The microfluidic control preparation instrument is based on the theory of microfluidic mechanics, which precisely controls fluids through micro to nano level channels to achieve functions such as sample preparation, mixing, emulsification, and separation and purification. The core principle can be decomposed into the following steps:

Fluid Drive and Control

Power source: Using high-precision injection pumps or high-pressure delivery pumps, the flow rate and pressure are precisely controlled through preset programs to ensure stable fluid delivery.

Micro valve system: integrating active and passive valves to achieve fluid switching, regulation, and switching, such as precise control of the mixing ratio of lipids and nucleic acids in mRNA LNP preparation.

Microfluidic chip design

Chip structure: made of glass, silicon, or polymer, with a minimum channel size of up to 20 μ m, and a complex channel network etched through photolithography or microfabrication techniques.

Channel function: Design turbulent, laminar, or atomization areas, such as in liposome preparation, by controlling the emulsification process through channel curvature, to achieve a minimum particle size of up to 100nm and a PDI below 0.1.

Multi parameter collaborative regulation

Temperature control: Integrated heating module, capable of heating up to 100 ℃, suitable for mRNA encapsulation or liposome incubation.

Sensor feedback: Equipped with temperature, pressure, and optical sensors, real-time monitoring of experimental status and parameter adjustment to ensure reproducibility error ≤ 1%.

2、 Unique advantages:

The performance is comparable to imported products, and the price is less than one-fifth of imported products.

The dead volume is small, less than 0.05ml, with no official connection in the middle. The part in contact with the liquid is a disposable syringe and 316L stainless steel chip, which can be steam sterilized.

316L stainless steel chips have no limit on usage times, no consumable costs, and can withstand organic solvents such as chloroform.

The chip interface has a withstand voltage of 0.7Mpa, ensuring no material leakage during use.

It has a heating function, which can be used for mRNA LNP encapsulation or liposome encapsulation, and can be heated above the phospholipid phase transition temperature.

The device has a small size and can be operated in a biosafety cabinet to avoid contamination.