Surface enhanced Raman substrate SERStrate - ultra sensitive molecular detection

Super sensitive! Haoliang Optoelectronic SERS Substrate makes trace molecule detection simpler and more efficient

In the field of trace molecule detection, traditional SERS substrates face multiple challenges: complex photolithography processes drive up manufacturing costs, poor signal uniformity makes quantitative analysis difficult, and insufficient sensitivity makes it difficult to captureUltra low concentration moleculesAnd the stability is worrying in harsh environments. Haoliang Optoelectronics has newly launchedSERStrate SERS substrateBy using revolutionary reactive ion etching technology to break through bottlenecks and achieve a leap from "trace detection" to "precise analysis", customized solutions are provided for fields such as life sciences, food safety, and environmental monitoring.

1、 Technical principles

The SERStrate substrate adopts a gold/silver nanowire array structure, and its technical principle is that when the incident laser excites, the free electrons on the metal surface produce collective oscillations, forming a strong local electromagnetic field "hotspot". This electromagnetic field enhancement effect increases the Raman signal of molecules adsorbed on the surface of nanostructures by 10%⁶-10 ¹⁴ times, achieving single molecule level detection sensitivity.

SERStrate substrate is different from traditional polymer mask lithography technology, with high preparation difficulty and long time. This substrate can be prepared through only two simple processes: first, constructing ordered micro nano structures on a nano silicon substrate, and then forming a uniform gold/silver coating through vapor deposition. The reactive ion etching process avoids complex chemical treatments, significantly reduces production costs, and ensures structural consistency, enabling large-scale production.

2、 Product Highlights

1. The Raman enhancement rate of gold/silver SERStrate is higher than any other gold/silver SERS substrate on the market today

The Raman enhancement rate of gold/silver SERStrate is higher than any other gold/silver SERS substrate on the market today. The experimental results show that the Raman enhancement factor is as high as 1011, and the signal amplification effect is outstanding, making trace molecule detection easier.

2. Accurately adapt to lasers without the need for parameter tuning

Our SERS substrates are divided into gold and silver films, designed specifically for 532-785nm laser excitation, covering mainstream wavelengths such as 785nm, directly matching commonly used Raman equipment in the laboratory, saving the trouble of parameter tuning.

3. Uniform Raman enhancement on the entire substrate

The Raman enhancement effect of SERS substrate covers the entire substrate, and there is no problem of uneven local signal strength. No matter which area of the substrate is detected, stable signals can be obtained.

4. Repeatable enhancement between different substrates and batches, enabling quantitative analysis

The enhancement effect of SERS substrate remains consistent among different substrates and production batches, and the data can be repeatedly verified, directly solving the pain point of "large batch differences" in traditional substrates and easily achieving quantitative analysis.

Figure 4: SEM image of SERS substrate, with highly consistent nanostructures and uniform density

5. Low background signal

The SERS substrate has ultra-low self fluorescence and impurity signals, with clear and sharp characteristic peaks of target molecules, reducing signal interference and eliminating the need for repeated data screening, resulting in more efficient and accurate analysis.

6. Can be used for corrosive solvents and high temperatures

SERS substrates can be directly used in corrosive solvents and can withstand high temperature environments without additional protective treatment, making them suitable for more complex detection scenarios and highly practical.

3、 SERStrate substrate technical parameters

4、 Application Fields

• Food safetySERSThe substrate can accurately detect melamine in dairy products and quickly screen grainsHuangqumycin DuFruit and vegetable pesticides, truly integratedFull chain monitoring from farmland to dining table.

• Environmental monitoring:Toxic substances such as polychlorinated biphenyls (PCBs) and HCN in water bodies, adsorbed heavy metal ions in soil, and volatile organic compounds (VOCs) in the atmosphere can all be accurately captured or analyzed using SERStrate substrates.

  
  

• biomedical science:The SERStrate substrate can not only monitor real-time pH changes in living cells, but also ultra sensitively detect cancer markers such as ctDNA and extracellular vesicle proteins, while tracking drug metabolism molecules, helping with precision medicine and early disease diagnosis.

  
  

• Public safety:SERStrate substrates can be used for explosive DNTT NTTrace detection, rapid identification of chemical agents, and screening of dangerous goods at airports and customs can all be achieved through it, providing portable high-precision tools for national defense security and public emergency response.

Haoliang Optoelectronics SERStrate SERS substrate, with the core advantages of Raman enhancement rate, ppb level ultra sensitive detection, uniform response across the substrate, and stable repeatability across batches, combined with corrosion-resistant solvents and strong adaptability to high temperatures, solves the performance pain points of traditional substrates. Whether it is precise quantitative requirements in scientific research experiments or efficient detection scenarios in industrial implementation, we can match customer needs. In addition, weImplement inventory based shipping with no minimum order quantitySave your waiting time and costs, the more you purchase, the greater the discount! Welcome to consult anytime for exclusive customized solutions that can easily achieve precise capture of trace molecules, making detection work more efficient and reliable!

Regarding Haoliang Optoelectronics:

Shanghai Haoliang Optoelectronic Equipment Co., Ltd. is a professional agent for optoelectronic products, including various types of lasers, optoelectronic modulators, optical measurement equipment, optical components, etc., covering applications such as material processing, optical communication, biomedicine, scientific research, national defense, quantum optics, biological microscopy, IoT sensing, laser manufacturing, etc; We can provide customers with complete equipment installation, training, hardware development, software development, system integration and other services.