage tank. This causes unprocessed water to leak into the pure water circuit when the water level in the insulation layer approaches the water level. After repairing the leakage issue, the TOC measurement value returned to the specified value.
After discovering this pinhole on the insulation layer of the storage tank through continuous online monitoring of TOC, Hanmi Pharmaceutical successfully solved the problem and avoided the consequences of huge losses and time-consuming shutdowns. The customer is satisfied with the high precision, reliability, process stability, and low maintenance workload of the online process monitoring instrument. In the following year, the company plans to build a new production plant and install three systems including TOC analyzers.
