Sugar alcohols are substances in which the aldehyde or ketone groups of sugars are reduced. Generally, it is a special sweetener formed by hydrogenation of corresponding sugars catalyzed by nickel. It has the characteristics of lower sweetness than sucrose, lower calorific value, and can improve food organization and taste. Sugar alcohols are widely used to make sugar substitutes for diabetics and develop into sugar free food industry because they have the advantages of preventing caries, lowering cholesterol, preventing diabetes, losing weight, and low energy. At present, widely used sugar alcohol substances include erythritol, maltitol, sorbitol, xylitol, etc. The content of various sugar alcohols in food has certain standards, so the detection of sugar alcohols in food has important practical significance. There are currently various methods for detecting sugar alcohols, such asHPLC-RIandHPLC-ELSDWait. among themHPLC-ELSDThe method has many advantages such as stable baseline, good separation effect, accurate results, and simple sample pretreatment. Shanghai Tongwei Analysis Technology Co., Ltd. adopts a method to address the difficulty in separating and detecting sorbitol and isosorbideHPLC-ELSDThe separation and detection of sorbitol and isosorbide have been achieved, which can meet the requirements of daily analysis.