Thermal field flow separatorIt is an open channel separation and analysis technology based on temperature gradient and thermal diffusion. It has no fixed phase and can separate macromolecules, colloids and particles according to size/hydrodynamic volume and thermal diffusion coefficient (chemical property). It is commonly used for characterization of polymers, blends, gel and related particles. It can be combined with MALS, RI, UV and other detectors to obtain absolute molecular weight, particle size and component content.
Core principles and processes:
The channel is a flat open flow channel, with a temperature gradient formed on the upper and lower walls. Thermal diffusion causes components to drift towards the accumulation surface, while Brownian diffusion causes them to move away, achieving dynamic equilibrium.
The flow velocity in the channel follows a parabolic distribution, and the component flow velocity near the accumulation surface is slow and peaks late; The components far away from the accumulation surface have fast flow rate and early peak, achieving graded outflow.
Adjusting temperature difference, flow rate, and carrier liquid can optimize separation and adapt to different sample systems and target components.
Advantages: No fixed phase, reducing adsorption and shear; Balancing the separation of size and chemical properties; Can be used in conjunction with multiple detectors to obtain multidimensional data.
Thermal field flow separatorTechnical features:
Low shear force: protects the integrity of the separated sample and avoids damage to the sample during the separation process.
The separation channel design has improved resolution and accelerated separation time.
Fully automated system: using professional software system for overall control, it can connect various additional analysis modules and components, such as automatic sampler, deaerator, pump, etc.
Multiple detectors can be connected, such as dynamic and static laser light scattering instruments, to provide more comprehensive sample information.